Results 91 to 100 of about 980,429 (196)

NatD epigenetically activates FOXA2 expression to promote breast cancer progression by facilitating MMP14 expression

iScience
Summary: N-α-acetyltransferase D (NatD) mediates N-α-terminal acetylation of histone H4 (Nt-Ac-H4), but its role in breast cancer metastasis remains unknown.
Mengying Xing, Bing Yao, Jiaxuan Xu, Peifen Lu, Qixiang Li, Dongliang Wu, Bing Chen, Jiwu Wei, Lei Su, Quan Zhao   +9 more
doaj   +1 more source

Early Diagnosis of Alzheimer's disease by NIRF Spectroscopy and Nuclear Medicine-v.4.0 [PDF]

, 2011
There is an urgent need for the early detection of diseases such as Alzheimer’s (AD) and Cancers in order to enable their successful treatment. Cancer is the second major cause of death after Heart Disease, and AD is the third major cause of death
I Baianu
core   +1 more source

Overcoming resistance to arginine deprivation therapy using GC7 in pleural mesothelioma

iScience
Summary: Pleural mesothelioma is a highly chemotherapy-resistant cancer. Approximately 50% of mesotheliomas do not express argininosuccinate synthetase 1 (ASS1), the rate-limiting enzyme in arginine biosynthesis, making arginine depletion with pegylated ...
Josephine Carpentier, Marta Freitas, Valle Morales, Katiuscia Bianchi, John Bomalaski, Peter Szlosarek, Sarah A. Martin   +6 more
doaj   +1 more source

Reduced lung metastasis in endothelial cell-specific transforming growth factor β type II receptor-deficient mice with decreased CD44 expression

iScience
Summary: Transforming growth factor β (TGF-β) is abundantly present in the tumor microenvironment, contributing to cancer progression. However, the regulatory mechanism by which TGF-β affects vascular endothelial cells (ECs) in the tumor microenvironment
Kako Hanada, Yuki Saito, Takahiro Takagi, Mitsuki Go, Yota Nakano, Toshihiko Inagawa, Hideyo Hirai, Marcus Fruttiger, Susumu Itoh, Fumiko Itoh   +9 more
doaj   +1 more source

CDK7 is a novel therapeutic target in fibrolamellar carcinoma

iScience
Summary: Fibrolamellar Carcinoma (FLC) is a rare and deadly cancer that arises in young, otherwise healthy patients. For patients that cannot be treated with surgery, only 30%–45% survive to 5 years with current treatment options.
Manabu Nukaya, Patrick R. Carney, Crystal Cafferty, Katerina Zahed, Isabelle Yun, David P. Al-Adra, Noor A. Kazim, Alaa R. Farghli, Marina Chan, Austin Stram, Jeremy D. Kratz, Mark E. Berres, Andrew Yen, Taranjit S. Gujral, Praveen Sethupathy, Christopher A. Bradfield, Sean M. Ronnekleiv-Kelly   +16 more
doaj   +1 more source

An Introduction to the Mathematical Modeling in the Study of Cancer Systems Biology. [PDF]

Cancer Inform, 2018
Alameddine AK, Conlin F, Binnall B.
europepmc   +1 more source

External validation of Standardized KELIM and platinum-resistant recurrence scores in patients with advanced epithelial ovarian cancer

Journal of Ovarian Research
Background Neoadjuvant chemotherapy followed by interval debulking surgery is currently a common treatment option for advanced epithelial ovarian cancer (EOC).
Nina Oufkir, Roman Rouzier, Xavier Paoletti, Claire Bonneau   +3 more
doaj   +1 more source

CRA toolbox: software package for conditional robustness analysis of cancer systems biology models in MATLAB. [PDF]

BMC Bioinformatics, 2019
Bianconi F, Antonini C, Tomassoni L, Valigi P.   +3 more
europepmc   +1 more source

Integrative analysis and machine learning on cancer genomics data using the Cancer Systems Biology Database (CancerSysDB). [PDF]

BMC Bioinformatics, 2018
Krempel R, Kulkarni P, Yim A, Lang U, Habermann B, Frommolt P.   +5 more
europepmc   +1 more source

Cancer Systems Biology: a peek into the future of patient care? [PDF]

Nat Rev Clin Oncol, 2014
Werner HM, Mills GB, Ram PT.
europepmc   +1 more source