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2016
The cancer stem cell model in solid tumors has evolved significantly from the early paradigm shifting work highlighting parallels between the stem cell hierarchy in hematologic malignancies and solid tumors. Putative stem cells can dedifferentiated, be induced by context, and be the result of accumulated genetic mutations.
Wendy A, Woodward, Richard P, Hill
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The cancer stem cell model in solid tumors has evolved significantly from the early paradigm shifting work highlighting parallels between the stem cell hierarchy in hematologic malignancies and solid tumors. Putative stem cells can dedifferentiated, be induced by context, and be the result of accumulated genetic mutations.
Wendy A, Woodward, Richard P, Hill
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Cancer stem cells (CSCs) in cancer progression and therapy
Journal of Cellular Physiology, 2018Cancer stem cells (CSCs) are self‐renewable cell types that are identified in most types of liquid and solid cancers and contributed to tumor onset, expansion, resistance, recurrence, and metastasis after therapy.
M. Najafi, Bagher Farhood, K. Mortezaee
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Cancer Stem Cells in Urooncology
Critical Reviews™ in Oncogenesis, 2019The aging of society has led to an increase in the incidence of urological cancers. Surgery, radiotherapy, and chemotherapeutic agents are widely used treatment options, in addition to minimally invasive new therapeutical approaches developed in the past decade.
Yuce Z., Cal C.
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Breast cancer stem cells: Biology and therapeutic implications.
International Journal of Biochemistry and Cell Biology, 2019Breast cancer remains to be a dreadful disease even with several advancements in radiation and chemotherapies, owing to the drug resistance and tumor relapse caused by breast cancer stem cells.
R. Butti +4 more
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Cancer stem cells hypothesis and stem cells in head and neck cancers
Cancer Treatment Reviews, 2012There is increasing evidence that the growth and spread of cancer is driven by a small subpopulation of cancer cells, defined as cancer stem cells (CSCs). Recent data indicate that the initiation, growth, recurrence and metastasis of cancers are related to the behavior of a small population of malignant cells with properties of stem cells, and ...
mannelli, giuditta, GALLO, ORESTE
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Cancer stem cells in hepatocellular carcinoma — from origin to clinical implications
Nature reviews: Gastroenterology & hepatology, 2021T. Lee, X. Guan, Stephanie Ma
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Epigenetic Signatures In Stem Cells And Cancer Stem Cells
Epigenomics, 2009The physiological properties of pluripotency in stem cells and the processes of cell specialization are governed by epigenetic mechanisms, as they are inheritable but not dependent on the cell genotype. There is cumulating evidence demonstrating the presence of cells with stem cell properties within tumors, suggesting that these cells are responsible ...
Hector, Hernandez-Vargas +3 more
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Stem cells and colon cancer: The questionable cancer stem cell hypothesis
Gastroentérologie Clinique et Biologique, 2010The fine-tuning between cell proliferation and differentiation of self-renewing stem cells and pluripotent progenitors in gastric glands and colon epithelial crypts is coordinated by the mechanisms that regulate colon epithelial cell migration and guidance along the crypt axis.
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Cancer stem cells in solid tumours: accumulating evidence and unresolved questions
Nature Reviews. Cancer, 2008J. Visvader, G. Lindeman
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Methods for PTEN in Stem Cells and Cancer Stem Cells
2015PTEN (phosphatase and tensin homologue) is the first tumor suppressor identified to have phosphatase activity and its gene is the second most frequently deleted or mutated tumor-suppressor gene associated with human cancers. Germline PTEN mutations are the cause of three inherited autosomal dominant disorders.
Suzanne, Schubbert +9 more
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