Results 111 to 120 of about 1,564,848 (340)

Genomic landscape associated with potential response to anti-CTLA-4 treatment in cancers

Nature Communications, 2017
There is an urgent need to identify predictive markers for selecting responders to immunotherapy. Here, the authors describe a transcriptional predictor of immunotherapy response and assess it in genomic data from ~ 10,000 human tissues across 30 ...
Chan-Young Ock, Jun-Eul Hwang, Bhumsuk Keam, Sang-Bae Kim, Jae-Jun Shim, Hee-Jin Jang, Sarang Park, Bo Hwa Sohn, Minse Cha, Jaffer A. Ajani, Scott Kopetz, Keun-Wook Lee, Tae Min Kim, Dae Seog Heo, Ju-Seog Lee   +14 more
doaj   +1 more source

Cancer systems immunology

eLife, 2020
Tumor immunology is undergoing a renaissance due to the recent profound clinical successes of tumor immunotherapy. These advances have coincided with an exponential growth in the development of –omics technologies. Armed with these technologies and their
Nathan E. Reticker-Flynn, E. Engleman
semanticscholar   +1 more source

SV40: Cell transformation and tumorigenesis [PDF]

, 2009
The story of SV40-induced tumorigenesis and cellular transformation is intimately entwined with the development of modern molecular biology. Because SV40 and other viruses have small genomes and are relatively easy to manipulate in the laboratory, they ...
Aaronson, Abercrombie, Ahuja, Ali, Anderson, Ashkenazi, Bargonetti, Beachy, Berger, Black, Black, Black, Borger, Botchan, Bouck, Brinster, Brockman, Brugge, Butel, Carbon, Cavender, Chang, Chao, Chen, Chen, Chiang, Cho, Clark, Clayton, Colby, Cole, Cole, Conzen, Cosman, Danna, Dawe, DeAngelis, DeCaprio, Defendi, Dickmanns, Dyson, Earle, Earle, Eckner, Eddy, Ewen, Fei, Fiers, Figge, Frearson, Galanti, Gerber, Gershon, Gershon, Girardi, Gjoerup, Gluzman, Gluzman, Graessmann, Graessmann, Graham, Groupe, Hahn, Harlow, Hatanaka, Hein, Henry, Ishikawa, James M. Pipas, Jensen, Kalderon, Kalderon, Kalderon, Kalderon, Kasper, Kelly, Ketner, Khera, Khoury, Kierstead, Kim, Kim, Kimura, Kimura, Kirschstein, Kit, Kit, Kit, Koch, Koprowski, Koprowski, Lai, Lai, Lai, Land, Lane, Lanford, Lebowitz, Lee, Lewis, Lewis, Li, Lill, Lill, Lilyestrom, Linzer, Lo, Loeber, Lovett, Ludlow, Ludlow, Luo, Macpherson, Manfredi, Manos, Manos, Markovics, Martin, Martin, May, May, May, May, Mertz, Michalovitz, Montano, Montano, Morrow, Moyer, Noonan, Oda, Osborn, Ozanne, Pallas, Peden, Peden, Peden, Peden, Peden, Peden, Pipas, Pipas, Pipas, Ponten, Porcu, Poulin, Quartin, Rabson, Rabson, Rapp, Rathi, Reddy, Risser, Robb, Robb, Rothschild, Ruley, Rundell, Rushton, Sachsenmeier, Saenz Robles, Saenz-Robles, Sambrook, Sanford, Scott, Seif, Sell, Shein, Shenk, Shin, Shortle, Simin, Sleigh, Slinskey, Smith, Smith, Sompayrac, Soprano, Srinivasan, Srinivasan, Stinebaugh, Stoker, Stringer, Stubdal, Sullivan, Sullivan, Sweet, Symonds, Tack, Tanaka, Tegtmeyer, Tegtmeyer, Tegtmeyer, Temin, Tevethia, Tevethia, Tevethia, Tevethia, Tevethia, Thompson, Tjian, Todaro, Todaro, Todaro, Todaro, Todaro, Todaro, Vogel, Vogel, Vogt, Wang, Westphal, White, Wilson, Winocour, Winocour, Yaciuk, Yamaguchi, Zalvide, Zalvide, Zhu, Zhu   +221 more
core   +1 more source

Flow‐based immunomagnetic enrichment of circulating tumor cells from diagnostic leukapheresis product

Molecular Oncology, EarlyView.
The number of circulating tumor cells obtained from prostate cancer patients was increased approximately 5‐fold compared to regular CellSearch when processing 2 mL diagnostic leukapheresis material aliquots and increased by 44‐fold when processing 20 mL DLA aliquots using the flow enrichment target capture Halbach‐array.
Michiel Stevens, Anouk Mentink, Frank A. W. Coumans, Eshwari Dathathri, Khrystany T. Isebia, Jaco Kraan, Ronald de Wit, John W. M. Martens, Leon W. M. M. Terstappen   +8 more
wiley   +1 more source

The Chernobyl Tissue Bank - A Repository for Biomaterial and Data Used in Integrative and Systems Biology Modeling the Human Response to Radiation [PDF]

, 2012
The only unequivocal radiological effect of the Chernobyl accident on human health is the increase in thyroid cancer in those exposed in childhood or early adolescence.
Bethel, J, Butcher, S, Galpine, A, Krznaric, M, Thomas, G, Tomlinson, CD, Unger, K, Woodbridge, M   +7 more
core   +2 more sources

Unlocking the potential of tumor‐derived DNA in urine for cancer detection: methodological challenges and opportunities

Molecular Oncology, EarlyView.
Urine is a rich source of biomarkers for cancer detection. Tumor‐derived material is released into the bloodstream and transported to the urine. Urine can easily be collected from individuals, allowing non‐invasive cancer detection. This review discusses the rationale behind urine‐based cancer detection and its potential for cancer diagnostics ...
Birgit M. M. Wever, Renske D. M. Steenbergen   +1 more
wiley   +1 more source

Protein abundance of AKT and ERK pathway components governs cell type‐specific regulation of proliferation

Molecular Systems Biology, 2017
Signaling through the AKT and ERK pathways controls cell proliferation. However, the integrated regulation of this multistep process, involving signal processing, cell growth and cell cycle progression, is poorly understood.
Lorenz Adlung, Sandip Kar, Marie‐Christine Wagner, Bin She, Sajib Chakraborty, Jie Bao, Susen Lattermann, Melanie Boerries, Hauke Busch, Patrick Wuchter, Anthony D Ho, Jens Timmer, Marcel Schilling, Thomas Höfer, Ursula Klingmüller   +14 more
doaj   +1 more source

ORF Capture-Seq as a versatile method for targeted identification of full-length isoforms

Nature Communications, 2020
Most human protein-coding genes are expressed as multiple isoforms. Here the authors present ORF Capture-seq that uses cloned ORFs as probes to capture and sequence full length transcript sequences.
Gloria M. Sheynkman, Katharine S. Tuttle, Florent Laval, Elizabeth Tseng, Jason G. Underwood, Liang Yu, Da Dong, Melissa L. Smith, Robert Sebra, Luc Willems, Tong Hao, Michael A. Calderwood, David E. Hill, Marc Vidal   +13 more
doaj   +1 more source

Identification of functional and diverse circulating cancer‐associated fibroblasts in metastatic castration‐naïve prostate cancer patients

Molecular Oncology, EarlyView.
Cancer‐associated fibroblasts (CAFs) promote cancer growth, invasion (metastasis), and drug resistance. Here, we identified functional and diverse circulating CAFs (cCAFs) in patients with metastatic prostate cancer (mPCa). cCAFs were found in higher numbers and were functional and diverse in mPCa patients versus healthy individuals, suggesting their ...
Richell Booijink, Leon W. M. M. Terstappen, Eshwari Dathathri, Khrystany Isebia, Jaco Kraan, John Martens, Ruchi Bansal   +6 more
wiley   +1 more source

Rac1 drives intestinal stem cell proliferation and regeneration [PDF]

, 2013
Adult stem cells are responsible for maintaining the balance between cell proliferation and differentiation within self-renewing tissues. The molecular and cellular mechanisms mediating such balance are poorly understood.
Alessandro Scopelliti, Amcheslavsky, Ashton, Biteau, Brand, Buchon, Buchon, Choi, Cordero, el Marjou, Ellenbroek, Hochmuth, Ito, Jiang, Julia Cordero, Kevin Myant, Kitagishi, Marcos Vidal, Micchelli, Miyamoto, Myant, Ohlstein, Owen Sansom, Owusu-Ansah, Radtke, Sara Haque, Tothova, Tsatmali, Walmsley   +28 more
core   +1 more source