Results 101 to 110 of about 1,632,468 (362)
ORF Capture-Seq as a versatile method for targeted identification of full-length isoforms
Nature Communications, 2020 Most human protein-coding genes are expressed as multiple isoforms. Here the authors present ORF Capture-seq that uses cloned ORFs as probes to capture and sequence full length transcript sequences.
Gloria M. Sheynkman +13 more
doaj +1 more source
Nature Communications, 2022 Current high-dimension imaging data analysis methods are technology-specific and require multiple tools, restricting analytical scalability and result reproducibility.
Michele Bortolomeazzi +10 more
doaj +1 more source
, 2019 Cancer cells can acquire a spectrum of stable hybrid epithelial/mesenchymal (E/M) states during epithelial-mesenchymal transition (EMT). Cells in these hybrid E/M phenotypes often combine epithelial and mesenchymal features and tend to migrate ...
Bocci, Federico +7 more
core +1 more source
The role of kisspeptin system in cancer biology
Critical Reviews in Oncology/Hematology, 2019 Kisspeptins are a family of neuropeptides that are known to be critical in puberty initiation and ovulation. Apart from that kisspeptin derived peptides (KPs) are also known for their antimetastatic activities in several malignancies. Herein we report recent evidence of the role of kisspeptins in cancer biology and we examine the prospective of ...
Martha Stathaki +7 more
openaire +3 more sources
Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation
FEBS Letters, EarlyView.Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe +3 more
wiley +1 more source
Spatial-temporal dynamics of a microbial cooperative behavior resistant to cheating
Nature Communications, 2022 Bacteria often live in densely packed, spatially-structured communities; however, much of our understanding of their behavior stems from studies in liquid culture. Here, Monaco et al.
Hilary Monaco +7 more
doaj +1 more source
Precision medicine and molecular imaging: new targeted approaches toward cancer therapeutic and diagnosis [PDF]
, 2016 : This paper presents a review of the importance and role of precision medicine and molecular imaging technologies in cancer diagnosis with therapeutics and diagnostics purposes.
Alipour, Zeinab +4 more
core +1 more source
Integration of omics: more than the sum of its parts [PDF]
, 2016 Genome scale data on biological systems has increasingly become available by sequencing of DNA and RNA, and by mass spectrometric quantification of proteins and metabolites.
Edward M Driggers, Joerg Martin Buescher
core +1 more source
Function‐driven design of a surrogate interleukin‐2 receptor ligand
FEBS Letters, EarlyView.Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang +9 more
wiley +1 more source
Plasma Exosome Profiling of Cancer Patients by a Next Generation Systems Biology Approach
Scientific Reports, 2017 Technologies capable of characterizing the full breadth of cellular systems need to be able to measure millions of proteins, isoforms, and complexes simultaneously.
V. Domenyuk +20 more
semanticscholar +1 more source