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Surgical Oncology Clinics of North America, 1998
Developments in molecular genetics, immunology, molecular and cellular biology, and tumor biology have given rise to the field of cancer gene therapy. Several gene delivery vehicles have been developed and are being examined in clinical trials. Most cancer gene therapy strategies involve introduction of genes to augment existing therapies.
J C, Cusack, K K, Tanabe
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Developments in molecular genetics, immunology, molecular and cellular biology, and tumor biology have given rise to the field of cancer gene therapy. Several gene delivery vehicles have been developed and are being examined in clinical trials. Most cancer gene therapy strategies involve introduction of genes to augment existing therapies.
J C, Cusack, K K, Tanabe
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Emerging role of exosomes in cancer therapy: progress and challenges
Molecular CancerThis review highlights recent progress in exosome-based drug delivery for cancer therapy, covering exosome biogenesis, cargo selection mechanisms, and their application across multiple cancer types.
Jiale Li, Jiachong Wang, Zigui Chen
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Glycoconjugates in Cancer Therapy
Anti-Cancer Agents in Medicinal Chemistry, 2008This review focuses on recent efforts in glycoconjugate construction for the creation and evaluation of vaccines based on carbohydrate cancer-associated antigens. This therapeutic approach takes advantage from the known tendency of transformed cells to express selective carbohydrate motifs otherwise hidden in normal cells. The immunological response is
CIPOLLA, LAURA FRANCESCA +2 more
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Glycosaminoglycans in cancer therapy
American Journal of Physiology-Cell Physiology, 2022Glycosaminoglycans (GAGs) are an important component of the tumor microenvironment (TME). GAGs can interact with a variety of binding partners and thereby influence cancer progression on multiple levels. GAGs can modulate growth factors and chemokine signaling, invasion, and metastasis formation. Moreover, GAGs are able to change the physical property
Ronja Wieboldt, Heinz Läubli
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2023
Abstract Heart failure can be caused by a range of cardiotoxic cancer therapies. The most common are anthracycline chemotherapy and human epidermal growth factor receptor 2 (HER2)-targeted therapies. However, with the development of targeted molecular cancer therapies, the number of cancer treatments causing heart failure are increasing ...
Dimitrios Farmakis +3 more
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Abstract Heart failure can be caused by a range of cardiotoxic cancer therapies. The most common are anthracycline chemotherapy and human epidermal growth factor receptor 2 (HER2)-targeted therapies. However, with the development of targeted molecular cancer therapies, the number of cancer treatments causing heart failure are increasing ...
Dimitrios Farmakis +3 more
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Cancer therapy with antibodies
Nature Reviews. CancerThe greatest challenge in cancer therapy is to eradicate cancer cells with minimal damage to normal cells. Targeted therapy has been developed to meet that challenge, showing a substantially increased therapeutic index compared with conventional cancer ...
Suman Paul +9 more
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Apoptosis, cancer and cancer therapy
Surgical Oncology, 1997Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis. Apoptosis is essential in the homeostasis of normal tissues of the body, especially those of the gastrointestinal tract, immune system and ...
R J, Bold, P M, Termuhlen, D J, McConkey
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MEK in cancer and cancer therapy
Pharmacology & Therapeutics, 2014The mitogen-activated extracellular signal-regulated kinase (MEK) pathway is one of the best-characterized kinase cascades in cancer cell biology. It is triggered by either growth factors or activating mutations of major oncogenic proteins in this pathway, the most common being Ras and Raf.
Cindy, Neuzillet +5 more
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The microbiome, cancer, and cancer therapy
Nature Medicine, 2019With the advent of next-generation sequencing, we have an unprecedented ability to study tumor and host genomes as well as those of the vast array of microorganisms that exist within living organisms. Evidence now suggests that these microbes may confer susceptibility to certain cancers and may also influence response to therapeutics.
Beth A, Helmink +4 more
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Cancer Letters, 2007
Several groups have reported in recent years that members of the plant stress hormones family of jasmonates, and some of their synthetic derivatives, exhibit anti-cancer activity in vitro and in vivo. Jasmonates increased the life span of EL-4 lymphoma-bearing mice, and exhibited selective cytotoxicity towards cancer cells while sparing normal blood ...
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Several groups have reported in recent years that members of the plant stress hormones family of jasmonates, and some of their synthetic derivatives, exhibit anti-cancer activity in vitro and in vivo. Jasmonates increased the life span of EL-4 lymphoma-bearing mice, and exhibited selective cytotoxicity towards cancer cells while sparing normal blood ...
openaire +2 more sources