Results 41 to 50 of about 438,052 (300)

Combined TGF-β3 and FGF-2 Stimulation Enhances Chondrogenic Potential of Ovine Bone Marrow-Derived MSCs

Cells
Mesenchymal stem cells (MSCs) represent a promising cell source for cartilage tissue engineering due to their chondrogenic potential. However, current differentiation protocols result in limited efficiency.
Sandra Stamnitz, Agnieszka Krawczenko, Aleksandra Klimczak   +2 more
doaj   +1 more source

The miR-139-5p regulates proliferation of supratentorial paediatric low-grade gliomas by targeting the PI3K/AKT/mTORC1 signalling [PDF]

, 2018
Paediatric low-grade gliomas (pLGGs) are a heterogeneous group of brain tumours associated with a high overall survival: however, they are prone to recur and supratentorial lesions are difficult to resect, being associated with high percentage of disease
Antonelli, Manila, Badiali, Manuela, Besharat, Zein Mersini, Capper, David, Carai, Andrea, Catanzaro, Giuseppina, Chiacchiarini, Martina, Ferretti, Elisabetta, Giangaspero, Felice, Locatelli, Franco, Marras, Carlo Efisio, Mascelli, Samantha, Mastronuzzi, Angela, Miele, Evelina, Po, Agnese, Raso, Alessandro, Schrimpf, Daniel, Stichel, Damian, Tartaglia, Marco, von Deimling, Andreas   +19 more
core   +1 more source

Mesenchymal stem cell infiltration during neoplastic transformation of the human prostate [PDF]

Oncotarget, 2017
Mesenchymal Stem Cells (MSCs) have been identified in prostate cancer, raising the critical question of their physical and temporal source. Therefore, MSCs were quantified and characterized in benign and malignant prostate tissue representing different disease states and a wide range of age groups from fetal development through adult death using ...
Brennen, W Nathaniel, Zhang, Baohui, Kulac, Ibrahim, Kisteman, L Nelleke, Antony, Lizamma, Wang, Hao, Meeker, Alan K, De Marzo, Angelo M, Garraway, Isla P, Denmeade, Samuel R, Isaacs, John T   +10 more
openaire   +4 more sources

A Murine Model With JAK2V617F Expression in Both Hematopoietic Cells and Vascular Endothelial Cells Recapitulates the Key Features of Human Myeloproliferative Neoplasm

Frontiers in Oncology, 2021
The myeloproliferative neoplasms (MPNs) are characterized by an expansion of the neoplastic hematopoietic stem/progenitor cells (HSPC) and an increased risk of cardiovascular complications.
Haotian Zhang, Amar Yeware, Sandy Lee, Huichun Zhan, Huichun Zhan   +4 more
doaj   +1 more source

Posttransplant lymphoproliferative disorders in neuronal xenotransplanted macaques [PDF]

, 2016
Posttransplant lymphoproliferative disorders (PTLDs) are a heterogeneous group of lymphoid proliferations that occur in the setting of depressed T-cell function due to immunosuppressive therapy used following solid organ transplantation, hematopoietic ...
Aron Badin, R., Cavicchioli, L., Cozzi, E., Crossan, C., Danesi, A., Ferraresso, S., Hantraye, P., Kaliyaperumal, S., Knight, H., Scobie, L., Trez, D., Vadori, M., Westmoreland, S.   +12 more
core   +1 more source

Cytoplasmic expression of LGR5 in pancreatic adenocarcinoma.

Frontiers in Physiology, 2013
Background: CD133 has been identified as a cancer stem cell (CSC) marker for pancreatic ductal adenocarcinoma. Although leucine-rich-repeat-containing G-protein-coupled receptor 5 (LGR5), a marker of intestinal stem cells, has been shown to be on a ...
Nobumasa eMizuno, Yasushi eYatabe, Kazuo eHara, Susumu eHijioka, Hiroshi eImaoka, Yasuhiro eShimizu, Shigeru B.H. Ko, Kenji eYamao   +7 more
doaj   +1 more source

Drosophila as a model system to study nonautonomous mechanisms affecting tumour growth and cell death [PDF]

, 2018
The study of cancer has represented a central focus in medical research for over a century. The great complexity and constant evolution of the pathology require the use of multiple research model systems and interdisciplinary approaches.
Cordero, Julia B., Hodgson, Joseph A., Parvy, Jean-Philippe   +2 more
core   +3 more sources

Aneuploid embryonic stem cells exhibit impaired differentiation and increased neoplastic potential [PDF]

The EMBO Journal, 2016
Aneuploidy leads to severe developmental defects in mammals and is also a hallmark of cancer. However, whether aneuploidy is a driving cause or a consequence of tumor formation remains controversial. Paradoxically, existing studies based on aneuploid yeast and mouse fibroblasts have shown that aneuploidy is usually detrimental to cellular fitness. Here,
Meili Zhang, Li Cheng, Yuyan Jia, Guang Liu, Cuiping Li, Shuhui Song, Allan Bradley, Yue Huang   +7 more
openaire   +2 more sources

Complexity of the Genetic Background of Oncogenesis in Ovarian Cancer—Genetic Instability and Clinical Implications

Cells
Ovarian cancer is a leading cause of death among women with gynecological cancers, and is often diagnosed at advanced stages, leading to poor outcomes.
Marek Murawski, Adam Jagodziński, Aleksandra Bielawska-Pohl, Aleksandra Klimczak   +3 more
doaj   +1 more source

Stromal CD10 expression in breast cancer correlates with tumor invasion and cancer stem cell phenotype

BMC Cancer, 2018
Background Previous investigations have indicated that CD10 is associated with biological aggressivity in human cancers, but the use of this marker for diagnosis and prognosis is more complex.
Tahani Louhichi, Hanene Saad, Myriam Ben Dhiab, Sonia Ziadi, Mounir Trimeche   +4 more
doaj   +1 more source