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Introduction: Cancer Systems and Integrative Biology
2023The insights provided by the holistic approaches of systems and integrative biology offer a means to address the multiple levels of complexity evident in cancer biology. Often focused on the use of large-scale, high-dimensional omics data for discovery in silico, integration with lower-dimensional data and lower-throughput wet laboratory studies allows
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Systems biology of cancer biomarker detection
Cancer Biomarkers, 2013Cancer systems-biology is an ever-growing area of research due to explosion of data; how to mine these data and extract useful information is the problem. To have an insight on carcinogenesis one need to systematically mine several resources, such as databases, microarray and next-generation sequences. This review encompasses management and analysis of
Sanga, Mitra +2 more
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Systems Biology Approaches in Cancer Pathology
2018The complex network of the tissue system, in both pre-neoplastic tissues and tumors, demonstrates the need for a systems biology approach to cancer pathology, in which quantification of key tissue system processes is combined with informatics tools to produce actionable scores to aid clinical decision-making.
Aaron, DeWard +1 more
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Abstract In contrast to prevailing wisdom that cancer is a genetic disease that evolves via Darwinian selection, it is increasingly recognized that in addition to genetic mutations, intratumoral heterogeneity also results through non-genetic mechanisms.
Ravi Salgia +3 more
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Ravi Salgia +3 more
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Systems Biology Applied to Cancer Research
2009Complex diseases such as cancer have multiple origins and are therefore difficult to understand and cure. Highly parallel technologies such as DNA microarrays are now available. These provide a data deluge which needs to be mined for relevant information and integrated to existing knowledge at different scales.
Seigneuric, Renaud +6 more
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Medecine sciences : M/S, 2010
Cancer Systems Biology is now accepted and recognized as a promising field both in biological and clinical research. It relies on a rigorous formalization of regulation networks into precise and unambiguous languages. It provides both detailed and modular views of the complex biological system of interest (which in cancer research is typically an ...
Emmanuel, Barillot +2 more
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Cancer Systems Biology is now accepted and recognized as a promising field both in biological and clinical research. It relies on a rigorous formalization of regulation networks into precise and unambiguous languages. It provides both detailed and modular views of the complex biological system of interest (which in cancer research is typically an ...
Emmanuel, Barillot +2 more
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Bioinformatics and Systems Biology of Cancers
2010Molecular databases and bioinformatics methods and tools are essential for modern cancer research. Multilevel analyses of all the protein-coding genes, thousands of proteins, and hundreds of metabolites require integration in terms of signaling and metabolic pathways and networks.
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