Results 231 to 240 of about 546,265 (263)
Some of the next articles are maybe not open access.
Roots and stems: stem cells in cancer
Nature Medicine, 2006Cancer develops from normal tissues through the accumulation of genetic alterations that act in concert to confer malignant phenotypes. Although we have now identified some of the genes that when mutated initiate tumor formation and drive cancer progression, the identity of the cell population(s) susceptible to such transforming events remains ...
Kornelia, Polyak, William C, Hahn
openaire +2 more sources
2016
The cancer stem cell model in solid tumors has evolved significantly from the early paradigm shifting work highlighting parallels between the stem cell hierarchy in hematologic malignancies and solid tumors. Putative stem cells can dedifferentiated, be induced by context, and be the result of accumulated genetic mutations.
Wendy A, Woodward, Richard P, Hill
openaire +2 more sources
The cancer stem cell model in solid tumors has evolved significantly from the early paradigm shifting work highlighting parallels between the stem cell hierarchy in hematologic malignancies and solid tumors. Putative stem cells can dedifferentiated, be induced by context, and be the result of accumulated genetic mutations.
Wendy A, Woodward, Richard P, Hill
openaire +2 more sources
Cancer Stem Cells in Urooncology
Critical Reviews™ in Oncogenesis, 2019The aging of society has led to an increase in the incidence of urological cancers. Surgery, radiotherapy, and chemotherapeutic agents are widely used treatment options, in addition to minimally invasive new therapeutical approaches developed in the past decade.
Yuce Z., Cal C.
openaire +4 more sources
Cancer stem cells hypothesis and stem cells in head and neck cancers
Cancer Treatment Reviews, 2012There is increasing evidence that the growth and spread of cancer is driven by a small subpopulation of cancer cells, defined as cancer stem cells (CSCs). Recent data indicate that the initiation, growth, recurrence and metastasis of cancers are related to the behavior of a small population of malignant cells with properties of stem cells, and ...
mannelli, giuditta, GALLO, ORESTE
openaire +2 more sources
Epigenetic Signatures In Stem Cells And Cancer Stem Cells
Epigenomics, 2009The physiological properties of pluripotency in stem cells and the processes of cell specialization are governed by epigenetic mechanisms, as they are inheritable but not dependent on the cell genotype. There is cumulating evidence demonstrating the presence of cells with stem cell properties within tumors, suggesting that these cells are responsible ...
Hector, Hernandez-Vargas +3 more
openaire +2 more sources
Stem cells and colon cancer: The questionable cancer stem cell hypothesis
Gastroentérologie Clinique et Biologique, 2010The fine-tuning between cell proliferation and differentiation of self-renewing stem cells and pluripotent progenitors in gastric glands and colon epithelial crypts is coordinated by the mechanisms that regulate colon epithelial cell migration and guidance along the crypt axis.
openaire +2 more sources
Methods for PTEN in Stem Cells and Cancer Stem Cells
2015PTEN (phosphatase and tensin homologue) is the first tumor suppressor identified to have phosphatase activity and its gene is the second most frequently deleted or mutated tumor-suppressor gene associated with human cancers. Germline PTEN mutations are the cause of three inherited autosomal dominant disorders.
Suzanne, Schubbert +9 more
openaire +2 more sources
Stem Cells and Cancer Stem Cells
2015Nowadays, the definition “cancer stem cells” (CSCs) is widely accepted in the science community. Although, some authors think that this is a new definition in biology, the idea of CSCs has existed for more than 50 years. In recent years, the relations between “stem cells” and “cancer stem cells” gradually explored.
openaire +1 more source