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2010
Cancer is a complex and heterogeneous disease, not only at a genetic and biochemical level, but also at a tissue, organism, and population level. Multiple data streams, from reductionist biochemistry in vitro to high-throughput "-omics" from clinical material, have been generated with the hope that they encode useful information about phenotype and ...
Dana, Faratian +4 more
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Cancer is a complex and heterogeneous disease, not only at a genetic and biochemical level, but also at a tissue, organism, and population level. Multiple data streams, from reductionist biochemistry in vitro to high-throughput "-omics" from clinical material, have been generated with the hope that they encode useful information about phenotype and ...
Dana, Faratian +4 more
+5 more sources
Current Opinion in Oncology, 2005
Significant insight can be gained into complex biologic mechanisms of cancer via a combined computational and experimental systems biology approach. This review highlights some of the major systems biology efforts that were applied to cancer in the past year.Two main approaches to computational systems biology are discussed: mechanistic dynamical ...
I G, Khalil, C, Hill
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Significant insight can be gained into complex biologic mechanisms of cancer via a combined computational and experimental systems biology approach. This review highlights some of the major systems biology efforts that were applied to cancer in the past year.Two main approaches to computational systems biology are discussed: mechanistic dynamical ...
I G, Khalil, C, Hill
openaire +2 more sources
Cancer: A Systems Biology disease
Biosystems, 2006Cancer research has focused on the identification of molecular differences between cancerous and healthy cells. The emerging picture is overwhelmingly complex. Molecules out of many parallel signal transduction pathways are involved. Their activities appear to be controlled by multiple factors.
Hornberg, J.J. +3 more
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Systems Biology and the Molecular Circuits of Cancer
ChemBioChem, 2004AbstractProliferative disorders are a major challenge for human health. The understanding of the organization of cell‐cycle events is of the utmost importance to devise effective therapeutic strategies for cancer. The awareness that cells and organisms are complex, modular, hierarchical systems and the availability of genome‐wide gene expression and ...
ALBERGHINA, LILIA +2 more
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