Results 91 to 100 of about 468,623 (293)

A model of estrogen-related gene expression reveals non-linear effects in transcriptional response to tamoxifen [PDF]

, 2012
SynthSys is a Centre for Integrative Systems Biology (CISB) funded by BBSRC and EPSRC, reference BB/D019621/1.Background: Estrogen receptors alpha (ER) are implicated in many types of female cancers, and are the common target for anti-cancer therapy ...
Harrison, David J, Kenneth Macleod, Yamaguchi, Azusa, Macleod, Kenneth, Galina Lebedeva, David J Harrison, Lebedeva, Galina, Langdon, Simon P., Langdon, Simon P, Azusa Yamaguchi, Harrison, David J., Simon P Langdon   +11 more
core   +1 more source

The ubiquitin‐proteasome system and autophagy as guardians of the cellular proteome

FEBS Letters, EarlyView.
This Perspective covers the three principles governing the crosstalk between the ubiquitin‐proteasome system and autophagy in cellular proteostasis: (1) a shared ubiquitin code routing substrates via shuttle factors or autophagy receptors; (2) spatial compartmentalization into phase‐separated degradation hubs and organelle‐specific modules (exemplified
Ivan Dikic
wiley   +1 more source

The role of kisspeptin system in cancer biology

Critical Reviews in Oncology/Hematology, 2019
Kisspeptins are a family of neuropeptides that are known to be critical in puberty initiation and ovulation. Apart from that kisspeptin derived peptides (KPs) are also known for their antimetastatic activities in several malignancies. Herein we report recent evidence of the role of kisspeptins in cancer biology and we examine the prospective of ...
Martha Stathaki, Maria Evanthia Stamatiou, George Magioris, Spyridon Simantiris, Nikolaos Syrigos, Spyridon Dourakis, Michael Koutsilieris, Athanasios Armakolas   +7 more
openaire   +3 more sources

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

Rapid mechanical phenotyping of breast cancer cells based on stochastic intracellular fluctuations

iScience
Summary: Predicting the phenotypic impact of genetic variants and treatments is crucial in cancer genetics and precision oncology. Here, we have developed a noise decorrelation method that enables quantitative phase imaging (QPI) with the capability for ...
Álvaro Cano, Marina L. Yubero, Carmen Millá, Verónica Puerto-Belda, Jose J. Ruz, Priscila M. Kosaka, Montserrat Calleja, Marcos Malumbres, Javier Tamayo   +8 more
doaj   +1 more source

AKT isoform-specific expression and activation across cancer lineages

BMC Cancer, 2018
Background Aberrant AKT activation is prevalent across human cancer lineages, providing an important therapeutic target. AKT comprises three isoforms that mediate critical non-redundant, even opposing functions in cancer pathophysiology.
Jue Wang, Wei Zhao, Huifang Guo, Yong Fang, Sarah Elizabeth Stockman, Shanshan Bai, Patrick Kwok-Shing Ng, Yang Li, Qinghua Yu, Yiling Lu, Kang Jin Jeong, Xiaohua Chen, Meng Gao, Jiyong Liang, Wentao Li, Xingsong Tian, Eric Jonasch, Gordon B. Mills, Zhiyong Ding   +18 more
doaj   +1 more source

Smell Detection Agent Optimisation Framework and Systems Biology Approach to Detect Dys-Regulated Subnetwork in Cancer Data

, 2021
Network biology has become a key tool in unravelling the mechanisms of complex diseases. Detecting dys-regulated subnetworks from molecular networks is a task that needs efficient computational methods.
Vinod Chandra S. Sukumara Pillai, Suma L. Sivan   +1 more
core   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Advancing Cancer Systems Biology: Introducing the Center for the Development of a Virtual Tumor, CViT [PDF]

, 2011
Integrative cancer biology research relies on a variety of data-driven computational modeling and simulation methods and techniques geared towards gaining new insights into the complexity of biological processes that are of critical importance for cancer
Zhang, Le, Deisboeck, Thomas, Martin, Sean   +2 more
core   +1 more source

Three phosphatase families form a community: The phosphohydrolases that act upon inositol pyrophosphates

FEBS Letters, EarlyView.
Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley   +1 more source