Results 51 to 60 of about 13,309,360 (299)

SCLC TumorMiner: A genomics platform for small cell lung cancer precision oncology

iScience
Summary: Small cell lung cancer (SCLC) is among the most aggressive malignancies. Unlike many other cancers, it is not represented in The Cancer Genome Atlas, and available datasets are fragmented across institutions, disease stages, and treatment ...
Fathi Elloumi, Anjali Dhall, Daiki Taniyama, Augustin Luna, Yasuhiro Arakawa, Sudhir Varma, Yanghsin Wang, Anisha Tehim, Mark Raffeld, Kenneth Aldape, Christophe Redon, Roshan Shrestha, William Reinhold, Mirit Aladjem, Jaydira Del Rivero, Nitin Roper, Anish Thomas, Yves Pommier   +17 more
doaj   +1 more source

Mathematical modelling of cancer invasion : implications of cell adhesion variability for tumour infiltrative growth patterns [PDF]

, 2014
Cancer invasion, recognised as one of the hallmarks of cancer, is a complex, multiscale phenomenon involving many inter-related genetic, biochemical, cellular and tissue processes at different spatial and temporal scales.
Trucu, Dumitru; id_orcid, Chaplain, Mark A. J., Domschke, Pia, Trucu, Dumitru, Gerisch, Alf   +4 more
core   +1 more source

Systems Biology and the Integration of Mechanistic Explanation and Mathematical Explanation [PDF]

, 2013
The paper discusses how systems biology is working toward complex accounts that integrate explanation in terms of mechanisms and explanation by mathematical models—which some philosophers have viewed as rival models of explanation.
Brigandt, Ingo
core   +1 more source

So what do we really mean when we say that systems biology is holistic? [PDF]

, 2010
Background: An old debate has undergone a resurgence in systems biology: that of reductionism versus holism. At least 35 articles in the systems biology literature since 2003 have touched on this issue.
Gatherer, Derek
core   +5 more sources

Highly variable cancer subpopulations that exhibit enhanced transcriptome variability and metastatic fitness

Nature Communications, 2016
Phenotypic and genetic intra-tumor heterogeneity have an important role in cancer progression and therapeutic resistance. Here, the authors show that phenotypically variable tumor subpopulations exhibit higher metastatic potential and display enhanced ...
Alexander Nguyen, Mitsukuni Yoshida, Hani Goodarzi, Sohail F. Tavazoie   +3 more
doaj   +1 more source

Systems Biology of the Cancer Cell

Annual Review of Biomedical Engineering
Questions in cancer have engaged systems biologists for decades. During that time, the quantity of molecular data has exploded, but the need for abstractions, formal models, and simplifying insights has remained the same. This review brings together classic breakthroughs and recent findings in the field of cancer systems biology, focusing on cancer ...
Kevin A, Janes, Matthew J, Lazzara
openaire   +2 more sources

European Standard Clinical Practice Guideline and EXPeRT Recommendations for the Diagnosis and Management of Gastroenteropancreatic Neuroendocrine Neoplasms in Children and Adolescents

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Pediatric gastroenteropancreatic neuroendocrine neoplasms (GEP‐NENs) are extremely rare and clinically heterogeneous. Management has largely been extrapolated from adult practice. This European Standard Clinical Practice Guideline (ESCP), developed by the EXPeRT network in collaboration with adult NEN experts, provides (adult) evidence ...
Michaela Kuhlen, Calogero Virgone, Antje Redlich, Michael Abele, Ricardo Lopez‐Almaraz, Tal Ben‐Ami, Ewa Bien, Gianni Bisogno, Maja Mazic Cesen, Andrea Ferrari, Malgorzata A. Krawczyk, Yves Reguerre, Dominik T. Schneider, Ines B. Brecht, Charlotte Rigaud, Bilgehan Yalcin, Rainer Claus, Christian Vokuhl, Constantin Lapa, Jörg Fuchs, Segolene Hescot, Thomas Walter, Julien Hadoux, Daniel Orbach   +23 more
wiley   +1 more source

Systems biology and cancer: Promises and perils [PDF]

Progress in Biophysics and Molecular Biology, 2011
Systems biology uses systems of mathematical rules and formulas to study complex biological phenomena. In cancer research there are three distinct threads in systems biology research: modeling biology or biophysics with the goal of establishing plausibility or obtaining insights, modeling based on statistics, bioinformatics, and reverse engineering ...
Stuart G, Baker, Barnett S, Kramer
openaire   +2 more sources

Solid Pseudopapillary Neoplasm of the Pancreas in Children and Adolescents: Expert Recommendations

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Solid pseudopapillary neoplasm of the pancreas (SPN) is a rare low‐grade malignant exocrine pancreatic tumor, mostly discovered during the second decade of life in females, with a very good prognosis, provided microscopically complete surgical excision is achieved.
Sabine Irtan, Michael Abele, Calogero Virgone, Michaela Kuhlen, Ricardo Lopez‐Almarez, Tal Ben‐Ami, Ewa Bien, Maja Cesen, Malgorzata A. Krawczyk, Andrea Ferrari, Gianni Bisogno, Yves Reguerre, Dominik T. Schneider, Louise Galmiche, Jorg Fuchs, Sarah Braungart, Bilgehan Yalcin, Ines B. Brecht, Daniel Orbach   +18 more
wiley   +1 more source

applied-systems-biology/mcat: Mcat v1.0.0

, 2021
This is the first release of the MSOT cluster analysis toolkit (Mcat) as ImageJ plugin, accompanied by its user manual and example data. Installation If you don't have ImageJ/Fiji installed yet, you can get it from https://imagej.net/Fiji.
Applied Systems Biology, Bianca Hoffmann
core   +1 more source