Results 201 to 210 of about 479,650 (261)

Applications of synthetic biology in biomedicine. [PDF]

Mol Biomed
Li CX, Liu ZX, Lin YF, Wang ZH, Yang YM, Feng SY, Sun YH, Zhang XT, Fu W, Ding YF, Gao CC, Qin HY, Zhao JL.   +12 more
europepmc   +1 more source

Malformin A1–mediated cytotoxicity in ovarian cancer cells occurs through pyroptosis and autophagy

FEBS Open Bio, EarlyView.
This study investigated the effects of the natural compound Malformin A1 (MA1) on the cytoskeleton that regulates cell proliferation and migration. Disruption of the cytoskeleton can impair these processes and promote cancer cell death. MA1 disrupted cytoskeletal organization, induced DNA damage, inflammation, activated autophagy, and pyroptosis ...
Nada Abdullah Hassan, Ikram A. Burney, Shika Hanif Malgundkar, Siva Ramamoorthy, Ressin Varghese, Mohamed A. Al‐Kindi, Hamad Al Riyami, Shadia Al Bahlani, Sergey Dobretsov, Syed Imran Hassan, Benjamin K. Tsang, Yahya Tamimi   +11 more
wiley   +1 more source

Leveraging Microphysiological Systems to Facilitate Neutrophil-Based Cancer Immunotherapy. [PDF]

Adv Sci (Weinh)
Shao S, Diehl MI, Jones CN.
europepmc   +1 more source

Ionomycin suppresses cancer cell growth by disrupting mitochondrial transcription

FEBS Open Bio, EarlyView.
In this study, we identify a new function for the selective Ca2+ ionophore, ionomycin, as an inhibitor of mitochondrial transcription. Both total and nascent RNA analyses revealed that ionomycin treatment reduces the transcription of mitochondrial genes.
Lishen Wang, Mingqiang Deng, Dongmei He, Diqin Lai, Dongjun Liu, Dengyong Zhu, Zhenhua Zhang, Peng Tang, Chuanman Zhou, Menghui Yin, Xichen Bao   +10 more
wiley   +1 more source

Dose‐dependent hepatotoxicity of hydrogen peroxide in HepG2 cells and its modulation by CYP450 induction

FEBS Open Bio, EarlyView.
NMR metabolomics revealed concentration‐dependent metabolic perturbations in HepG2 cells exposed to H2O2. Rifampicin pretreatment enhanced metabolic competence, attenuated toxin‐induced alterations and produced metabolite profiles more consistent with human liver physiology, supporting the use of CYP450‐induced HepG2 models for improved in vitro ...
Maren Jinks, Garth L. Maker, Emily C. Davies, Berin A. Boughton, Samantha Lodge   +4 more
wiley   +1 more source

Beyond treatment eligibility: rethinking theranostic targets. [PDF]

Front Oncol
Montemagno C, Serrano B, Paulmier B.
europepmc   +1 more source

Skin Health Literacy in Ontario Secondary Schools: An Overlooked Opportunity for Preventive Health Education. [PDF]

J Sch Health
Podobnik J.
europepmc   +1 more source

Corrigendum to 'Health networking on cancer in the European Union: a 'green paper' by the EU Joint Action on Networks of Expertise (JANE)': [ESMO Open. Volume 10, Issue 2, February 2025, 104126]. [PDF]

ESMO Open
Casali PG, Antoine-Poirel H, Berrocoso S, Blay JY, Dubois T, Ferrari A, Fullaondo A, Hovig E, Jagodzińska-Mucha P, Ługowska I, Kaasa S, Nicoară D, Pletsa V, Provenzano S, Santoro M, Šekerija M, Van Hoof W, Vyas M, Trama A, JANE Consortium.   +19 more
europepmc   +1 more source

Special Issue "Bioinformatics of Gene Regulations and Structure-2025". [PDF]

Int J Mol Sci
Orlov YL, Anashkina AA, Minenko IA, Kolchanov NA.   +3 more
europepmc   +1 more source

Bridging BET bromodomain and immune checkpoint inhibitors through generative bioorganic frameworks for next-generation cancer immunotherapy. [PDF]

RSC Med Chem
Diab MK, Yassen ASA, Fahmy SA, Ashour HF, Nafie MS.   +4 more
europepmc   +1 more source