Results 71 to 80 of about 198,762 (311)

Tissue vaccines for cancer

Expert Review of Vaccines, 2007
Most tumors, including prostate carcinoma, are heterogeneous mixtures of neoplastic cells and supporting stromal matrix. Attempts to vaccinate as a means to treat or prevent cancer have typically relied on use of a single antigen or cell type. In the case of whole-cell vaccines, clonal populations of cancer cells are grown in culture and harvested for ...
Mark A, Suckow, Julie, Heinrich, Elliot D, Rosen   +2 more
openaire   +2 more sources

Small Extracellular Vesicles‐Derived Circ6718 Unlocks Stromal Remodeling and Serves as a Biomarker in Gastric Cancer

Advanced Science, EarlyView.
sEVs‐circ6718 serves as a promising serum biomarker for gastric cancer early diagnosis and prognosis, promoting malignant transformation in gastric cancer cells and GC‑MSC differentiation into CAFs. sEVs‑circ6718 holds potential as a biomarker for the early diagnosis and prognostic assessment of gastric cancer.
Fan Zhang, Xueyan Zang, Dongli Wang, Rong Li, Hui Qian, Wenrong Xu, Jiajia Jiang, Yongmin Yan   +7 more
wiley   +1 more source

Assessing VirScan serosurvey epitope profiling variability between in-clinic venous blood draw and capillary blood self-sampling device

Microbiology Spectrum
Timely and ongoing in-clinic sample collections are a common logistical barrier to volunteer participation and retention in longitudinal clinical studies.
Linda M. Sircy, Terry L. Stevens-Ayers, Elizabeth M. Krantz, Laurel Joncas-Schronce, Nina S. O. Ozbek, Rachel L. Blazevic, Larry Mose, Louise E. Kimball, Ryan Basom, Sayan Dasgupta, Antje Heit, Frank Schmitz, David Heckerman, Rachel A. Bender Ignacio, Joshua A. Hill, Jim Boonyaratanakornkit, Michael Boeckh, Alpana Waghmare   +17 more
doaj   +1 more source

A Bayesian approach to infer recombination patterns in coronaviruses

Nature Communications, 2022
Genetic recombination can confound standard phylogenetic approaches. Here, the authors present a method to reconstruct virus recombination networks, and show the importance of recombination in shaping the ongoing evolution of SARS-like, MERS and 3 human ...
Nicola F. Müller, Kathryn E. Kistler, Trevor Bedford   +2 more
doaj   +1 more source

Aptamer‐Engineered Liposomal Platform Enables in Situ cDC1 Vaccination to Potentiate Immunotherapy in Prostate Cancer

Advanced Science, EarlyView.
Prostate cancer is immunologically ‘cold’, with scarce, dysfunctional type 1 conventional dendritic cells (cDC1s) that limit T cell priming. We introduce an aptamer‐targeted liposomedelivering FMS‐like tyrosine kinase 3 ligand (Flt3L) and chlorin e6 (Ce6). Ultrasound induces antigen release and cDC1s recruitment, creating an in situ cDC1 vaccine.
Jiayi Wang, Xuan Wang, Xinfeng Dai, Linxin Tian, Wencheng Shen, Xueliang Liu, Wei Xue, Jiahua Pan, Yu Yang   +8 more
wiley   +1 more source

Improving random forest predictions in small datasets from two-phase sampling designs

BMC Medical Informatics and Decision Making, 2021
Background While random forests are one of the most successful machine learning methods, it is necessary to optimize their performance for use with datasets resulting from a two-phase sampling design with a small number of cases—a common situation in ...
Sunwoo Han, Brian D. Williamson, Youyi Fong   +2 more
doaj   +1 more source

Safety and immunogenicity of a new tuberculosis vaccine, MVA85A, in mycobacterium tuberculosis–infected individuals [PDF]

, 2009
Copyright © 2009 by the American Thoracic Society.Rationale: An effective new tuberculosis (TB) vaccine regimen must be safe in individuals with latent TB infection (LTBI) and is a priority for global health care.
Beveridge, NER, Alder, N, Davies, RJ, Minassian, A, Hill, Adrian, Beveridge, NE, Gleeson, FV, Pasvol, G, Hill, AVS, Mcshane, Helen, Davies, RJO, Van Wijgerden, J, Gleeson, Fergus, Poulton, I, Sander, CR, Pathan, AA, McShane, H, Hill, AV   +17 more
core   +1 more source

FUCA2 Sustains AKT Signaling and Suppresses Senescence by Antagonizing FUT3‐Mediated ErbB3 Fucosylation in Lung Adenocarcinoma

Advanced Science, EarlyView.
ABSTRACT While targeted therapies have improved outcomes in lung adenocarcinoma (LUAD), many patients still lack targetable mutations. Here, we identified alpha‐L‐fucosidase 2 (FUCA2) as a crucial driver of LUAD by preventing cellular senescence. Mechanistically, through the restriction of fucosyltransferase 3 (FUT3)‐mediated α‐1,3‐fucosylation of ...
Lu Chen, Jintao Guo, Fei Li, Mingjie Gao, Runyang Li, Zhaozhang Huang, Yaolin Zheng, Chunyi Gao, Jihuan Hou, Qiang Yu, Bowen Zheng, Xuemei Chen, Wenqing Zhang, Xiaoting Hong, Yali Zheng, Daxuan Wang, Qiyuan Li, Tianhui Hu, Yan‐yan Zhan   +18 more
wiley   +1 more source

Development of a potent monoclonal antibody for treatment of human metapneumovirus infections

Nature Communications
Human metapneumovirus (HMPV) is a major cause of respiratory infections, particularly among vulnerable populations, yet effective therapeutics remain unavailable. Monoclonal antibodies (mAbs) offer a promising approach for treatment and prevention.
Evelyn D. Harris, Morgan McGovern, Sara Pernikoff, Ren Ikeda, Lea Kipnis, William Hannon, Elizabeth B. Sobolik, Matthew Gray, Alexander L. Greninger, Sijia He, Chen-Ni Chin, Tong-Ming Fu, Marie Pancera, Jim Boonyaratanakornkit   +13 more
doaj   +1 more source

Cancer and COVID-19: A review of immune insights and partnerships to inform public health strategy

International Journal of Infectious Diseases
Objective: To summarize current evidence on SARS-CoV-2 vaccine immunogenicity in cancer populations, review the experimental approaches and assays used to evaluate multilayer immunity, and highlight emerging collaborative efforts that support more ...
Heidi Hempel, Huijing Xue, Shin La Shu, Shweta Jain, Troy J. Kemp, Ligia A. Pinto   +5 more
doaj   +1 more source