Results 11 to 20 of about 15,478 (246)

Systems Approaches to Cancer Biology [PDF]

Cancer Research, 2016
Abstract Cancer systems biology aims to understand cancer as an integrated system of genes, proteins, networks, and interactions rather than an entity of isolated molecular and cellular components. The inaugural Systems Approaches to Cancer Biology Conference, cosponsored by the Association of Early Career Cancer Systems Biologists and ...
Archer, Tenley C, Fertig, Elana J, Gosline, Sara JC, Hafner, Marc, Hughes, Shannon K, Joughin, Brian A, Meyer, Aaron S, Piccolo, Stephen R, Shajahan-Haq, Ayesha N   +8 more
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Systems Biology: Confronting the Complexity of Cancer [PDF]

Cancer Research, 2011
Abstract The AACR-NCI Conference “Systems Biology: Confronting the Complexity of Cancer” took place from February 27 to March 2, 2011, in San Diego, CA. Several themes resonated during the meeting, notably (i) the need for better methods to distill insights from large-scale networks, (ii) the importance of integrating multiple data types
Andrew J, Gentles, Daniel, Gallahan
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Systems biology based drug repositioning for development of cancer therapy

, 2021
Drug repositioning is a powerful method that can assists the conventional drug discovery process by using existing drugs for treatment of a disease rather than its original indication.
Turanli, B., Turanli, Beste, Altay, O., Mardinoglu, A., Nielsen, Jens B, Nielsen, J., Turanli, Beste,, Uhlen, M, Mardinoglu, Adil,, Nielsen, J, Uhlen, Mathias,, Arga, Kazim Y., Bor\ue9n, Jan, Turkez, Hasan, Mardinoglu, Adil, Borén, J, Uhlen, Mathias, Uhlen, M., Turanli, B, Turkez, H., Arga, KY, Altay, Ozlem, Altay, Ozlem,, Arga, K. Y., Mardinoglu, A, Borén, Jan,, Arga, Kazim Y.,, Altay, O, Nielsen, Jens B,, Turkez, Hasan,   +29 more
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Tumor microenvironment mimicking 3D models unveil the multifaceted effects of SMAC mimetics

iScience, 2023
Summary: Small molecule IAP antagonists - SMAC mimetics (SM) - are being developed as an anticancer therapy. SM therapy was demonstrated not only to sensitize tumor cells to TNFα-mediated cell death but also to exert immunostimulatory properties.
Catarina Pinto, Ksenija Slavic-Obradovic, Daniela Fürweger, Barbara Thaler, Abdallah Souabni, Sebastian Carotta, Martin Aichinger, Ulrich Reiser, Maria Antonietta Impagnatiello, Iñigo Tirapu   +9 more
doaj   +1 more source

Comparative assessment of genes driving cancer and somatic evolution in non-cancer tissues: an update of the Network of Cancer Genes (NCG) resource

Genome Biology, 2022
Background Genetic alterations of somatic cells can drive non-malignant clone formation and promote cancer initiation. However, the link between these processes remains unclear and hampers our understanding of tissue homeostasis and cancer development ...
Lisa Dressler, Michele Bortolomeazzi, Mohamed Reda Keddar, Hrvoje Misetic, Giulia Sartini, Amelia Acha-Sagredo, Lucia Montorsi, Neshika Wijewardhane, Dimitra Repana, Joel Nulsen, Jacki Goldman, Marc Pollitt, Patrick Davis, Amy Strange, Karen Ambrose, Francesca D. Ciccarelli   +15 more
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Computational and systems biology of cancer [PDF]

Computational and Systems Oncology, 2020
Ever since the war on cancer was declared in 1971, there has been an explosion in our understanding of this diverse group of diseases. The application of molecular genetics and molecular biology technologies have enabled a deep understanding of the genetic, epigenetic, signaling cascades, survival pathways, and invasive mechanisms that underlie the ...
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Pioneer factors in development and cancer

iScience, 2021
Summary: Transcription factors (TFs) are essential mediators of epigenetic regulation and modifiers of penetrance. Studies from the past decades have revealed a sub-class of TF that is capable of remodeling closed chromatin states through targeting ...
Benjamin D. Sunkel, Benjamin Z. Stanton
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Systems Biology of Cancer Metastasis [PDF]

Cell Systems, 2019
Cancer metastasis is no longer viewed as a linear cascade of events but rather as a series of concurrent, partially overlapping processes, as successfully metastasizing cells assume new phenotypes while jettisoning older behaviors. The lack of a systemic understanding of this complex phenomenon has limited progress in developing treatments for ...
Yasir, Suhail, Margo P, Cain, Kiran, Vanaja, Paul A, Kurywchak, Andre, Levchenko, Raghu, Kalluri, , Kshitiz   +6 more
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Cellular and molecular effects of PNCK, a non-canonical kinase target in renal cell carcinoma

iScience, 2022
Summary: Renal cell carcinoma (RCC) is a fatal disease when advanced. While immunotherapy and tyrosine kinase inhibitor-based combinations are associated with improved survival, the majority of patients eventually succumb to the disease.
Derek J. Essegian, Valery Chavez, Floritza Bustamante, Stephan C. Schürer, Jaime R. Merchan   +4 more
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RUNX1 colludes with NOTCH1 to reprogram chromatin in T cell acute lymphoblastic leukemia

iScience, 2023
Summary: Runt-related transcription factor 1 (RUNX1) is oncogenic in diverse types of leukemia and epithelial cancers where its expression is associated with poor prognosis. Current models suggest that RUNX1 cooperates with other oncogenic factors (e.g.,
Rashedul Islam, Catherine E. Jenkins, Qi Cao, Jasper Wong, Misha Bilenky, Annaïck Carles, Michelle Moksa, Andrew P. Weng, Martin Hirst   +8 more
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