Results 181 to 190 of about 1,583,856 (340)

Cell‐free DNA aneuploidy score as a dynamic early response marker in prostate cancer

Molecular Oncology, EarlyView.
mFast‐SeqS‐based genome‐wide aneuploidy scores are concordant with aneuploidy scores obtained by whole genome sequencing from tumor tissue and can predict response to ARSI treatment at baseline and, at an early time point, to ARSI and taxanes. This assay can be easily performed at low cost and requires little input of cfDNA. Cell‐free circulating tumor
Khrystany T. Isebia, Anouk C. de Jong, Lisanne F. van Dessel, Vanja de Weerd, Corine Beaufort, Jean Helmijr, José Alberto Nakauma‐González, Job van Riet, Paul Hamberg, Daniel Vis, Michiel S. van der Heijden, Nick Beije, Martijn P. Lolkema, Teoman Deger, Saskia M. Wilting, Ronald de Wit, Maurice P. H. M. Jansen, John W. M. Martens   +17 more
wiley   +1 more source

Biology of the gonadotropin-releasing hormone system in gynecological cancers

, 2002
Carsten Gründker, AR Gunthert, S Westphalen, Günter Emons   +3 more
openalex   +1 more source

ELECANS—an integrated model development environment for multiscale cancer systems biology [PDF]

, 2013
Safee Ullah Chaudhary, Sung‐Young Shin, Daewon Lee, Je-Hoon Song, Kwang‐Hyun Cho   +4 more
openalex   +1 more source

Integration of single‐cell and bulk RNA‐sequencing data reveals the prognostic potential of epithelial gene markers for prostate cancer

Molecular Oncology, EarlyView.
Prostate cancer is a leading malignancy with significant clinical heterogeneity in men. An 11‐gene signature derived from dysregulated epithelial cell markers effectively predicted biochemical recurrence‐free survival in patients who underwent radical surgery or radiotherapy.
Zhuofan Mou, Lorna W. Harries
wiley   +1 more source

Systems Biology for Understanding Cancer Biology [PDF]

Current Synthetic and Systems Biology, 2013
openaire   +1 more source

Clinical significance of stratifying prostate cancer patients through specific circulating genes

Molecular Oncology, EarlyView.
We tested a specific panel of genes representative of luminal, neuroendocrine and stem‐like cells in the blood of prostate cancer patients, showing predictive value from diagnosis to late stages of disease. This approach allows monitoring of treatment responses and outcomes at specific time points in trajectories.
Seta Derderian, Edouard Jarry, Arynne Santos, Quentin Vesval, Lucie Hamel, Rafael Sanchez‐Salas, Alexis Rompré‐Brodeur, Wassim Kassouf, Raghu Rajan, Fadi Brimo, Marie Duclos, Armen Aprikian, Simone Chevalier   +12 more
wiley   +1 more source

Rapid mechanical phenotyping of breast cancer cells based on stochastic intracellular fluctuations

iScience
Summary: Predicting the phenotypic impact of genetic variants and treatments is crucial in cancer genetics and precision oncology. Here, we have developed a noise decorrelation method that enables quantitative phase imaging (QPI) with the capability for ...
Álvaro Cano, Marina L. Yubero, Carmen Millá, Verónica Puerto-Belda, Jose J. Ruz, Priscila M. Kosaka, Montserrat Calleja, Marcos Malumbres, Javier Tamayo   +8 more
doaj  

Cancer In Silico Drug Discovery: A Systems Biology Tool for Identifying Candidate Drugs to Target Specific Molecular Tumor Subtypes [PDF]

, 2014
F. Anthony San Lucas, Jerry Fowler, Kyle Chang, Scott Kopetz, Eduardo Vilar, Paul Scheet   +5 more
openalex   +1 more source

MET variants with activating N‐lobe mutations identified in hereditary papillary renal cell carcinomas still require ligand stimulation

Molecular Oncology, EarlyView.
MET variants in the N‐lobe of the kinase domain, found in hereditary papillary renal cell carcinoma, require ligand stimulation to promote cell transformation, in contrast to other RTK variants. This suggests that HGF expression in the microenvironment is important for tumor growth in such patients. Their sensitivity to MET inhibitors opens the way for
Célia Guérin, Audrey Vinchent, Marie Fernandes, Isabelle Damour, Agathe Laratte, Rémi Tellier, Gabriella O. Estevam, Jean‐Pascal Meneboo, Céline Villenet, Clotilde Descarpentries, James S. Fraser, Martin Figeac, Alexis B. Cortot, Etienne Rouleau, David Tulasne   +14 more
wiley   +1 more source

Integrating Systems Biology and an Ex Vivo Human Tumor Model Elucidates PD-1 Blockade Response Dynamics

iScience, 2020
Summary: Ex vivo human tumor models have emerged as promising, yet complex tools to study cancer immunotherapy response dynamics. Here, we present a strategy that integrates empirical data from an ex vivo human system with computational models to ...
Munisha Smalley, Michelle Przedborski, Saravanan Thiyagarajan, Moriah Pellowe, Amit Verma, Nilesh Brijwani, Debika Datta, Misti Jain, Basavaraja U. Shanthappa, Vidushi Kapoor, Kodaganur S. Gopinath, D.C. Doval, K.S. Sabitha, Gaspar Taroncher-Oldenburg, Biswanath Majumder, Pradip Majumder, Mohammad Kohandel, Aaron Goldman   +17 more
doaj