Results 41 to 50 of about 387,984 (293)

Immunorecognition of leukemic stem cells by NK cells : the role of HDAC inhibitors in NKG2D ligand-mediated anti-tumor responses in acute myeloid leukemia [PDF]

, 2008
The diagnosis of acute myeloid leukemia (AML) is associated to a poor long-term outcome due to frequent relapse despite intensive chemotherapy, radiation and hematopoietic stem cell transplantation (HSCT) as well as continuous advances in treatment ...
Langenkamp, Ulrich
core   +1 more source

Complexity of the Genetic Background of Oncogenesis in Ovarian Cancer—Genetic Instability and Clinical Implications

Cells
Ovarian cancer is a leading cause of death among women with gynecological cancers, and is often diagnosed at advanced stages, leading to poor outcomes.
Marek Murawski, Adam Jagodziński, Aleksandra Bielawska-Pohl, Aleksandra Klimczak   +3 more
doaj   +1 more source

Stromal CD10 expression in breast cancer correlates with tumor invasion and cancer stem cell phenotype

BMC Cancer, 2018
Background Previous investigations have indicated that CD10 is associated with biological aggressivity in human cancers, but the use of this marker for diagnosis and prognosis is more complex.
Tahani Louhichi, Hanene Saad, Myriam Ben Dhiab, Sonia Ziadi, Mounir Trimeche   +4 more
doaj   +1 more source

Absence of a dose-rate effect in the transformation of C3H 10T1/2 cells by α-particles [PDF]

, 1987
The findings of Hill et al. (1984) on the greatly enhanced transformation frequencies at very low dose rates of fission neutrons induced us to perform an analogous study with -particles at comparable dose rates. Transformation frequencies were determined
Fenn, S., Fromke, E., Kellerer, Albrecht M., Hieber, L., Ponsel, G., Roos, H.   +5 more
core   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Transformed bone marrow cells generate neoplasms of distinct histogenesis. a murine model of cancer transplantation

Stem Cell Research, 2019
The last several years have witnessed renewed interest regarding the contribution of cancer stem cells in tumorigenesis and neoplastic heterogeneity. It has been reported that patients who undergo bone marrow transplantation are more prone to develop a ...
Mireia Castillo-Martin, Nataliya Gladoun, Dan Han, Adolfo Firpo-Betancourt, Jose M. Silva, Carlos Cordon-Cardo   +5 more
doaj   +1 more source

Human Cancer Cells Express Slug-based Epithelial-Mesenchymal Transition Gene Signature Obtained in Vivo

, 2011
The biological mechanisms underlying cancer cell motility and invasiveness remain unclear, although it has been hypothesized that they involve some type of epithelial-mesenchymal transition (EMT).
Rumjantseva Viktoria, Cheng Weiyi, Viktoria Rumjantseva, Kandel Jessica J, Jessica J Kandel, Yamashiro, Darrell, Jianzhong Huang, Peter D. Canoll, Huang, Jianzhong, Dimitris Anastassiou, Anastassiou Dimitris, Darrell J Yamashiro, Yamashiro Darrell J, Canoll Peter D, Canoll, Peter D., Kandel, Jessica J., Wei-yi Cheng, Rumjantseva, Viktoria, Huang Jianzhong, Jessica J. Kandel, Cheng, Weiyi, Darrell J. Yamashiro, Weiyi Cheng, Anastassiou, Dimitris, Peter D Canoll   +24 more
core   +1 more source

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source

A GBM-like V-ATPase signature directs cell-cell tumor signaling and reprogramming via large oncosomesResearch in context

EBioMedicine, 2019
Background: The V-ATPase proton pump controls acidification of intra and extra-cellular milieu in both physiological and pathological conditions. We previously showed that some V-ATPase subunits are enriched in glioma stem cells and in patients with poor
Irene Bertolini, Andrea Terrasi, Cristina Martelli, Gabriella Gaudioso, Andrea Di Cristofori, Alessandra Maria Storaci, Miriam Formica, Paola Braidotti, Katia Todoerti, Stefano Ferrero, Manuela Caroli, Luisa Ottobrini, Thomas Vaccari, Valentina Vaira   +13 more
doaj   +1 more source

Paracrine signaling in stem cell renewal and in neoplastic tumor growth [PDF]

Science China Life Sciences, 2014
Paracrine pathway activities are being increasingly recognized as instrumental regulatory mechanisms of epithelial-stromal interactions that play important roles in physiological and pathological self-renewal of stem cells and in the initiation and maintenance of neoplastic tumor development.
openaire   +2 more sources