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Cancer: A Systems Biology disease
Biosystems, 2006 Cancer research has focused on the identification of molecular differences between cancerous and healthy cells. The emerging picture is overwhelmingly complex. Molecules out of many parallel signal transduction pathways are involved. Their activities appear to be controlled by multiple factors.
Hornberg, J.J. +3 more
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Systems biology of cancer biomarker detection
Cancer Biomarkers, 2013 Cancer systems-biology is an ever-growing area of research due to explosion of data; how to mine these data and extract useful information is the problem. To have an insight on carcinogenesis one need to systematically mine several resources, such as databases, microarray and next-generation sequences. This review encompasses management and analysis of
Sanga, Mitra +2 more
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Systems Biology Applied to Cancer Research
, 2009 Complex diseases such as cancer have multiple origins and are therefore difficult to understand and cure. Highly parallel technologies such as DNA microarrays are now available. These provide a data deluge which needs to be mined for relevant information and integrated to existing knowledge at different scales.
Seigneuric, Renaud +6 more
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Cancer systems biology and modeling: Microscopic scale and multiscale approaches
Seminars in Cancer Biology, 2015 Cancer has become known as a complex and systematic disease on macroscopic, mesoscopic and microscopic scales. Systems biology employs state-of-the-art computational theories and high-throughput experimental data to model and simulate complex biological ...
Ali Masoudi-Nejad +2 more
exaly +2 more sources
A Roadmap of Cancer Systems Biology
Nature Precedings, 2010 What is cancer systems biology? Why should we conduct systems biology research in cancer? What is the relationships between systems biology and personalized medicine? How do we conduct cancer systems biology research?
Edwin Wang, Wang Edwin
exaly +5 more sources
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2010
Cancer is a complex and heterogeneous disease, not only at a genetic and biochemical level, but also at a tissue, organism, and population level. Multiple data streams, from reductionist biochemistry in vitro to high-throughput "-omics" from clinical material, have been generated with the hope that they encode useful information about phenotype and ...
Dana, Faratian +4 more
+5 more sources
Cancer is a complex and heterogeneous disease, not only at a genetic and biochemical level, but also at a tissue, organism, and population level. Multiple data streams, from reductionist biochemistry in vitro to high-throughput "-omics" from clinical material, have been generated with the hope that they encode useful information about phenotype and ...
Dana, Faratian +4 more
+5 more sources
Current Opinion in Oncology, 2005
Significant insight can be gained into complex biologic mechanisms of cancer via a combined computational and experimental systems biology approach. This review highlights some of the major systems biology efforts that were applied to cancer in the past year.Two main approaches to computational systems biology are discussed: mechanistic dynamical ...
I G, Khalil, C, Hill
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Significant insight can be gained into complex biologic mechanisms of cancer via a combined computational and experimental systems biology approach. This review highlights some of the major systems biology efforts that were applied to cancer in the past year.Two main approaches to computational systems biology are discussed: mechanistic dynamical ...
I G, Khalil, C, Hill
openaire +2 more sources