Results 41 to 50 of about 468,623 (293)
A Boolean-based systems biology approach to predict novel genes associated with cancer: Application to colorectal cancer [PDF]
, 2011 Background\ud \ud Cancer has remarkable complexity at the molecular level, with multiple genes, proteins, pathways and regulatory interconnections being affected.
Shivashankar H Nagaraj +3 more
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Organicism and Reductionism in Cancer Research: Towards a Systemic Approach [PDF]
, 2007 In recent cancer research, strong and apparently conflicting epistemological stances have been advocated by different research teams in a mist of an ever-growing body of knowledge ignited by ever-more perplexing and non-conclusive experimental facts: in ...
Malaterre, Christophe +1 more
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, 2010 Systems biology takes an interdisciplinary approach to the systematic study of complex interactions in biological systems. This approach seeks to decipher the emergent behaviors of complex systems rather than focusing only on their constituent properties.
Baltrusch, S +9 more
core +3 more sources
, 2021 These days many leading scientists argue for a new paradigm for cancer research and propose a complex systems-view of cancer supported by empirical evidence.
Aleš Prokop
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Nature Communications, 2016 Phenotypic and genetic intra-tumor heterogeneity have an important role in cancer progression and therapeutic resistance. Here, the authors show that phenotypically variable tumor subpopulations exhibit higher metastatic potential and display enhanced ...
Alexander Nguyen +3 more
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Novel Monte Carlo approach quantifies data assemblage utility and reveals power of integrating molecular and clinical information for cancer prognosis [PDF]
, 2015 WV is a SULSA Systems Biology Prize PhD Student; VAS is supported by the BBSRC Research Council [grant number BB/F001398/1] and Medical Research Scotland [grant number FRG353].
Smith, V. Anne +7 more
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Systems Biology of the Cancer Cell
Annual Review of Biomedical EngineeringQuestions in cancer have engaged systems biologists for decades. During that time, the quantity of molecular data has exploded, but the need for abstractions, formal models, and simplifying insights has remained the same. This review brings together classic breakthroughs and recent findings in the field of cancer systems biology, focusing on cancer ...
Kevin A, Janes, Matthew J, Lazzara
openaire +2 more sources
Finite universe of discourse. The systems biology of Walter Elsasser (1904-1991). [PDF]
, 2008 Walter Elsasser (1904-1991), an eminent quantum physicist and geophysicist, was also active in theoretical biology over a 35-year period from the early 1950s to the late 1980s.
Gatherer, Derek
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Pediatric Blood &Cancer, EarlyView.ABSTRACT Pediatric gastroenteropancreatic neuroendocrine neoplasms (GEP‐NENs) are extremely rare and clinically heterogeneous. Management has largely been extrapolated from adult practice. This European Standard Clinical Practice Guideline (ESCP), developed by the EXPeRT network in collaboration with adult NEN experts, provides (adult) evidence ...
Michaela Kuhlen +23 more
wiley +1 more source
High-resolution characterization of gene function using single-cell CRISPR tiling screen
Nature Communications, 2021 Identifying functional domains and genetic regulatory mechanisms is essential for developing new therapies. Here the authors present sc-Tiling, single-cell high-density CRISPR tiling screening for functional domain characterization.
Lu Yang +25 more
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