Results 111 to 120 of about 468,736 (292)

Protein abundance of AKT and ERK pathway components governs cell type‐specific regulation of proliferation

Molecular Systems Biology, 2017
Signaling through the AKT and ERK pathways controls cell proliferation. However, the integrated regulation of this multistep process, involving signal processing, cell growth and cell cycle progression, is poorly understood.
Lorenz Adlung, Sandip Kar, Marie‐Christine Wagner, Bin She, Sajib Chakraborty, Jie Bao, Susen Lattermann, Melanie Boerries, Hauke Busch, Patrick Wuchter, Anthony D Ho, Jens Timmer, Marcel Schilling, Thomas Höfer, Ursula Klingmüller   +14 more
doaj   +1 more source

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Navigating Multi-Scale Cancer Systems Biology Towards Model-Driven Clinical Oncology and Its Applications in Personalized Therapeutics. [PDF]

Front Oncol, 2021
Gondal MN, Chaudhary SU.
europepmc   +1 more source

Mixed‐class J‐domain protein scaffolds promote expanded aggregate handling and multivalent Hsp70 engagement during functional disaggregase assembly

FEBS Letters, EarlyView.
Protein aggregates threaten proteostasis and cell health. In human cells, Hsp70–J‐domain protein‐based disaggregases remove aggregates, but how they assemble remains unclear. Our biochemical findings show that DNAJA2‐ and DNAJB1‐containing disaggregase scaffolds enhance luciferase aggregate targeting, and that Hsp70 recruitment by both J‐domain ...
Anna Szlachcic, Nadinath B. Nillegoda
wiley   +1 more source

A systems biology design and implementation of novel bioinformatics software tools for high throughput gene expression analysis [PDF]

, 2009
This thesis was submitted for the degree of Doctor of Philosophy and awarded by Brunel University.Microarray technology has revolutionized the field of molecular biology by offering an efficient and cost effective platform for the simultaneous ...
Khan, Mohsin Amir Faiz
core  

Decoding the dynamic extracellular matrix in cancer—3D models and bioscaffolds rewire the rules of tumor progression

FEBS Letters, EarlyView.
Cancer progression is regulated by the dynamic matrix code of the tumor microenvironment, which influences cellular behavior and disease development. Importantly, matrix remodeling in three‐dimensional cancer models more accurately reflects in vivo conditions compared to conventional two‐dimensional systems.
Sylvia Mangani, Konstantinos Spanopoulos, Zoi Piperigkou, Nikos K. Karamanos   +3 more
wiley   +1 more source

TumorML: Concept and requirements of an in silico cancer modelling markup language [PDF]

, 2011
This paper describes the initial groundwork carried out as part of the European Commission funded Transatlantic Tumor Model Repositories project, to develop a new markup language for computational cancer modelling, TumorML.
Cooper, Jonathan, Steve McKeever, David Johnson, Jonathan Cooper, Johnson, David, McKeever, Steve   +5 more
core   +1 more source

Patient-specific cancer genes contribute to recurrently perturbed pathways and establish therapeutic vulnerabilities in esophageal adenocarcinoma

Nature Communications, 2019
Identifying driver genes in unstable, heterogenous tumour types can be challenging. Here, Mourikis, Benedetti, Foxall and colleagues present a machine learning algorithm to tackle this problem in esophageal adenocarcinoma.
Thanos P. Mourikis, Lorena Benedetti, Elizabeth Foxall, Damjan Temelkovski, Joel Nulsen, Juliane Perner, Matteo Cereda, Jesper Lagergren, Michael Howell, Christopher Yau, Rebecca C. Fitzgerald, Paola Scaffidi, The Oesophageal Cancer Clinical and Molecular Stratification (OCCAMS) Consortium, Francesca D. Ciccarelli   +13 more
doaj   +1 more source

Identification of a Shiga toxin A‐derived peptide internalized into Gb3 receptor‐bearing cells via interaction with the Shiga toxin B subunit

FEBS Letters, EarlyView.
The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi, João C. Encarnação, Valeria Napolitano, Grzegorz Dubin, Grzegorz Popowicz, Karl Andersson, U. Helena Danielson   +6 more
wiley   +1 more source

Dissecting regulated cell death states and transformation mechanisms in the evolutionary trajectory of 30 cancers

iScience
Summary: Cancer is a heterogeneous disease driven by dysregulated cell death, which influences tumor progression and treatment responses. It is important to construct a systematic landscape that characterizes the dysregulation of regulated cell death ...
Yunpeng Zhang, Qi Ou, Congxue Hu, Chuo Peng, Tengyue Li, Xiaozhi Huang, Kuan Yang, Liyuan Li, Xia Li, Yingqi Xu   +9 more
doaj   +1 more source