Results 21 to 30 of about 13,309,360 (299)

Systems biology based drug repositioning for development of cancer therapy

, 2021
Drug repositioning is a powerful method that can assists the conventional drug discovery process by using existing drugs for treatment of a disease rather than its original indication.
Turanli, B., Turanli, Beste, Altay, O., Mardinoglu, A., Nielsen, Jens B, Nielsen, J., Turanli, Beste,, Uhlen, M, Mardinoglu, Adil,, Nielsen, J, Uhlen, Mathias,, Arga, Kazim Y., Bor\ue9n, Jan, Turkez, Hasan, Mardinoglu, Adil, Borén, J, Uhlen, Mathias, Uhlen, M., Turanli, B, Turkez, H., Arga, KY, Altay, Ozlem, Altay, Ozlem,, Arga, K. Y., Mardinoglu, A, Borén, Jan,, Arga, Kazim Y.,, Altay, O, Nielsen, Jens B,, Turkez, Hasan,   +29 more
core   +2 more sources

A network approach reveals driver genes associated with survival of patients with triple-negative breast cancer

iScience, 2021
Summary: We aimed to identify triple-negative breast cancer (TNBC) drivers that regulate survival time as predictive signatures that improve TNBC prognostication.
Courtney D. Dill, Eric B. Dammer, Ti'ara L. Griffen, Nicholas T. Seyfried, James W. Lillard, Jr.   +4 more
doaj   +1 more source

Tumor microenvironment mimicking 3D models unveil the multifaceted effects of SMAC mimetics

iScience, 2023
Summary: Small molecule IAP antagonists - SMAC mimetics (SM) - are being developed as an anticancer therapy. SM therapy was demonstrated not only to sensitize tumor cells to TNFα-mediated cell death but also to exert immunostimulatory properties.
Catarina Pinto, Ksenija Slavic-Obradovic, Daniela Fürweger, Barbara Thaler, Abdallah Souabni, Sebastian Carotta, Martin Aichinger, Ulrich Reiser, Maria Antonietta Impagnatiello, Iñigo Tirapu   +9 more
doaj   +1 more source

A systems biology view of cancer [PDF]

Biochimica et Biophysica Acta (BBA) - Reviews on Cancer, 2009
In order to understand how a cancer cell is functionally different from a normal cell it is necessary to assess the complex network of pathways involving gene regulation, signaling, and cell metabolism, and the alterations in its dynamics caused by the several different types of mutations leading to malignancy.
Laubenbacher, Reinhard, Hower, Valerie, Jarrah, Abdul, Torti, Suzy V., Shulaev, Vladimir, Mendes, Pedro, Torti, Frank M., Akman, Steven   +7 more
openaire   +2 more sources

Development of OX40 agonists for canine cancer immunotherapy

iScience, 2022
Summary: Recent breakthroughs in cancer immunotherapy have provided unprecedented clinical benefits to human cancer patients. Cancer is also one of the most common causes of death in pet dogs.
Damien Ruiz, Chloe Haynes, Jonathan Marable, Chetan Pundkar, Rebecca L. Nance, Deepa Bedi, Payal Agarwal, Amol S. Suryawanshi, Amarjit Mishra, Bruce F. Smith, Maninder Sandey   +10 more
doaj   +1 more source

Comparative assessment of genes driving cancer and somatic evolution in non-cancer tissues: an update of the Network of Cancer Genes (NCG) resource

Genome Biology, 2022
Background Genetic alterations of somatic cells can drive non-malignant clone formation and promote cancer initiation. However, the link between these processes remains unclear and hampers our understanding of tissue homeostasis and cancer development ...
Lisa Dressler, Michele Bortolomeazzi, Mohamed Reda Keddar, Hrvoje Misetic, Giulia Sartini, Amelia Acha-Sagredo, Lucia Montorsi, Neshika Wijewardhane, Dimitra Repana, Joel Nulsen, Jacki Goldman, Marc Pollitt, Patrick Davis, Amy Strange, Karen Ambrose, Francesca D. Ciccarelli   +15 more
doaj   +1 more source

Computational and systems biology of cancer [PDF]

Computational and Systems Oncology, 2020
Ever since the war on cancer was declared in 1971, there has been an explosion in our understanding of this diverse group of diseases. The application of molecular genetics and molecular biology technologies have enabled a deep understanding of the genetic, epigenetic, signaling cascades, survival pathways, and invasive mechanisms that underlie the ...
openaire   +1 more source

Pioneer factors in development and cancer

iScience, 2021
Summary: Transcription factors (TFs) are essential mediators of epigenetic regulation and modifiers of penetrance. Studies from the past decades have revealed a sub-class of TF that is capable of remodeling closed chromatin states through targeting ...
Benjamin D. Sunkel, Benjamin Z. Stanton
doaj   +1 more source

Systems Biology of Cancer Metastasis [PDF]

Cell Systems, 2019
Cancer metastasis is no longer viewed as a linear cascade of events but rather as a series of concurrent, partially overlapping processes, as successfully metastasizing cells assume new phenotypes while jettisoning older behaviors. The lack of a systemic understanding of this complex phenomenon has limited progress in developing treatments for ...
Yasir, Suhail, Margo P, Cain, Kiran, Vanaja, Paul A, Kurywchak, Andre, Levchenko, Raghu, Kalluri, , Kshitiz   +6 more
openaire   +2 more sources

Cellular and molecular effects of PNCK, a non-canonical kinase target in renal cell carcinoma

iScience, 2022
Summary: Renal cell carcinoma (RCC) is a fatal disease when advanced. While immunotherapy and tyrosine kinase inhibitor-based combinations are associated with improved survival, the majority of patients eventually succumb to the disease.
Derek J. Essegian, Valery Chavez, Floritza Bustamante, Stephan C. Schürer, Jaime R. Merchan   +4 more
doaj   +1 more source