Results 21 to 30 of about 438,052 (300)

Association between CD133 expression and clinicopathological profile in colorectal cancer [PDF]

Medicinski Glasnik, 2020
Aim To investigate CD133 expression and its relationship to clinicopathological profile in colorectal cancer (CRC) patients. Methods This cross-sectional study was performed at the Internal Medicine Department, School of Medicine, Adam Malik General ...
Imelda Rey, Agung Putra, Dharma Lindarto, Fauzi Yusuf   +3 more
doaj   +1 more source

Whole tumor RNA-sequencing and deconvolution reveal a clinically-prognostic PTEN/PI3K-regulated glioma transcriptional signature [PDF]

, 2017
The concept that solid tumors are maintained by a productive interplay between neoplastic and non-neoplastic elements has gained traction with the demonstration that stromal fibroblasts and immune system cells dictate cancer development and progression ...
Bush, Erin C, Gutmann, David H, Ma, Yu, Pan, Yuan, Sims, Peter A, Solga, Anne C, Toonen, Joseph A   +6 more
core   +2 more sources

A systematic approach to cancer: evolution beyond selection. [PDF]

, 2017
Cancer is typically scrutinized as a pathological process characterized by chromosomal aberrations and clonal expansion subject to stochastic Darwinian selection within adaptive cellular ecosystems.
Miller, William B, Torday, John S
core   +1 more source

Heterogeneity of Neoplastic Stem Cells: Theoretical, Functional, and Clinical Implications [PDF]

Cancer Research, 2013
Abstract Accumulating evidence suggests that human cancers develop through a step-wise, but nonlinear process of cellular diversification and evolution. Recent mutational analyses indicate that this process is more complex and diverse than anticipated before whole-genome sequencing methods were readily available.
Peter, Valent, Dominique, Bonnet, Stefan, Wöhrer, Michael, Andreeff, Mhairi, Copland, Christine, Chomienne, Connie, Eaves   +6 more
openaire   +2 more sources

Mesenchymal Stem Cell-Derived Antimicrobial Peptides as Potential Anti-Neoplastic Agents: New Insight into Anticancer Mechanisms of Stem Cells and Exosomes

Frontiers in Cell and Developmental Biology, 2022
Mesenchymal stem cells (MSCs), as adult multipotent cells, possess considerable regenerative and anti-neoplastic effects, from inducing apoptosis in the cancer cells to reducing multidrug resistance that bring them up as an appropriate alternative for ...
Kasra Moeinabadi-Bidgoli, Kasra Moeinabadi-Bidgoli, Malihe Rezaee, Malihe Rezaee, Hamidreza Rismanchi, Mohaddese Malek Mohammadi, Amirhesam Babajani   +6 more
doaj   +1 more source

Cellular interactions in the tumor microenvironment: the role of secretome [PDF]

, 2019
Over the past years, it has become evident that cancer initiation and progression depends on several components of the tumor microenvironment, including inflammatory and immune cells, fibroblasts, endothelial cells, adipocytes, and extracellular matrix ...
Castelo-Branco, Pedro, da Cunha, Bianca Rodrigues, Domingos, Célia, Henrique, Tiago, Polachini, Giovana Mussi, Stefanini, Ana Carolina Buzzo, Tajara, Eloiza Helena   +6 more
core   +1 more source

Neoplastic stem cells: A novel therapeutic target in clinical oncology [PDF]

Cancer, 2006
AbstractCancer is among the leading causes of morbidity and mortality in the Western world. Despite recent advances, most therapeutic approaches fail to eradicate the entire neoplastic clone. The remaining cells often develop metastasis and/or recurrences and therefore may represent attractive targets of therapy.
Axel, Schulenburg, Herbert, Ulrich-Pur, Dietmar, Thurnher, Boban, Erovic, Stefan, Florian, Wolfgang R, Sperr, Peter, Kalhs, Brigitte, Marian, Friedrich, Wrba, Christoph C, Zielinski, Peter, Valent   +10 more
openaire   +2 more sources

YB-1 dependent oncolytic adenovirus efficiently inhibits tumor growth of glioma cancer stem like cells [PDF]

, 2013
Background: The brain cancer stem cell (CSC) model describes a small subset of glioma cells as being responsible for tumor initiation, conferring therapy resistance and tumor recurrence.
Beier, Dagmar, Girbinger, Vroni, Holm, Per Sonne, Lage, Hermann, Mantwill, Klaus, Mittelbronn, Michel Guy André, Naumann, Ulrike, Schlegel, Jürgen, Seznec, Janina, Surowiak, Pawel   +9 more
core   +1 more source

Natural Killer Cells: Diverse Functions in Tumor Immunity and Defects in Pre-neoplastic and Neoplastic Stages of Tumorigenesis

Molecular Therapy: Oncolytics, 2020
Natural killer (NK) cells are the key immune effectors with the ability to mediate selection and differentiation of a number of different cancer stem cells/undifferentiated tumors via lysis, and secreted or membrane-bound interferon (IFN)-γ and tumor ...
Anahid Jewett, Janko Kos, Kawaljit Kaur, Tahmineh Safaei, Christine Sutanto, Wuyang Chen, Paul Wong, Artin Keshishian Namagerdi, Changge Fang, Yuman Fong, Meng-Wei Ko   +10 more
doaj   +1 more source

Common features between neoplastic and preneoplastic lesions of the biliary tract and the pancreas [PDF]

, 2019
The bile duct system and pancreas show many similarities due to their anatomical proximity and common embryological origin. Consequently, preneoplastic and neoplastic lesions of the bile duct and pancreas share analogies in terms of molecular ...
Alvaro, D, Arcidiacono, Pg, Capurso, G., Cardinale, V, Carpino, G, Doglioni, C, Gaudio, E, Pedica, F, Petrone, Mc, Severi, C, Zaccari, P   +10 more
core   +1 more source