Results 41 to 50 of about 479,650 (261)

Central Nervous System Tumors Among Infants in Canada: A Report From CYP‐C

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Central nervous system (CNS) tumors in infants are rare, pose unique clinical challenges, and lack large‐scale evidence‐based data to guide management. This study seeks to describe CNS tumors in Canadian infants and to compare their outcomes with those of older children.
Samuel Sassine, Hallie Coltin, Sylvia Cheng, Lucie Lafay‐Cousin, Vanan Issai Magimairajan, Craig Erker, Stéphanie Vairy, Lynette Bowes, Adam Fleming, Donna Johnston, Sarah McKillop, Roona Sinha, Julie Bennett, Christina Coleman, Laura Wheaton, Shayna Zelcer, Samuele Renzi, Thai Hoa Tran   +17 more
wiley   +1 more source

Multimodal analysis unveils tumor microenvironment heterogeneity linked to immune activity and evasion

iScience
Summary: The cellular and molecular heterogeneity of tumors is a major obstacle to cancer immunotherapy. Here, we use a systems biology approach to derive a signature of the main sources of heterogeneity in the tumor microenvironment (TME) from lung ...
Óscar Lapuente-Santana, Gregor Sturm, Joan Kant, Markus Ausserhofer, Constantin Zackl, Maria Zopoglou, Nicholas McGranahan, Dietmar Rieder, Zlatko Trajanoski, Noel Filipe da Cunha Carvalho de Miranda, Federica Eduati, Francesca Finotello   +11 more
doaj   +1 more source

Systems biology and cancer stem cells [PDF]

Journal of Cellular and Molecular Medicine, 2007
Introduction Molecular profiling for cancer classification Molecular profiling of cancer stem cells Emerging technologies for proteome characterization Biomolecular networks in cancer Perspective and concluding remarks AbstractThe identification, purification and characterization of cancer stem cells (CSCs) holds tremendous promise for improving the
Price, Nathan D, Foltz, Greg, Madan, Anup, Hood, Leroy, Tian, Qiang   +4 more
openaire   +2 more sources

Comparative Drug Response Profiling in Neuroblastoma Cell Lines and Patient‐Derived Tumor Organoids

Pediatric Blood &Cancer, EarlyView.
ABSTRACT High‐risk neuroblastoma remains a leading cause of pediatric cancer mortality, and improved preclinical models are needed to guide therapeutic developments. We screened seven high‐risk neuroblastoma cell lines and three patient‐derived tumor organoids with 528 compounds alongside bone marrow controls, and compared them with external datasets ...
Krzysztof Wierbiłowicz, Se Whee Sammy Park, Aironas Los, Ernest Liu, Nona Struyf, Tom Erkers, Sören Lehmann, Jan J. Molenaar, Jakob Stenman, Olli Kallioniemi, Päivi Östling, Brinton Seashore‐Ludlow, Kasper Karlsson   +12 more
wiley   +1 more source

Experimental assessment of AI-based interactome mapping

Nature Communications
Genotype-phenotype relationships are mediated through intricate networks of physical and functional interactions among macromolecules. Knowledge of the interactome is vital to understand and model genetics and cellular biology.
Luke Lambourne, Anupama Yadav, Yang Wang, Alice Desbuleux, Dae-Kyum Kim, Florent Laval, Kerstin Spirohn-Fitzgerald, Tiziana Cafarelli, Carles Pons, István A. Kovács, Noor Jailkhani, Sadie Schlabach, David De Ridder, Katja Luck, Vladimir V. Botchkarev, Olivia Debnath, Wenting Bian, Yun Shen, Zhipeng Yang, Miles W. Mee, Mohamed Helmy, Yves Jacob, Irma Lemmens, Thomas Rolland, Gregory G. McClain, Atina G. Coté, Marinella Gebbia, Nishka Kishore, Jennifer J. Knapp, Joseph C. Mellor, Gonen Memisoglu, Jüri Reimand, Jan Tavernier, Michael E. Cusick, Quan Zhong, Patrick Aloy, Tong Hao, Benoit Charloteaux, Frederick P. Roth, Javier De Las Rivas, Pascal Falter-Braun, David E. Hill, Michael A. Calderwood, Jean-Claude Twizere, Marc Vidal   +44 more
doaj   +1 more source

Metabolic network reconstruction of Chlamydomonas offers insight into light‐driven algal metabolism

Molecular Systems Biology, 2011
Metabolic network reconstruction encompasses existing knowledge about an organism's metabolism and genome annotation, providing a platform for omics data analysis and phenotype prediction.
Roger L Chang, Lila Ghamsari, Ani Manichaikul, Erik F Y Hom, Santhanam Balaji, Weiqi Fu, Yun Shen, Tong Hao, Bernhard Ø Palsson, Kourosh Salehi‐Ashtiani, Jason A Papin   +10 more
doaj   +1 more source

Referral Patterns and Diagnostic Timeliness in Pediatric Cancer: A Hospital‐Based Study in Indonesia

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Timely diagnosis and treatment are critical for improving survival among children with cancer. In low‐ and middle‐income countries (LMICs), delays are common and may be influenced by fragmented referral pathways and diagnostic limitations.
Nur Melani Sari, Regina Hadi Putri, Fatimah Assyifa, Judith Spijkerman, Gertjan Johannes Kaspers, Susi Susanah   +5 more
wiley   +1 more source

Pan-cancer detection of driver genes at the single-patient resolution

Genome Medicine, 2021
Background Identifying the complete repertoire of genes that drive cancer in individual patients is crucial for precision oncology. Most established methods identify driver genes that are recurrently altered across patient cohorts. However, mapping these
Joel Nulsen, Hrvoje Misetic, Christopher Yau, Francesca D. Ciccarelli   +3 more
doaj   +1 more source

Engineering Simulations for Cancer Systems Biology [PDF]

Current Drug Targets, 2012
Computer simulation can be used to inform in vivo and in vitro experimentation, enabling rapid, low-cost hypothesis generation and directing experimental design in order to test those hypotheses. In this way, in silico models become a scientific instrument for investigation, and so should be developed to high standards, be carefully calibrated and ...
James, Bown, Paul S, Andrews, Yusuf, Deeni, Alexey, Goltsov, Michael, Idowu, Fiona A C, Polack, Adam T, Sampson, Mark, Shovman, Susan, Stepney   +8 more
openaire   +2 more sources

Bone and Soft Tissue Neoplasms in Infants Versus Older Children: A Report From the Cancer in Young People in Canada Program

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background and Aims Infant bone and soft tissue neoplasms present distinct clinical challenges and lack large‐scale data to inform treatment decisions. This study aims to characterize bone and soft tissue neoplasms in infants in Canada and to compare their outcomes with those of older pediatric patients.
Samuel Sassine, Hallie Coltin, Maria Kondyli, Monia Marzouki, Nicolas Prud'homme, Nida Usmani, Rebecca J. Deyell, Lesleigh Abbott, Tony H. Truong, Sapna Oberoi, Ketan Kulkarni, Josée Brossard, Lynette Bowes, Paul Gibson, Sarah McKillop, Roona Sinha, Lillian Sung, Catherine Vezina, Laura Wheaton, Alexandra P. Zorzi, Marie‐Claude Pelland‐Marcotte, Thai Hoa Tran   +21 more
wiley   +1 more source