Results 91 to 100 of about 198,762 (311)

Adolescent BCG revaccination induces a phenotypic shift in CD4+ T cell responses to Mycobacterium tuberculosis

Nature Communications
A recent clinical trial demonstrated that Bacille Calmette-Guérin (BCG) revaccination of adolescents reduced the risk of sustained infection with Mycobacterium tuberculosis (M.tb).
One B. Dintwe, Lamar Ballweber Fleming, Valentin Voillet, John McNevin, Aaron Seese, Anneta Naidoo, Saleha Omarjee, Linda-Gail Bekker, James G. Kublin, Stephen C. De Rosa, Evan W. Newell, Andrew Fiore-Gartland, Erica Andersen-Nissen, M. Juliana McElrath   +13 more
doaj   +1 more source

Development of prostrate cancer vaccine using PAP as target antigen

, 2014
Treatment options for patients with advanced prostate cancer (PC) still remain limited and rarely curative. The prostatic acid phosphatase (PAP) is prostate specific protein over-expressed in more than 90% of prostate tumours.
Javad, JMS
core  

Physicians’ attitudes towards human papillomavirus vaccination programme: A systematic review [PDF]

, 2011
Human papillomavirus (HPV) vaccine is a newly introduced vaccine against cervical cancer in adolescent girls. Uptake of the vaccine will be dependent on parental acceptability and physician recommendation.
Franco, Maria F.
core  

Economic evaluation of three populational screening strategies for cervical cancer in the county of Valles Occidental: CRICERVA clinical trial [PDF]

, 2011
Copyright @ 2011 Acera et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution ...
Bonet, JM, Trapero-Bertran, Marta, Pilar Soteras, Sanchez, Norman, Sanchez, N, Soteras, P, Prieto, Gemma, Rodriguez, A, Gemma Prieto, Hidalgo Pablo, Soteras Pilar, Prieto Gemma, Josep M Bonet, Manresa Josep M, Bonet Josep M, Rodriguez Ana, Hidalgo, Pablo, Toran Pere, Trapero-Bertran, M, Sanchez Norman, Marta Trapero-Bertran, Acera Amelia, Norman Sanchez, Josep M Manresa, Toran, P, Pere Toran, Manresa, Josep M., Pablo Hidalgo, Hidalgo, P, Trapero-Bertran Marta, Amelia Acera, Rodriguez, Ana, Ana Rodriguez, Soteras, Pilar, Toran, Pere, Acera, A, Manresa, JM, Acera, Amelia, Bonet, Josep M., Prieto, G   +39 more
core   +1 more source

Photodynamic Priming and Minocycline Overcome Chemoresistance by Reprogramming the Pancreatic Tumor Immune Microenvironment In Vivo

Advanced Science, EarlyView.
Dual priming with minocycline and photodynamic priming reprograms the pancreatic tumor microenvironment to overcome chemoresistance. By suppressing DNA repair enzyme Tdp1, inducing photooxidative damage, and enhancing irinotecan delivery via light‐activated nanoencapsulation, this strategy remodels the tumor microenvironment and drives immune ...
Fernanda V. Cabral, Jose Quilez‐Alburquerque, Olivia Mooradian, Shivendran Vytheswarran, Badri Parshad, Girgis Obaid, Huang‐Chiao Huang, Tayyaba Hasan   +7 more
wiley   +1 more source

Measuring Humoral Immune Responses to SARS-CoV-2: A Comprehensive Review of Serological Assays

Vaccines
The COVID-19 pandemic highlighted the critical role of serological assays in understanding antiviral immune responses, monitoring vaccine efficacy, and informing public health strategies.
Huijing Xue, Katarzyna Haynesworth, Heidi A. Hempel, Troy J. Kemp, Ligia A. Pinto   +4 more
doaj   +1 more source

A Pathogenic Role for Splenic B1 Cells in SIV Disease Progression in Rhesus Macaques

Frontiers in Immunology, 2019
B1 cells spontaneously produce protective natural antibodies which provide the first line of defense against a variety of pathogens. Although these natural antibodies share similar autoreactive features with several HIV-1 broadly neutralizing antibodies,
Gospel Enyindah-Asonye, Anthony Nwankwo, Christopher Hogge, Mohammad Arif Rahman, Sabrina Helmold Hait, Ruth Hunegnaw, Eun-Ju Ko, Tanya Hoang, David J. Venzon, Marjorie Robert-Guroff   +9 more
doaj   +1 more source

Rational Design of Broad‐Spectrum Anti‐Enteroviral Molecular Glues Targeting Enteroviral RNAi Suppressors

Advanced Science, EarlyView.
By leveraging this homodimerization mechanism, molecular glues were rationally designed to induce dysfunctional 3A dimerization, thereby restoring antiviral RNAi. The optimal molecular glue, VTP‐32, demonstrated potent and pan‐enterovirus (groups A, B, D) antiviral effects.
Yuan Fang, Xiong Xie, Huidi Fan, Botao Wu, An Wang, Wenhao Dai, Zezhong Liu, Jian Li, Huoyan Tong, Jianan Li, Yujie Ren, Jinlin Wang, Xi Zhou, Hong Liu   +13 more
wiley   +1 more source

Immunological targeting of matrix metalloproteinase-9 as a novel approach to universal cancer vaccine: characterization of anti-cancer antibodies efficacy in vitro [PDF]

, 2020
Objective: Therapeutic approach to cancer based on a vaccine targeting various types of cancer compared to being cancer-type specific has many advantages and can be applied to large population.
V. Ivanov, E. Efremov, A. Niedzwiecki, A. Goc, M. Rath, M. Chatterjee   +5 more
core   +1 more source

A Catalytic Osmium Redox Couple Collapses Cancer Redox Balance

Advanced Science, EarlyView.
A stable Os(III)/Os(IV) redox couple is developed to disrupt the tumor cell redox balance by concurrently catalyzing ROS generation and GSH depletion. Osmium‐treated cells exhibit multiple cell death pathways, including apoptosis, ferroptosis, and immunogenic cell death.
Wan‐Qiong Huang, Tao Huang, Yiming Hao, Gui‐Feng Huang, Yi‐Lang Yan, Xin Fang, Ying Chen, Xiao‐Long Wei, Wai‐Lun Man, Wen‐Xiu Ni   +9 more
wiley   +1 more source