Results 61 to 70 of about 387,984 (293)

c‐Rel–dependent Chk2 signaling regulates the DNA damage response limiting hepatocarcinogenesis

Hepatology, EarlyView., 2022
In response to genotoxic injury, c‐Rel upregulates ATM‐Chk2‐p53 pathway DNA damage proteins to limiting hepatocarcinogenesis. Abstract Background and Aims Hepatocellular carcinoma (HCC) is a leading cause of cancer‐related death. The NF‐κB transcription factor family subunit c‐Rel is typically protumorigenic; however, it has recently been reported as a
Jack Leslie, Jill E. Hunter, Amy Collins, Amelia Rushton, Lauren G. Russell, Erik Ramon‐Gil, Maja Laszczewska, Misti McCain, Marco Y. W. Zaki, Amber Knox, Yixin Seow, Laura Sabater, Daniel Geh, Neil D. Perkins, Helen L. Reeves, Dina Tiniakos, Derek A. Mann, Fiona Oakley   +17 more
wiley   +1 more source

Isolation, cultivation and characterization of CD133+ stem cells from human glioblastoma [PDF]

Einstein (São Paulo), 2012
Objective: To establish the method of isolation and culture ofhuman glioblastoma neurospheres, and the purification of theirstem cells, followed by the process of obtaining tumor subspheres,immunophenotypically characterizing this clonogenic set. Methods:
Lorena Favaro Pavon, Luciana Cavalheiro Marti, Tatiana Tais Sibov, Liza Aya Mabuchi Miyaki, Suzana Maria Fleury Malheiros, Javier Bustamante Mamani, Reynaldo Andre Brandt, Guilherme Carvalhal Ribas, Jorge Roberto Pagura, Marcos Augusto Stavale Joaquim, Hallin Feres Junior, Lionel Fernel Gamarra   +11 more
doaj   +2 more sources

Gliomatosis Cerebri in a Dog

Brazilian Journal of Veterinary Pathology, 2011
A 6-year-old, female, mixed-breed dog was presented for necropsy with history of prostration and incoordination followed by circling to the right and seizures. There were no gross findings in the brain.
Fabiano J. F. de Sant’Ana, Claudio S. L. Barros   +1 more
doaj   +1 more source

Mesenchymal stem cells as all-round supporters in a normal and neoplastic microenvironment [PDF]

Cell Communication and Signaling, 2012
Mesenchymal stem cells (MSC) represent a heterogeneous population exhibiting stem cell-like properties which are distributed almost ubiquitously among perivascular niches of various human tissues and organs. Organismal requirements such as tissue damage determine interdisciplinary functions of resident MSC including self-renewal, migration and ...
Hass Ralf, Otte Anna
openaire   +3 more sources

Regulation of the self-renewal vs. differentiation decision in the C.elegans germline [PDF]

, 2011
Adult stem cells are the basis of our reproductive potential, of tissue growth and maintenance, and of wound healing and regeneration. Ageing phenotypes such as hair loss or brittle bones in fact reflect the gradual decline of the proliferative ...
Kalchhauser, Irene
core   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

TP53 R249S mutation in hepatic organoids captures the predisposing cancer risk

Hepatology, EarlyView., 2022
The systematic approach in elucidating the gain‐of‐function (GOF) roles of TP53 mutations in early liver carcinogenesis. Unique downstream targets of TP53 L3 mutations were identified from chormatin immunoprecipitation sequencing in HCC cell lines, followed by a series of validation assays to substantiate the exclusive transcriptional regulations ...
Yin Kau Lam, Jianqing Yu, Hao Huang, Xiaofan Ding, Alissa M. Wong, Howard H. Leung, Anthony W. Chan, Kelvin K. Ng, Mingjing Xu, Xin Wang, Nathalie Wong   +10 more
wiley   +1 more source

Prospective Isolation and Comparison of Human Germinal Matrix and Glioblastoma EGFR+ Populations with Stem Cell Properties

Stem Cell Reports, 2017
Characterization of non-neoplastic and malignant human stem cell populations in their native state can provide new insights into gliomagenesis. Here we developed a purification strategy to directly isolate EGFR+/− populations from human germinal matrix ...
Jessica Tome-Garcia, Rut Tejero, German Nudelman, Raymund L. Yong, Robert Sebra, Huaien Wang, Mary Fowkes, Margret Magid, Martin Walsh, Violeta Silva-Vargas, Elena Zaslavsky, Roland H. Friedel, Fiona Doetsch, Nadejda M. Tsankova   +13 more
doaj   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

Defining properties of neural crest-derived progenitor cells from the apex of human developing tooth [PDF]

, 2008
The connective tissue of the human tooth arises from cells that are derived from the cranial neural crest and, thus, are termed as "ectomesenchymal cells." Here, cells being located in a pad-like tissue adjacent to the apex of the developing tooth, which
Götz, Werner, Schönebeck, Bodo, Degistirici, Ozer, Siemonsmeier, Jürgen, Martin, Ivan, Jaquiery, Claude, Thie, Michael   +6 more
core