Results 101 to 110 of about 198,762 (311)

Mechanism‐Informed Machine Learning Enables Discovery of Oncolytic Peptides for Cancer Immunotherapy

Advanced Science, EarlyView.
MISPOP integrates ensemble learning with membrane‐active physicochemical priors to identify Dermaseptin‐S9, a natural oncolytic peptide that disrupts tumor membranes, triggers immunogenic cell death, and shows strong antitumor activity. The study illustrates a mechanism‐informed route from peptide sequence data to cancer immunotherapy leads.
Wen Zhang, Shengxin Lu, Guangyong Zheng, Shensuo Li, Hongyu Chen, Mei Hong, Xiangru Zhou, Ruotian Tang, Ye Wu, Weidong Zhang, Dong Lu, Xin Luan   +11 more
wiley   +1 more source

Enhanced and sustained biodistribution of HIV-1 neutralizing antibody VRC01LS in human genital and rectal mucosa

Nature Communications
To prevent sexually-acquired HIV-1 infection by immunoprophylaxis, effective concentrations of broadly neutralizing antibodies are likely needed at mucosal sites of exposure.
Maria P. Lemos, Rena D. Astronomo, Yunda Huang, Sandeep Narpala, Madhu Prabhakaran, Philipp Mann, Carmen A. Paez, Yiwen Lu, Gregory J. Mize, Hayley Glantz, Katharine Westerberg, Hunter Colegrove, Kimberly S. Smythe, Minggang Lin, Robert H. Pierce, Julia Hutter, Ian Frank, John R. Mascola, Adrian B. McDermott, Linda-Gail Bekker, M. Juliana McElrath   +20 more
doaj   +1 more source

Development of Virus-infected Cancer Cell Vaccine [PDF]

, 2017
This project was financially supported by the research fund of the ENT Department at Barts Health NHS Trust and a Project Development Award by Barts Cancer Institute.This project was financially supported by the research fund of the ENT Department at ...
AL YAGHCHI, C
core  

Investigation of factors influencing the immunogenicity of hCG as a potential cancer vaccine [PDF]

, 2018
Human chorionic gonadotrophin (hCG) and its β‐subunit (hCGβ) are tumour autocrine growth factors whose presence in the serum of cancer patients has been linked to poorer prognosis.
Justesen, J., N Chikadze, Roitt, I.M., F A Hills, Martensen, P., J Makinde, Lund, T., J D McBride, J Justesen, Kvirkvelia, N., P J Delves, T Lund, I M Roitt, P M Martensen, N Kvirkvelia, Chikadze, N., N Porakishvili, Delves, P.J., Porakishvili, N.   +18 more
core   +1 more source

A Plug‐and‐Play Platform for Customizing Multivalent Degraders and Degrader‐Drug Conjugates

Advanced Science, EarlyView.
Membrane proteins remain challenging targets for conventional TPD approaches. Here, the authors develop UPTAB, a modular platform leveraging ultrahigh‐affinity orthogonal Im/CL protein pairs for lysosomal degradation of membrane proteins. Mono‐targeted (Type‐I), dual‐targeted (Type‐II), and tri‐targeted (Type‐III) UPTABs enable simultaneous degradation
Mengqing Zhao, Yan Deng, Jianjian Han, Yong Xie, Kai Bao, Lixin Ma, Lilong Liu, Wuxiang Mao   +7 more
wiley   +1 more source

Remission-Stage Ovarian Cancer Cell Vaccine with Cowpea Mosaic Virus Adjuvant Prevents Tumor Growth

, 2021
Ovarian cancer is the deadliest gynecological malignancy. Though most patients enter remission following initial interventions, relapse is common and often fatal. Accordingly, there is a substantial need for ovarian cancer therapies that prevent relapse.
Jennifer Fields, Gregory Ho, Nicole F. Steinmetz, Steven Fiering, Chenkai Mao, Veronique Beiss, Courtney T. Stump, Frank A. Veliz   +7 more
core   +1 more source

Reprogramming the Immune Landscape of Inflammatory Breast Cancer

Advanced Science, EarlyView.
Inflammatory breast cancer is the most lethal subtype of breast cancer and is characterized by an immunosuppressive tumor microenvironment (TME) driven by a complex network of immune cells and inflammatory cytokines, contributing to its aggressiveness and treatment challenges. Immune checkpoint inhibitors, either alone or in combination, show potential
Verena Martinez‐Rodriguez, Suguru Ogata, Xiaoping Wang, Naoto T. Ueno   +3 more
wiley   +1 more source

Socioeconomic inequalities in completion of hepatitis B vaccine series among Korean women: results from a nationwide interview survey

, 2012
BACKGROUND: Hepatitis B virus (HBV) infection and its sequelae are major global health problems. This study was conducted to investigate the association between factors related to socioeconomic status and HBV vaccination in the general population of ...
박은철
core  

Senescent Cell Derived Artificial Vesicle‐Based Senolytic Sonovaccine Platform with Augmented Lymph Node Delivery and Antigen Cross‐Presentation Efficacy

Advanced Science, EarlyView.
A senolytic sonovaccine platform (SenoVac) is developed, in which senescent cell‐derived vesicles serve as broad senescent cell antigen reservior. The “2‐step” click chemistry strategy for effective lymph node delivery, and ultrasound‐triggered endosomal escape to boost cross‐presentation, ensures efficient senescent cell clearance and disease ...
Liang Zhang, Yubo Lai, Jia Wang, Lingling Liu, Jieyuan An, Mi Qu, Yuan Liang, Bijun Tan, Guodong Yang, Xuekang Yang, Lijun Yuan   +10 more
wiley   +1 more source

Rational design of HIV vaccine and microbicides: report of the EUROPRISE annual conference. [PDF]

, 2010
EUROPRISE is a Network of Excellence sponsored from 2007 to 2011 by the European Commission within the 6th Framework Program. The Network encompasses a wide portfolio of activities ranging from an integrated research program in the field of HIV vaccines ...
Palma, Paolo, Palma Paolo, Lara Mainetti, Paolo Palma, Grupping, K., Reudelsterz, M., Robin Shattock, Hannes Uchtenhagen, Gabriella Scarlatti, Hallengärd, D, Uchtenhagen, H, Hallengärd David, Shattock Robin, Caroline Weber, Mainetti, Lara, Wahren, Britta, Winni De Haes, Coleman, A., Annette Sköld, Seifried, Janna, Sköld, A, Sköld Annette, Scarlatti, G, Lund University., Selhorst, P., Hornig Julia, van Gils, M. J., De Haes, W., Hornig, Julia, De Haes, W, Klein, K., Seifried Janna, Biswas, P., Da Costa, K., Da Costa Kelly, Da Costa, K, De Haes, Winni, Dieltjens Tessa, Wahren, B., Reudelsterz, Marc, Palma, P., Borggren, Marie,, Dispinseri Stefania, Seifried, J., Uchtenhagen, Hannes, Hornig, J., Borggren, Marie, Da Costa, Kelly, Scarlatti Gabriella, Selhorst, P, Wahren, B, Selhorst Philippe, David Hallengärd, Kelly Da Costa, Katrijn Grupping, Priscilla Biswas, Shattock, R., Katja Klein, Mainetti Lara, Mainetti, L., Janna Seifried, Dieltjens, Tessa, Scarlatti, Gabriella, Klein Katja, Marit J van Gils, Weber, Caroline, Weber, C, De Haes Winni, Uchtenhagen Hannes, Grupping Katrijn, van Gils, M.J., Borggren Marie, Adam Coleman, Weber Caroline, Shattock, R, Hornig, J, van Gils Marit J, Marie Borggren, Borggren, M, Selhorst, Philippe, Costa, Kelly Da, Mainetti, L, Skold, A., Biswas, P, Coleman, Adam, Coleman, A, Stefania Dispinseri, Gils, Marit J. van, Palma, P, Wahren Britta, Marc Reudelsterz, Hallengard, David, Seifried, J, Haes, Winni De, van Gils, MJ, Weber, C., Scarlatti, G., Philippe Selhorst, Biswas Priscilla, Reudelsterz, M, van Gils, Marit J., Klein, K, Hallengard, D., Britta Wahren, Tessa Dieltjens, Borggren, M., Dieltjens, T., Coleman Adam, Grupping, K, Biswas, Priscilla, Skold, Annette, Grupping, Katrijn, Dispinseri, S., Dieltjens, T, Dispinseri, S, Klein, Katja, Reudelsterz Marc, Julia Hornig, Dispinseri, Stefania, Shattock, Robin   +119 more
core   +1 more source