Results 21 to 30 of about 988,392 (288)
Cellular and molecular effects of PNCK, a non-canonical kinase target in renal cell carcinoma
iScience, 2022 Summary: Renal cell carcinoma (RCC) is a fatal disease when advanced. While immunotherapy and tyrosine kinase inhibitor-based combinations are associated with improved survival, the majority of patients eventually succumb to the disease.
Derek J. Essegian +4 more
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Computational and systems biology of cancer [PDF]
Computational and Systems Oncology, 2020 Ever since the war on cancer was declared in 1971, there has been an explosion in our understanding of this diverse group of diseases. The application of molecular genetics and molecular biology technologies have enabled a deep understanding of the genetic, epigenetic, signaling cascades, survival pathways, and invasive mechanisms that underlie the ...
openaire +1 more source
Systems Biology of Cancer Metastasis [PDF]
Cell Systems, 2019 Cancer metastasis is no longer viewed as a linear cascade of events but rather as a series of concurrent, partially overlapping processes, as successfully metastasizing cells assume new phenotypes while jettisoning older behaviors. The lack of a systemic understanding of this complex phenomenon has limited progress in developing treatments for ...
Yasir, Suhail +6 more
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RUNX1 colludes with NOTCH1 to reprogram chromatin in T cell acute lymphoblastic leukemia
iScience, 2023 Summary: Runt-related transcription factor 1 (RUNX1) is oncogenic in diverse types of leukemia and epithelial cancers where its expression is associated with poor prognosis. Current models suggest that RUNX1 cooperates with other oncogenic factors (e.g.,
Rashedul Islam +8 more
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Stratification of patients with clear cell renal cell carcinoma to facilitate drug repositioning
iScience, 2021 Summary: Clear cell renal cell carcinoma (ccRCC) is the most common histological type of kidney cancer and has high heterogeneity. Stratification of ccRCC is important since distinct subtypes differ in prognosis and treatment.
Xiangyu Li +12 more
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Communications Biology, 2023 The discovery and characterization of antigen-specific CD8+ T cell clonotypes typically involves the labor-intensive synthesis and construction of peptide-MHC tetramers.
William Chour +24 more
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iScience, 2021 Summary: The patient-derived xenograft (PDX) model is a versatile tool used to study the tumor microenvironment (TME). However, limited studies have described multi-tumor PDX screening strategies to detect hub regulators during cancer-stroma interaction.
Kuniyo Sueyoshi +12 more
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Genome Biology, 2019 The Network of Cancer Genes (NCG) is a manually curated repository of 2372 genes whose somatic modifications have known or predicted cancer driver roles.
Dimitra Repana +8 more
doaj +1 more source
A signaling visualization toolkit to support rational design of combination therapies and biomarker discovery: SiViT [PDF]
, 2016 Targeted cancer therapy aims to disrupt aberrant cellular signalling pathways. Biomarkers are surrogates of pathway state, but there is limited success in translating candidate biomarkers to clinical practice due to the intrinsic complexity of pathway ...
Boiko, Andrei +6 more
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Neural signaling modulates metabolism of gastric cancer
iScience, 2021 Summary: Tumors comprise cancer cells and the associated stromal and immune/inflammatory cells, i.e., tumor microenvironment (TME). Here, we identify a metabolic signature of human and mouse model of gastric cancer and show that vagotomy in the mouse ...
Hanne-Line Rabben +10 more
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