Results 101 to 110 of about 990,872 (342)

Recent Developments in Cancer Systems Biology: Lessons Learned and Future Directions. [PDF]

J Pers Med, 2021
Arga KY, Sinha R.
europepmc   +1 more source

Supplementary Figure 1 from A Systems Biology Approach Identifies SART1 as a Novel Determinant of Both 5-Fluorouracil and SN38 Drug Resistance in Colorectal Cancer

, 2023
Wendy L. Allen, Leanne Stevenson, Vicky M. Coyle, Puthen V. Jithesh, Irina Proutski, Gail Carson, Melita A. Gordon, Heinz-Josef D. Lenz, Sandra Van Schaeybroeck, Daniel B. Longley, Patrick G. Johnston   +10 more
openalex   +1 more source

Predictive and Personalized Medicine with Systems Biology Solutions [PDF]

, 2011
poster abstractSystems biology refers to the use of systems engineering and systems science techniques to the understanding of biological systems. At Indiana Center for Systems Biology and Personalized Medicine (ICSBPM), we are particularly interested in
Chen, Jake Y., Wu, Xiaogang
core  

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source

Cell density–dependent nuclear‐cytoplasmic shuttling of SETDB1 integrates with Hippo signaling to regulate YAP1‐mediated transcription

FEBS Letters, EarlyView.
At low cell density, SETDB1 and YAP1 accumulate in the nucleus. As cell density increases, the Hippo pathway is gradually activated, and SETDB1 is associated with increased YAP1 phosphorylation. At high cell density, phosphorylated YAP1 is sequestered in the cytoplasm, while SETDB1 becomes polyubiquitinated and degraded by the ubiquitin–proteasome ...
Jaemin Eom, Jaewoong Jang, Jung Sun Park, Yong‐Kook Kang   +3 more
wiley   +1 more source

Navigating Multi-Scale Cancer Systems Biology Towards Model-Driven Clinical Oncology and Its Applications in Personalized Therapeutics. [PDF]

Front Oncol, 2021
Gondal MN, Chaudhary SU.
europepmc   +1 more source

Novel systems biology tools for the identification of biomarkers and drug targets in cancer research.

, 2022
L. Valcarcel
openalex   +2 more sources

Machine Learning for Integrating Data in Biology and Medicine: Principles, Practice, and Opportunities

, 2018
New technologies have enabled the investigation of biology and human health at an unprecedented scale and in multiple dimensions. These dimensions include a myriad of properties describing genome, epigenome, transcriptome, microbiome, phenotype, and ...
Goldenberg, Anna, Hoffman, Michael M., Leskovec, Jure, Nguyen, Francis, Wang, Bo, Zitnik, Marinka   +5 more
core   +1 more source

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source

Dissecting regulated cell death states and transformation mechanisms in the evolutionary trajectory of 30 cancers

iScience
Summary: Cancer is a heterogeneous disease driven by dysregulated cell death, which influences tumor progression and treatment responses. It is important to construct a systematic landscape that characterizes the dysregulation of regulated cell death ...
Yunpeng Zhang, Qi Ou, Congxue Hu, Chuo Peng, Tengyue Li, Xiaozhi Huang, Kuan Yang, Liyuan Li, Xia Li, Yingqi Xu   +9 more
doaj   +1 more source