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Clinical and Therapeutic Implications of Cancer Stem Cells

New England Journal of Medicine, 2019
Cancer Stem Cells Cancers arise in tissues that can replicate and self-renew. Like normal tissues, cancers can replenish themselves, grow, and metastasize because of stem cells that are similar to ...
Michael F Clarke
exaly   +2 more sources

Stem cells, cancer, and cancer stem cells [PDF]

open access: yesNature, 2001
Stem cell biology has come of age. Unequivocal proof that stem cells exist in the haematopoietic system has given way to the prospective isolation of several tissue-specific stem and progenitor cells, the initial delineation of their properties and expressed genetic programmes, and the beginnings of their utility in regenerative medicine.
T. Reya   +3 more
semanticscholar   +4 more sources

Cancer stem cells revisited

Nature Medicine, 2017
Eduard Batlle, Hans Clevers
exaly   +2 more sources

Cancer stem cells in TNBC.

Seminars in Cancer Biology, 2021
Triple-negative breast cancer (TNBC) is a broad collection of breast cancer that tests negative for estrogen receptors (ER), progesterone receptors (PR), and excess human epidermal growth factor receptor 2 (HER2) protein.
Zhan Hua, J. White, Jianjun Zhou
semanticscholar   +1 more source

β€œTo Be or Not to Be...” Cancer Stem Cells or Not Cancer Stem Cells..

Postdoc Journal, 2013
Cancer stem cells (CSCs) are defined as cancer cells with self-renewal capacity. These cells represent a small subpopulation endowed with the ability to form new tumors when injected in mice. Membrane markers and cancer stem cell assays have been used to identify and characterize these cells.
Bianca Ho   +2 more
openaire   +1 more source

Stem cells and cancer

Seminars in Cancer Biology, 2007
The cell of origin of cancer has been a strongly debated topic through out the history of cancer research. This review provides a historic framework and a synopsis of how the theories of cancer initiation and progression evolved from early times to the present day.
JeanMarie, Houghton   +3 more
openaire   +2 more sources

Roots and stems: stem cells in cancer

Nature Medicine, 2006
Cancer develops from normal tissues through the accumulation of genetic alterations that act in concert to confer malignant phenotypes. Although we have now identified some of the genes that when mutated initiate tumor formation and drive cancer progression, the identity of the cell population(s) susceptible to such transforming events remains ...
Kornelia, Polyak, William C, Hahn
openaire   +2 more sources

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