Results 41 to 50 of about 468,736 (292)

Curating the innate immunity interactome [PDF]

, 2010
peer-reviewedBackground: The innate immune response is the first line of defence against invading pathogens and is regulated by complex signalling and transcriptional networks.
Laird, Matthew R, Anastasia Sribnaia, Winsor, Geoffrey L., Lynn, David J, Giselle Ring, Foroushani, Amir K., Laird, Matthew R., Que, Jaimmie, Geoffrey L Winsor, Robert EW Hancock, Sribnaia, Anastasia, Hancock, Robert E.W., Ring, Giselle, Melissa Yau, Fiona SL Brinkman, Calvin Chan, Jaimmie Que, David J Lynn, Brinkman, Fiona S. L., Naseer, Misbah, Matthew R Laird, Yau, Melissa, Lo, Raymond, Raymond Lo, Chan, Calvin, Wee, Kathleen, Winsor, Geoffrey L, Breuer, Karin, Kathleen Wee, Amir K Foroushani, Hancock, R. E. W. (Robert E. W.), Brinkman, Fiona S., Misbah Naseer, Karin Breuer, Lynn, David J.   +34 more
core   +1 more source

Patient-Derived Xenografts to Study Cancer Metabolism: When Does X Mark the Spot? [PDF]

, 2023
A major goal of cancer research is to understand the requirements for cancer growth and progression that can be exploited to treat patients. Model systems reduce the complexity and heterogeneity of human cancers to explore therapeutic hypotheses, however,
Nabel, Christopher S, Vander Heiden, Matthew G   +1 more
core   +1 more source

Network-based prediction of protein interactions

Nature Communications, 2019
Computational protein-protein interaction (PPI) prediction has the potential to complement experimental efforts to map interactomes. Here, the authors show that proteins tend to interact if one is similar to the other’s partners and that PPI prediction ...
István A. Kovács, Katja Luck, Kerstin Spirohn, Yang Wang, Carl Pollis, Sadie Schlabach, Wenting Bian, Dae-Kyum Kim, Nishka Kishore, Tong Hao, Michael A. Calderwood, Marc Vidal, Albert-László Barabási   +12 more
doaj   +1 more source

B cell linker protein (BLNK) is a regulator of Met receptor signaling and trafficking in non-small cell lung cancer

iScience, 2022
Summary: Met is an oncogene aberrantly activated in multiple cancers. Therefore, to better understand Met biology and its role in disease we applied the Mammalian Membrane Two-Hybrid (MaMTH) to generate a targeted interactome map of its interactions with
Shivanthy Pathmanathan, Zhong Yao, Paula Coelho, Robert Valla, Luka Drecun, Caroline Benz, Jamie Snider, Punit Saraon, Ingrid Grozavu, Max Kotlyar, Igor Jurisica, Morag Park, Igor Stagljar   +12 more
doaj   +1 more source

So what do we really mean when we say that systems biology is holistic? [PDF]

, 2010
Background: An old debate has undergone a resurgence in systems biology: that of reductionism versus holism. At least 35 articles in the systems biology literature since 2003 have touched on this issue.
Gatherer, Derek, Derek Gatherer
core   +1 more source

Systems Biology and Cytokines Potential Role in Lung Cancer Immunotherapy Targeting Autophagic Axis [PDF]

, 2023
Lung cancer accounts for the highest number of deaths among men and women worldwide. Although extensive therapies, either alone or in conjunction with some specific drugs, continue to be the principal regimen for evolving lung cancer, significant ...
Riya Khilwani, Shailza Singh
core   +1 more source

Genetic association and single-cell transcriptome analyses reveal distinct features connecting autoimmunity with cancers

iScience, 2022
Summary: Autoimmune diseases (ADs) are at a significantly higher risk of cancers with unclear mechanism. By searching GWAS catalog database and Medline, susceptible genes for five common ADs, including systemic lupus erythematosus (SLE), rheumatoid ...
Shasha Li, Chenyang Lu, Yuan Zhang, Xiaolu Zhao, Kequan Lin, Xiufang Kong, David Fox, Lixiang Xue, Lichao Sun, Yi Liu, Fengbiao Mao   +10 more
doaj   +1 more source

A Boolean-based systems biology approach to predict novel genes associated with cancer: Application to colorectal cancer [PDF]

, 2011
Background\ud \ud Cancer has remarkable complexity at the molecular level, with multiple genes, proteins, pathways and regulatory interconnections being affected.
Shivashankar H Nagaraj, Nagaraj, Shivashankar H., Antonio Reverter, Reverter, Antonio   +3 more
core   +1 more source

Organicism and Reductionism in Cancer Research: Towards a Systemic Approach [PDF]

, 2007
In recent cancer research, strong and apparently conflicting epistemological stances have been advocated by different research teams in a mist of an ever-growing body of knowledge ignited by ever-more perplexing and non-conclusive experimental facts: in ...
Malaterre, Christophe, Christophe Malaterre   +1 more
core   +1 more source

Systems oncology : towards patient-specific treatment regimes informed by multiscale mathematical modelling [PDF]

, 2014
The multiscale complexity of cancer as a disease necessitates a corresponding multiscale modelling approach to produce truly predictive mathematical models capable of improving existing treatment protocols.
Gibin Powathil, Powathil, Gibin G., Chaplain, Mark A. J., Swat, Maciej   +3 more
core   +1 more source