Results 71 to 80 of about 988,392 (288)
The Chernobyl Tissue Bank - A Repository for Biomaterial and Data Used in Integrative and Systems Biology Modeling the Human Response to Radiation [PDF]
, 2012 The only unequivocal radiological effect of the Chernobyl accident on human health is the increase in thyroid cancer in those exposed in childhood or early adolescence.
Bethel, J +7 more
core +2 more sources
FEBS Letters, EarlyView.Enteropathogenic E. coli (EPEC) infects the human intestinal epithelium, resulting in severe illness and diarrhoea. In this study, we compared the infection of cancer‐derived cell lines with human organoid‐derived models of the small intestine. We observed a delayed in attachment, inflammation and cell death on primary cells, indicating that host ...
Mastura Neyazi +5 more
wiley +1 more source
Computational methods in cancer gene networking [PDF]
, 2008 In the past few years, many high-throughput techniques have been developed and applied to biological studies. These techniques such as “next generation” genome sequencing, chip-on-chip, microarray and so on can be used to measure gene ...
Edwin Wang
core +2 more sources
Systems biology and cancer stem cells [PDF]
Journal of Cellular and Molecular Medicine, 2007 Introduction Molecular profiling for cancer classification Molecular profiling of cancer stem cells Emerging technologies for proteome characterization Biomolecular networks in cancer Perspective and concluding remarks AbstractThe identification, purification and characterization of cancer stem cells (CSCs) holds tremendous promise for improving the
Price, Nathan D +4 more
openaire +2 more sources
Organoids in pediatric cancer research
FEBS Letters, EarlyView.Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley +1 more source
iScience, 2023 Summary: Bromodomain-containing protein 8 (BRD8) is a subunit of the NuA4/TIP60-histone acetyltransferase complex. Although BRD8 has been considered to act as a co-activator of the complex, its biological role remains to be elucidated. Here, we uncovered
Kiyoshi Yamaguchi +20 more
doaj +1 more source
Modeling cancer metabolism on a genome scale [PDF]
, 2015 Cancer cells have fundamentally altered cellular metabolism that is associated with their tumorigenicity and malignancy. In addition to the widely studied Warburg effect, several new key metabolic alterations in cancer have been established over the last
Barbara Chaneton +8 more
core +1 more source
FEBS Letters, EarlyView.Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho +3 more
wiley +1 more source
Pan-cancer detection of driver genes at the single-patient resolution
Genome Medicine, 2021 Background Identifying the complete repertoire of genes that drive cancer in individual patients is crucial for precision oncology. Most established methods identify driver genes that are recurrently altered across patient cohorts. However, mapping these
Joel Nulsen +3 more
doaj +1 more source
High-resolution mapping of cancer cell networks using co-functional interactions. [PDF]
, 2018 Powerful new technologies for perturbing genetic elements have recently expanded the study of genetic interactions in model systems ranging from yeast to human cell lines.
Boyle, Evan A +2 more
core +1 more source