Results 211 to 220 of about 1,583,856 (340)

Bioscore: A Staging System for Breast Cancer Patients that Reflects the Prognostic Significance of Underlying Tumor Biology [PDF]

, 2017
Elizabeth A. Mittendorf, Mariana Chávez‐MacGregor, José Vila, Min Yi, Daphne Y. Lichtensztajn, Christina A. Clarke, Sharon H. Giordano, Kelly K. Hunt   +7 more
openalex   +1 more source

Metabolic Reprogramming of Fibroblasts as Therapeutic Target in Rheumatoid Arthritis and Cancer: Deciphering Key Mechanisms Using Computational Systems Biology Approaches [PDF]

, 2020
Sahar Aghakhani, Naouel Zerrouk, Anna Niarakis   +2 more
openalex   +1 more source

Supplementary Table 6 from A Systems Biology Approach Identifies SART1 as a Novel Determinant of Both 5-Fluorouracil and SN38 Drug Resistance in Colorectal Cancer [PDF]

, 2023
Wendy L. Allen, Leanne Stevenson, Vicky M. Coyle, Puthen V. Jithesh, Irina Proutski, Gail Carson, Melita A. Gordon, Heinz-Josef D. Lenz, Sandra Van Schaeybroeck, Daniel B. Longley, Patrick G. Johnston   +10 more
openalex   +1 more source

Peripheral blood proteome biomarkers distinguish immunosuppressive features of cancer progression

Molecular Oncology, EarlyView.
Immune status significantly influences cancer progression. This study used plasma proteomics to analyze benign 67NR and malignant 4T1 breast tumor models at early and late tumor stages. Immune‐related proteins–osteopontin (Spp1), lactotransferrin (Ltf), calreticulin (Calr) and peroxiredoxin 2 (Prdx2)–were associated with systemic myeloid‐derived ...
Yeon Ji Park, Jae Won Oh, Hyewon Chung, Jung Won Kwon, Yi Rang Na, Kwang Pyo Kim, Seung Hyeok Seok   +6 more
wiley   +1 more source

Editorial: Systems Biology and the Challenge of Deciphering the Metabolic Mechanisms Underlying Cancer [PDF]

, 2017
Osbaldo Resendis‐Antonio, Christian Diener   +1 more
openalex   +1 more source

Stochastic variation in the FOXM1 transcription program mediates replication stress tolerance

Molecular Oncology, EarlyView.
Cellular heterogeneity is a major cause of drug resistance in cancer. Segeren et al. used single‐cell transcriptomics to investigate gene expression events that correlate with sensitivity to the DNA‐damaging drugs gemcitabine and prexasertib. They show that dampened expression of transcription factor FOXM1 and its target genes protected cells against ...
Hendrika A. Segeren, Kathryn A. Wierenga, Frank M. Riemers, Elsbeth A. van Liere, Bart Westendorp   +4 more
wiley   +1 more source

Conditional robustness analysis for fragility discovery and target identification in biochemical networks and in cancer systems biology. [PDF]

BMC Syst Biol, 2015
Bianconi F, Baldelli E, Ludovini V, Petricoin EF, Crinò L, Valigi P.   +5 more
europepmc   +1 more source

Genome wide meta-analysis of cDNA datasets reveals new target gene signatures of colorectal cancer based on systems biology approach [PDF]

, 2020
Umair Ilyas, Shahiq uz Zaman, Reem Altaf, Humaira Nadeem, Syed Aun Muhammad   +4 more
openalex   +1 more source

Supplementary Methods from Systems Biology Reveals New Strategies for Personalizing Cancer Medicine and Confirms the Role of PTEN in Resistance to Trastuzumab [PDF]

, 2023
Dana Faratian, Alexey Goltsov, Галина Лебедева, Anatoly Sorokin, Stuart Moodie, Peter Mullen, Charlene Kay, In Hwa Um, Simon P. Langdon, Igor Goryanin, David J. Harrison   +10 more
openalex   +1 more source

Targeting PRAME directly or via EZH2 inhibition overcomes retinoid resistance and represents a novel therapy for keratinocyte carcinoma

Molecular Oncology, EarlyView.
The study evaluated the function and therapeutic implications of PRAME in basal cell carcinoma (BCC) and squamous cell carcinoma (SCC). The findings demonstrate that PRAME impairs keratinocyte differentiation pathways. Furthermore, PRAME impairs anticancer response to retinoid compounds in BCC and SCC cells.
Brandon Ramchatesingh, Amelia Martinez Villarreal, Philippe Lefrançois, Jennifer Gantchev, Sriraam Sivachandran, Samy Abou Setah, Ivan V. Litvinov   +6 more
wiley   +1 more source