Results 71 to 80 of about 3,468,016 (309)

Molecular characterization of breast cancer cell lines through multiple omic approaches

Breast Cancer Research, 2017
Background Breast cancer cell lines are frequently used as model systems to study the cellular properties and biology of breast cancer. Our objective was to characterize a large, commonly employed panel of breast cancer cell lines obtained from the ...
Shari E. Smith, Paul Mellor, Alison K. Ward, Stephanie Kendall, Megan McDonald, Frederick S. Vizeacoumar, Franco J. Vizeacoumar, Scott Napper, Deborah H. Anderson   +8 more
doaj   +1 more source

Aptamer‐Engineered Liposomal Platform Enables in Situ cDC1 Vaccination to Potentiate Immunotherapy in Prostate Cancer

Advanced Science, EarlyView.
Prostate cancer is immunologically ‘cold’, with scarce, dysfunctional type 1 conventional dendritic cells (cDC1s) that limit T cell priming. We introduce an aptamer‐targeted liposomedelivering FMS‐like tyrosine kinase 3 ligand (Flt3L) and chlorin e6 (Ce6). Ultrasound induces antigen release and cDC1s recruitment, creating an in situ cDC1 vaccine.
Jiayi Wang, Xuan Wang, Xinfeng Dai, Linxin Tian, Wencheng Shen, Xueliang Liu, Wei Xue, Jiahua Pan, Yu Yang   +8 more
wiley   +1 more source

Sexual behaviors and access to HIV services during the COVID-19 pandemic among cisgender men who have sex with men in Lima, Peru

BMC Public Health
Background The COVID-19 pandemic significantly impacted sexual behaviors, access to health services, and other factors related to HIV vulnerability among sexual and gender minority populations globally.
Kai Vu, Hugo Sánchez, Robinson Cabello, José Hidalgo, Sayan Dasgupta, Ann Duerr, Alexander Lankowski   +6 more
doaj   +1 more source

Cancer trends: Breast, cervical and colorectal cancer 1994-2019: National trends for cancers with population-based screening programmes in Ireland

, 2022
The overall burden of cancer in Ireland is increasing, primarily due to population growth and ageing, with the annual number of cases of breast cancer, cervical cancer and colorectal cancer estimated to increase by 50%, 56% and 113% respectively by 2045 ...
National Cancer Registry Ireland (NCRI)
core  

WT1‐Targeted Oral Bifidobacterium longum Vaccine Enhances Checkpoint Blockade Efficacy in Pancreatic Cancer

Advanced Science, EarlyView.
Oral WT1‐targeted Bifidobacterium longum vaccine promotes WT1‐associated cellular immunity and enhances anti‐PD‐1/anti‐CTLA‐4 efficacy in pancreatic cancer. ABSTRACT Pancreatic ductal adenocarcinoma (PDAC) remains largely unresponsive to immune checkpoint inhibitors (ICI) due to its profoundly immunosuppressive tumor microenvironment.
Taiki Yamazaki, Aori Minami, Misako Hirota, Mirei Hirano, Ryota Sato, Atsuki Honma, Hideto Ueki, Toshiro Shirakawa   +7 more
wiley   +1 more source

Preclinical assessment of a new live attenuated Mycobacterium tuberculosis Beijing-based vaccine for tuberculosis

, 2020
Tuberculosis still claims more lives than any other pathogen, and a vaccine better than BCG is urgently needed. One of the challenges for novel TB vaccines is to protect against all Mycobacterium tuberculosis lineages, including the most virulent ones ...
권기웅, 신성재
core   +1 more source

Engineering Microbial Particles for Next‐Generation Biomedical Platforms

Advanced Science, EarlyView.
Microbe‐derived particles (MDPs), which include extracellular vesicles, outer membrane vesicles, inclusion bodies, polysaccharide particles, and virus‐like particles, represent a rapidly expanding category of bioinspired nanomaterials. With their natural origin, intrinsic biocompatibility, and highly programmable functionality, MDPs serve as a ...
Yuting Li, Yunjie Lu, Ziyan Huang, Jianjiang Chen, Yanbin Liu, Lei Qin, Chao Wang, Yumin Wu   +7 more
wiley   +1 more source

Adolescent BCG revaccination induces a phenotypic shift in CD4+ T cell responses to Mycobacterium tuberculosis

Nature Communications
A recent clinical trial demonstrated that Bacille Calmette-Guérin (BCG) revaccination of adolescents reduced the risk of sustained infection with Mycobacterium tuberculosis (M.tb).
One B. Dintwe, Lamar Ballweber Fleming, Valentin Voillet, John McNevin, Aaron Seese, Anneta Naidoo, Saleha Omarjee, Linda-Gail Bekker, James G. Kublin, Stephen C. De Rosa, Evan W. Newell, Andrew Fiore-Gartland, Erica Andersen-Nissen, M. Juliana McElrath   +13 more
doaj   +1 more source

Nanomaterials for Allergy Diagnosis and Treatment: Advances, Opportunities and Translational Challenges

Advanced Science, EarlyView.
Nanomaterials offer dual applications in allergy management. For diagnosis, nanomaterials enhance analytical sensitivity and improve detection in specific IgE and functional assays such as the basophil activation test (BAT). For allergen‐specific immunotherapy, nanomaterials enable allergen masking and controlled release, and effectively modulate the ...
Madiha Habib, Shan Jiang, Joyce ZX Lee, CW Lim, HL Yeung, Nicki YH Leung, Patrick SC Leung, Ting F Leung, Christine YY Wai   +8 more
wiley   +1 more source

Measuring Humoral Immune Responses to SARS-CoV-2: A Comprehensive Review of Serological Assays

Vaccines
The COVID-19 pandemic highlighted the critical role of serological assays in understanding antiviral immune responses, monitoring vaccine efficacy, and informing public health strategies.
Huijing Xue, Katarzyna Haynesworth, Heidi A. Hempel, Troy J. Kemp, Ligia A. Pinto   +4 more
doaj   +1 more source