Results 21 to 30 of about 387,984 (293)
Mist1 Expressing Gastric Stem Cells Maintain the Normal and Neoplastic Gastric Epithelium and Are Supported by a Perivascular Stem Cell Niche [PDF]
Cancer Cell, 2015 The regulation and stem cell origin of normal and neoplastic gastric glands are uncertain. Here, we show that Mist1 expression marks quiescent stem cells in the gastric corpus isthmus. Mist1(+) stem cells serve as a cell-of-origin for intestinal-type cancer with the combination of Kras and Apc mutation and for diffuse-type cancer with the loss of E ...
Yoku Hayakawa +2 more
exaly +6 more sources
Cell surface GRP78 promotes stemness in normal and neoplastic cells [PDF]
Scientific Reports, 2020 Abstract Reliable approaches to identify stem cell mechanisms that mediate aggressive cancer could have great therapeutic value, based on the growing evidence of embryonic signatures in metastatic cancers. However, how to best identify and target stem-like mechanisms aberrantly acquired by cancer cells has been ...
Clay Conner +13 more
openaire +3 more sources
Cells, 2021 Mesenchymal stem cell-based therapies are promising tools for bone tissue regeneration. However, tracking cells and maintaining them in the site of injury is difficult. A potential solution is to seed the cells onto a biocompatible scaffold.
Sandra Stamnitz, Aleksandra Klimczak
doaj +1 more source
Cancer Stem Cells : Significance in Origin, Pathogenesis and Treatment of Glioblastoma [PDF]
, 2021 Publisher Copyright: © 2021 by the authors. Licensee MDPI, Basel, Switzerland.Cancer stem cells (CSCs), known also as tumor-initiating cells, are quiescent, pluripotent, self-renewing neoplastic cells that were first identified in hematologic tumors and ...
Strumfa, Ilze +7 more
core +1 more source
Cells, 2022 Mesenchymal stem cells (MSCs) attract interest in regenerative medicine for their potential application in bone regeneration. However, direct transplantation of cells into damaged tissue is not efficient enough to regenerate large bone defects.
Sandra Stamnitz +8 more
doaj +1 more source
Thrombopoietin in normal and neoplastic stem cell development [PDF]
Best Practice & Research Clinical Haematology, 2009 It has been known for sometime that thrombopoietin acts on megakaryocytic progenitor cells to stimulate platelet production. It has recently been discovered that it also stimulates the self-renewal and expansion of normal murine and human haematopoietic stem cells (HSCs) by acting on its cognate receptor, the product of the myeloproliferative leukaemia
Kenneth, Kaushansky, Helen M, Ranney
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Leukemic stem cell frequency: a strong biomarker for clinical outcome in acute myeloid leukemia. [PDF]
PLoS ONE, 2014 INTRODUCTION: Treatment failure in acute myeloid leukemia is probably caused by the presence of leukemia initiating cells, also referred to as leukemic stem cells, at diagnosis and their persistence after therapy. Specific identification of leukemia stem
Monique Terwijn +11 more
doaj +1 more source
STEM CELL IN GASTROINTESTINAL STRUCTURE AND NEOPLASTIC DEVELOPMENT [PDF]
Gut, 2004 Stem cells are primitive cells located in a specialised mesenchymal “niche” that lack expression of any definitive markers of lineage commitment and are therefore difficult to define and identify. Stem cells maintain their capacity for limitless self replication throughout the lifetime of their host, and can also divide to produce daughter cells ...
M, Brittan, N A, Wright
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Cells, 2020 Duchenne muscular dystrophy (DMD) is a genetic disorder associated with a progressive deficiency of dystrophin that leads to skeletal muscle degeneration.
Aleksandra Klimczak +8 more
doaj +1 more source
eLife, 2021 Gene knockout of the master regulator of mitochondrial fission, Drp1, prevents neoplastic transformation. Also, mitochondrial fission and its opposing process of mitochondrial fusion are emerging as crucial regulators of stemness.
Brian Spurlock +9 more
doaj +1 more source