Results 51 to 60 of about 468,623 (293)

Systems Biology and Genomics of Breast Cancer [PDF]

Cold Spring Harbor Perspectives in Biology, 2010
It is now accepted that breast cancer is not a single disease, but instead it is composed of a spectrum of tumor subtypes with distinct cellular origins, somatic changes, and etiologies. Gene expression profiling using DNA microarrays has contributed significantly to our understanding of the molecular heterogeneity of breast tumor formation ...
Charles M, Perou, Anne-Lise, Børresen-Dale   +1 more
openaire   +2 more sources

Enteropathogenic E. coli shows delayed attachment and host response in human jejunum organoid‐derived monolayers compared to HeLa cells

FEBS Letters, EarlyView.
Enteropathogenic E. coli (EPEC) infects the human intestinal epithelium, resulting in severe illness and diarrhoea. In this study, we compared the infection of cancer‐derived cell lines with human organoid‐derived models of the small intestine. We observed a delayed in attachment, inflammation and cell death on primary cells, indicating that host ...
Mastura Neyazi, Pilar Samperio Ventayol, Natalie Burkard, Nicolas Schlegel, Carmen Aguilar, Sina Bartfeld   +5 more
wiley   +1 more source

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Multimodal analysis unveils tumor microenvironment heterogeneity linked to immune activity and evasion

iScience
Summary: The cellular and molecular heterogeneity of tumors is a major obstacle to cancer immunotherapy. Here, we use a systems biology approach to derive a signature of the main sources of heterogeneity in the tumor microenvironment (TME) from lung ...
Óscar Lapuente-Santana, Gregor Sturm, Joan Kant, Markus Ausserhofer, Constantin Zackl, Maria Zopoglou, Nicholas McGranahan, Dietmar Rieder, Zlatko Trajanoski, Noel Filipe da Cunha Carvalho de Miranda, Federica Eduati, Francesca Finotello   +11 more
doaj   +1 more source

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

Experimental assessment of AI-based interactome mapping

Nature Communications
Genotype-phenotype relationships are mediated through intricate networks of physical and functional interactions among macromolecules. Knowledge of the interactome is vital to understand and model genetics and cellular biology.
Luke Lambourne, Anupama Yadav, Yang Wang, Alice Desbuleux, Dae-Kyum Kim, Florent Laval, Kerstin Spirohn-Fitzgerald, Tiziana Cafarelli, Carles Pons, István A. Kovács, Noor Jailkhani, Sadie Schlabach, David De Ridder, Katja Luck, Vladimir V. Botchkarev, Olivia Debnath, Wenting Bian, Yun Shen, Zhipeng Yang, Miles W. Mee, Mohamed Helmy, Yves Jacob, Irma Lemmens, Thomas Rolland, Gregory G. McClain, Atina G. Coté, Marinella Gebbia, Nishka Kishore, Jennifer J. Knapp, Joseph C. Mellor, Gonen Memisoglu, Jüri Reimand, Jan Tavernier, Michael E. Cusick, Quan Zhong, Patrick Aloy, Tong Hao, Benoit Charloteaux, Frederick P. Roth, Javier De Las Rivas, Pascal Falter-Braun, David E. Hill, Michael A. Calderwood, Jean-Claude Twizere, Marc Vidal   +44 more
doaj   +1 more source

Computational methods in cancer gene networking

, 2008
In the past few years, many high-throughput techniques have been developed and applied to biological studies. These techniques such as “next generation” genome sequencing, chip-on-chip, microarray and so on can be used to measure gene ...
Wang, Edwin, Edwin Wang
core   +2 more sources

Computational Tactics for Precision Cancer Network Biology

, 2022
Network biology has garnered tremendous attention in understanding complex systems of cancer, because the mechanisms underlying cancer involve the perturbations in the specific function of molecular networks, rather than a disorder of a single gene.
Miyano, Satoru, Heewon Park, Satoru Miyano, Park, Heewon   +3 more
core   +1 more source

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

Metabolic network reconstruction of Chlamydomonas offers insight into light‐driven algal metabolism

Molecular Systems Biology, 2011
Metabolic network reconstruction encompasses existing knowledge about an organism's metabolism and genome annotation, providing a platform for omics data analysis and phenotype prediction.
Roger L Chang, Lila Ghamsari, Ani Manichaikul, Erik F Y Hom, Santhanam Balaji, Weiqi Fu, Yun Shen, Tong Hao, Bernhard Ø Palsson, Kourosh Salehi‐Ashtiani, Jason A Papin   +10 more
doaj   +1 more source