Results 51 to 60 of about 3,468,016 (309)

The Changing Landscape of Therapeutic Cancer Vaccines-Novel Platforms and Neoantigen Identification.

, 2021
Therapeutic cancer vaccines, an exciting development in cancer immunotherapy, share the goal of creating and amplifying tumor-specific T-cell responses, but significant obstacles still remain to their success.
Harrington, KJ, Ehrnrooth, E, Cohen, EEW, Jou, J, Zocca, M-B   +4 more
core   +1 more source

A Holistic Platform Approach for Developing Robust Pulmonary mRNA Delivery: Integrating Novel Phenolic Acid‐Derived Ionizable Lipids and Device Engineering

Advanced Functional Materials, EarlyView.
An integrated pulmonary mRNA delivery platform combining novel biodegradable syringic acid‐derived ionizable lipids, design‐of‐experiments formulation optimization, and vibrating‐mesh nebulizer engineering enabled stable aerosolization and efficient lung delivery.
Neha Kaushal, Younan Ma, Asad Khanmohammed, Dipen Parande, Hanming Zhang, Saket Dolare, Juliet Chen, Apiwat Wangweerawong, Saswata Karmakar, Hongfeng Deng, Frank Koppenhagen, Shraddha Sharma, Eric Reyes, Sherry He, Lianne Boeglin, Caroline Woo, Azadeh Paksa, Ayed Allawzi, Anusha Dias, Gregory Troiano, Shrirang Karve, Frank DeRosa   +21 more
wiley   +1 more source

Identification of novel interferon responsive protein partners of human leukocyte antigen A (HLA-A) using cross-linking mass spectrometry (CLMS) approach

Scientific Reports, 2022
The interferon signalling system elicits a robust cytokine response against a wide range of environmental pathogenic and internal pathological signals, leading to induction of a subset of interferon-induced proteins.
Ashita Singh, Monikaben Padariya, Jakub Faktor, Sachin Kote, Sara Mikac, Alicja Dziadosz, Tak W. Lam, Jack Brydon, Martin A. Wear, Kathryn L. Ball, Ted Hupp, Alicja Sznarkowska, Borek Vojtesek, Umesh Kalathiya   +13 more
doaj   +1 more source

Primary and booster immune responses to SA14-14-2 Japanese encephalitis vaccine in Korean infants

, 1999
Attenuated SA14-14-2 Japanese encephalitis (JE) vaccine has been administered safely and effectively to more than 100 million children in China since 1988 and recently, licensure of the vaccine in Korea has been sought.
박민수
core   +1 more source

Reduction of low- and high-grade cervical abnormalities associated with high uptake of the HPV bivalent vaccine in Scotland [PDF]

, 2014
In Scotland, a national HPV immunisation programme began in 2008 for 12-13 year olds, with a catch-up campaign from 2008-2011 for those under the age of 18.
Kavanagh, K, Cruickshank, M, Cubie, H., C Robertson, Pollock, Kevin G.J., J Love, Pollock, K G J, Potts, A., Love, J., K Kavanagh, Cruickshank, M., Nicoll, Sheila, Donaghy, Martin, Palmer, Tim J, K Cuschieri, Robertson, C, Palmer, T J, M Donaghy, Cuschieri, K., Robertson, C., H, Cubie,, Potts, Alison, H Cubie, M Cruickshank, Nicoll, S., Donaghy, M, Pollock, K. G. J., Potts, A, Love, John, Cuschieri, Kate, Kavanagh, K., Donaghy, M., S Nicoll, Cuschieri, K, Cubie, H, Nicoll, S, Cruickshank, Maggie, T J Palmer, Love, J, Kavanagh, Kimberley, K G J Pollock, Robertson, Chris, Palmer, T. J., A Potts   +43 more
core   +1 more source

From Cell‐Derived Vesicles to Hybrid Nanovectors: Biological Membranes as Functional Blueprints for Gene Delivery

Advanced Healthcare Materials, EarlyView.
Biologically derived and hybrid nonviral nanovectors are examined as distinct but convergent design approaches. Integrating synthetic components with biologically functionalized membranes allows efficient interactions with complex cellular environments.
Clara Baldari, Claudia Leone, Gabriella Leccese, Claudia De Stradis, Alessandra Invidia, Concetta Quintarelli, Biagio De Angelis, Franco Locatelli, Giuseppe Gigli, Gabriele Maiorano, Ilaria Elena Palamà   +10 more
wiley   +1 more source

Ionizable Lipid‐Dependent Optimization of Steroid Lipid Nanoparticles With Tunable Immunomodulatory Properties

Advanced Materials, EarlyView.
A novel engineering strategy that establishes material design principles for incorporating anti‐inflammatory steroids into lipid nanoparticles to reduce LNP‐induced inflammation while retaining mRNA delivery. Results are validated in vitro and in three animal models of inflammation and autoimmunity in vivo.
Ajay S. Thatte, Benjamin E. Nachod, Julia Baena, Jenna Muscat‐Rivera, Lesley Chaboub, Hannah C. Safford, Hannah C. Geisler, Hannah M. Yamagata, Melgious J. Y. Ang, Michael Kegel, Alexandre Poirier, Elaine R. Tong, Zhe Zhong, Qiangqiang Shi, Jinjin Wang, Elisa Battistini, Ye Zeng, Alex G. Hamilton, Kelsey L. Swingle, Drew Weissman, Jilian R. Melamed, Michael J. Mitchell   +21 more
wiley   +1 more source

Assessing VirScan serosurvey epitope profiling variability between in-clinic venous blood draw and capillary blood self-sampling device

Microbiology Spectrum
Timely and ongoing in-clinic sample collections are a common logistical barrier to volunteer participation and retention in longitudinal clinical studies.
Linda M. Sircy, Terry L. Stevens-Ayers, Elizabeth M. Krantz, Laurel Joncas-Schronce, Nina S. O. Ozbek, Rachel L. Blazevic, Larry Mose, Louise E. Kimball, Ryan Basom, Sayan Dasgupta, Antje Heit, Frank Schmitz, David Heckerman, Rachel A. Bender Ignacio, Joshua A. Hill, Jim Boonyaratanakornkit, Michael Boeckh, Alpana Waghmare   +17 more
doaj   +1 more source

Anti-proliferative therapy for HIV cure: a compound interest approach

Scientific Reports, 2017
In the era of antiretroviral therapy (ART), HIV-1 infection is no longer tantamount to early death. Yet the benefits of treatment are available only to those who can access, afford, and tolerate taking daily pills. True cure is challenged by HIV latency,
Daniel B. Reeves, Elizabeth R. Duke, Sean M. Hughes, Martin Prlic, Florian Hladik, Joshua T. Schiffer   +5 more
doaj   +1 more source

Vaccine Therapy for the Prostate Cancer

, 2015
The aim of using vaccine in the treatment of prostate cancer (Pca) is to activate immune response against malignant cells by overcoming the tolerance triggered by the tumor.
Cengiz Kara, Mehmet Giray Sönmez
core   +1 more source