Results 101 to 110 of about 1,564,848 (340)

Metabolic network reconstruction of Chlamydomonas offers insight into light‐driven algal metabolism

Molecular Systems Biology, 2011
Metabolic network reconstruction encompasses existing knowledge about an organism's metabolism and genome annotation, providing a platform for omics data analysis and phenotype prediction.
Roger L Chang, Lila Ghamsari, Ani Manichaikul, Erik F Y Hom, Santhanam Balaji, Weiqi Fu, Yun Shen, Tong Hao, Bernhard Ø Palsson, Kourosh Salehi‐Ashtiani, Jason A Papin   +10 more
doaj   +1 more source

Disruption of SETD3‐mediated histidine‐73 methylation by the BWCFF‐associated β‐actin G74S mutation

FEBS Letters, EarlyView.
The β‐actin G74S mutation causes altered interaction of actin with SETD3, reducing histidine‐73 methylation efficiency and forming two distinct actin variants. The variable ratio of these variants across cell types and developmental stages contributes to tissue‐specific phenotypical changes. This imbalance may impair actin dynamics and mechanosensitive
Anja Marquardt, Marcus S. Münchhoff, Jacqueline Krohn, Philip M. Palarz, Manuel H. Taft, Johannes N. Greve, Nataliya Di Donato, Falk F. R. Buettner, Dietmar J. Manstein   +8 more
wiley   +1 more source

Fractal analysis in a systems biology approach to cancer [PDF]

Seminars in Cancer Biology, 2011
Cancer is a highly complex disease due to the disruption of tissue architecture. Thus, tissues, and not individual cells, are the proper level of observation for the study of carcinogenesis. This paradigm shift from a reductionist approach to a systems biology approach is long overdue.
BIZZARRI, Mariano, Alessandro Giuliani, CUCINA, Alessandra, D'ANSELMI, FABRIZIO, A. M. Soto, C. Sonnenschein   +5 more
openaire   +4 more sources

Implications of the hybrid epithelial/mesenchymal phenotype in metastasis

Frontiers in Oncology, 2015
Understanding cell-fate decisions during tumorigenesis and metastasis is a major challenge in modern cancer biology. One canonical cell-fate decision that cancer cells undergo is Epithelial-to-Mesenchymal Transition (EMT) and its reverse Mesenchymal-to ...
Mohit Kumar eJolly, Marcelo eBoareto, Bin eHuang, Dongya eJia, Mingyang eLu, José N Onuchic, Herbert eLevine, Eshel eBen-Jacob   +7 more
doaj   +1 more source

Plasma Exosome Profiling of Cancer Patients by a Next Generation Systems Biology Approach

Scientific Reports, 2017
Technologies capable of characterizing the full breadth of cellular systems need to be able to measure millions of proteins, isoforms, and complexes simultaneously.
V. Domenyuk, Zhenyu Zhong, A. Stark, N. Xiao, Heather A. O'Neill, Xixi Wei, Jie Wang, Teresa T. Tinder, Sonal S. Tonapi, J. Duncan, T. Hornung, Andrew Hunter, M. Miglarese, J. Schorr, D. Halbert, John Quackenbush, G. Poste, D. Berry, G. Mayer, M. Famulok, D. Spetzler   +20 more
semanticscholar   +1 more source

Fruit Flies Provide New Insights in Low-Radiation Background Biology at the INFN Underground Gran Sasso National Laboratory (LNGS) [PDF]

, 2018
Deep underground laboratories (DULs) were originally created to host particle, astroparticle or nuclear physics experiments requiring a low-background environment with vastly reduced levels of cosmic-ray particle interference. More recently, the range of
Cenci, G., Cipressa, F, Esposito, G, Morciano, P, Porrazzo, A, Tabocchini, Ma   +5 more
core   +1 more source

Circulating histones as clinical biomarkers in critically ill conditions

FEBS Letters, EarlyView.
Circulating histones are emerging as promising biomarkers in critical illness due to their diagnostic, prognostic, and therapeutic potential. Detection methods such as ELISA and mass spectrometry provide reliable approaches for quantifying histone levels in plasma samples.
José Luis García‐Gimenez, Juan Carlos Ruiz‐Rodríguez, Ricard Ferrer, Raquel Durá, Antonio Artigas, Iván Bajaña, David Bolado López de Andujar, Irene Cánovas‐Cervera, Adrián Ceccato, Luis Chiscano‐Camón, Elena Climent‐Martinez, Georgia García Fernández, Gemma Goma, Verónica Monforte, Beatriz Quevedo‐Sánchez, Adolf Ruiz‐Sanmartín, Antonio Sierra‐Rivera, Nieves Carbonell Monleón   +17 more
wiley   +1 more source

Basal MET phosphorylation is an indicator of hepatocyte dysregulation in liver disease

Molecular Systems Biology
Chronic liver diseases are worldwide on the rise. Due to the rapidly increasing incidence, in particular in Western countries, metabolic dysfunction-associated steatotic liver disease (MASLD) is gaining importance as the disease can develop into ...
Sebastian Burbano de Lara, Svenja Kemmer, Ina Biermayer, Svenja Feiler, Artyom Vlasov, Lorenza A D’Alessandro, Barbara Helm, Christina Mölders, Yannik Dieter, Ahmed Ghallab, Jan G Hengstler, Christiane Körner, Madlen Matz-Soja, Christina Götz, Georg Damm, Katrin Hoffmann, Daniel Seehofer, Thomas Berg, Marcel Schilling, Jens Timmer, Ursula Klingmüller   +20 more
doaj   +1 more source

Can a systems approach produce a better understanding of mood disorders? [PDF]

, 2016
Background: One in twenty-five people suffer from a mood disorder. Current treatments are sub-optimal with poor patient response and uncertain modes-of-action.
Agren, Akiskal, AlGhamdi, Andreasen, Anguelova, Antelman, Arban, Archer, Badner, Ball, Barrett, Bauer, Bilder, Bramham, Bromet, Brown, Calabrese, Cappeliez, Castren, Choudhary, Cloninger, Corena-McLeod, Craddock, Craddock, Crick, Cruceanu, Czeisler, Dallmann, Davies, de la Grange, Detera-Wadleigh, Detera-Wadleigh, Ewald, Fiorentino, Franceschini, Frank, Funder, Garver, Gilman, Gonzalez, Gupta, Gupta, Hedman, Herberth, Higgins, Higgins, Holmans, Holsboer, Hopkins, Howald, Howe, Iwamoto, Jawahar, Jones, Kaelin, Kinney, Kirk, Kitano, Kitano, Kolodkin, Kolodkin, Kolodkin, Kripke, Kubota, Lander, Lee, Leibenluft, Leloup, Leoncikas, Levy, Lewy, Lim, Liu, Luuk, Maher, Mannisto, McInnis, Merikangas, Millard, Miller, Mitchell, Mitchell, Mitjans, Moller-Levet, Muller, Nanavati, Nestler, Neves-Pereira, Nick Plant, Oberlander, Olsen, Orth, Oswald, Plant, Plant, Plant, Popova, Preisig, Prickaerts, Richards, Roybal, Rubinow, Rubinsztein, Santosa, Scheper, Schildkraut, Schwartz, Segurado, Shlomi, Skibinska, Sklar, Sklar, Steinan, Stokkan, Suri, Takahashi, Terfve, Thompson, Toker, Turecki, Uehara, Uhlen, Vilar, Villasenor, Villen, Vucic, W.H. Organization, Walderhaug, Wang, Warburton, Weaver, Wehr, Wei, Westerhoff, Whybrow, Wishart, Woolf, Yeh, Yizhak, Yizhak, Ziats   +140 more
core   +1 more source

Single‐cell insights into the role of T cells in B‐cell malignancies

FEBS Letters, EarlyView.
Single‐cell technologies have transformed our understanding of T cell–tumor cell interactions in B‐cell malignancies, revealing new T‐cell subsets, functional states, and immune evasion mechanisms. This Review synthesizes these findings, highlighting the roles of T cells in pathogenesis, progression, and therapy response, and underscoring their ...
Laura Llaó‐Cid
wiley   +1 more source