Results 91 to 100 of about 1,583,856 (340)
Taurine promotes glucagon‐like peptide‐1 secretion in enteroendocrine L cells
FEBS Letters, EarlyView.Taurine, a sulfur‐containing amino acid, is likely taken up by enteroendocrine L cells via the taurine transporter. This process increases the levels of cytosolic ATP. The increase in intracellular Ca2+ concentrations and glucagon‐like peptide‐1 secretion through membrane depolarization is caused by the closure of ATP‐sensitive potassium channels ...
Yuri Osuga +6 more
wiley +1 more source
What and How do Cancer Systems Biologists Explain? [PDF]
, 2018 In this article, we argue, first, that there are very different research projects that fall under the heading of “systems biology of cancer.” While they share some general features, they differ in their aims and theoretical commitments.
Bertolaso, Marta, Plutynski, Anya
core
Towards the First Principles in Biology and Cancer: New Vistas in Computational Systems Biology of Cancer [PDF]
Life, 2021 These days many leading scientists argue for a new paradigm for cancer research and propose a complex systems-view of cancer supported by empirical evidence. As an example, Thea Newman (2021) has applied “the lessons learned from physical systems to a critique of reductionism in medical research, with an emphasis on cancer”.
openaire +3 more sources
iScience, 2022 Summary: Met is an oncogene aberrantly activated in multiple cancers. Therefore, to better understand Met biology and its role in disease we applied the Mammalian Membrane Two-Hybrid (MaMTH) to generate a targeted interactome map of its interactions with
Shivanthy Pathmanathan +12 more
doaj
Paradox resolved: The allometric scaling of cancer risk across species [PDF]
arXiv, 2020 Understanding the cross-species behavior of cancer is important for uncovering fundamental mechanisms of carcinogenesis, and for translating results of model systems between species. One of the most famous interspecific considerations of cancer is Peto's paradox, which asserts that organisms with vastly different body mass are expected to have a vastly
arxiv
Perturbation Biology: inferring signaling networks in cellular systems [PDF]
, 2013 We present a new experimental-computational technology of inferring network models that predict the response of cells to perturbations and that may be useful in the design of combinatorial therapy against cancer. The experiments are systematic series of perturbations of cancer cell lines by targeted drugs, singly or in combination.
arxiv +1 more source
Molecular Oncology, EarlyView.The number of circulating tumor cells obtained from prostate cancer patients was increased approximately 5‐fold compared to regular CellSearch when processing 2 mL diagnostic leukapheresis material aliquots and increased by 44‐fold when processing 20 mL DLA aliquots using the flow enrichment target capture Halbach‐array.
Michiel Stevens +8 more
wiley +1 more source
Three-Dimensional Gradients of Cytokine Signaling between T Cells [PDF]
, 2015 Part of the numerical work was supported by the Helmholtz Aliance on Systems Biology (SB Cancer, Submodule V.7) and the ViroQuant ...
Friedmann, Elfriede +3 more
core +2 more sources
Hybrid Systems Modeling for (Cancer) Systems Biology [PDF]
, 2015 AbstractThe advent of biological data of increasingly higher resolution in space and time has triggered the use of dynamic models to explain and predict the evolution of biological systems over space and time. Computer-aided system modeling and analysis in biology has led to many new discoveries and explanations that would otherwise be intractable to ...
Dobbe, Roel I.J., Tomlin, Claire J.
openaire +1 more source
In the pursuit of complexity: Systems medicine in cancer biology [PDF]
Cancer Cell, 2006 Adler et al., in a paper appearing in Nature Genetics, exploited the intersect of genetic information from expression profiles with that from array comparative genomic hybridization in human breast cancers to identify genes that may induce the transcription of the prognostic "wound response" expression signature. The amplification of two genes, MYC and
Lance D. Miller +2 more
openaire +3 more sources