Results 51 to 60 of about 198,762 (311)

Estimation of HPV prevalence in young women in Scotland; monitoring of future vaccine impact [PDF]

, 2013
Background Estimation of pre-immunisation prevalence of HPV and distribution of HPV types is fundamental to understanding the subsequent impact of HPV vaccination.
Robertson, Charles, Cubie, Heather, Cuschieri, Kate, Love, John, Potts, Alison, Kavanagh, Kimberley, Pollock, Kevin G.J., Donaghy, Martin, Robertson, Chris, Pollock, Kevin G J, Sinka, Katy   +10 more
core   +1 more source

Exploring an Alternative to mRNA Vaccine Cold Chain Storage: MRNA‐Lipid Nanoparticle Stability When Dried in a Polymer Matrix

Advanced Functional Materials, EarlyView.
The nanostructure, size, and function of mRNA‐loaded lipid nanoparticles are evaluated before drying, within polymer microneedles, and after rehydration. The results reveal the polymer and LNP loadings required to recover nanostructure and preserve the delivery performance in dry‐state formulations.
Brendan P. Dyett, Shahad K. Alsaiari, John L. Daristotle, Timothy A. Forster, Alicia Lau, Dhruv Varshney, Rania Afaneh, Andrew R. Hanna, Charles Sloane, David Mankus, Haitao Yu, Jiali Zhai, DongSoo Yun, Lisa H. Tostanoski, Abigail Lytton‐Jean, Dan H. Barouch, Charlotte E. Conn, Robert Langer, Ana Jaklenec, Calum J. Drummond   +19 more
wiley   +1 more source

Efficacy of a bivalent killed whole-cell cholera vaccine over five years: a re-analysis of a cluster-randomized trial

BMC Infectious Diseases, 2018
Background Oral cholera vaccine (OCV) is a feasible tool to prevent or mitigate cholera outbreaks. A better understanding of the vaccine’s efficacy among different age groups and how rapidly its protection wanes could help guide vaccination policy ...
Youyi Fong, M. Elizabeth Halloran, Jin Kyung Park, Florian Marks, John D. Clemens, Dennis L. Chao   +5 more
doaj   +1 more source

Identification of novel interferon responsive protein partners of human leukocyte antigen A (HLA-A) using cross-linking mass spectrometry (CLMS) approach

Scientific Reports, 2022
The interferon signalling system elicits a robust cytokine response against a wide range of environmental pathogenic and internal pathological signals, leading to induction of a subset of interferon-induced proteins.
Ashita Singh, Monikaben Padariya, Jakub Faktor, Sachin Kote, Sara Mikac, Alicja Dziadosz, Tak W. Lam, Jack Brydon, Martin A. Wear, Kathryn L. Ball, Ted Hupp, Alicja Sznarkowska, Borek Vojtesek, Umesh Kalathiya   +13 more
doaj   +1 more source

Host genetic factors in hepatitis B infection, liver cancer and vaccination response: a review with a focus on Africa. [PDF]

, 2012
The disease burden due to hepatitis B virus (HBV) infection remains significant; 350 million people are infected world-wide, and around half a million deaths each year are due to HBV-related liver disease and hepatocellular carcinoma (HCC).
Hall, Andrew J, Andrew J. Hall, Branwen J. Hennig, Hennig, Branwen J   +3 more
core   +1 more source

Individual-level factors associated with COVID-19 vaccine acceptance among U.S. patients with cancer

, 2022
INTRODUCTION: Vaccine hesitancy in the wake of the COVID-19 pandemic is a major public health concern in the US. Cancer patients are especially vulnerable to adverse COVID-19 outcomes and require targeted prevention efforts against COVID-19.
Oswald, Laura B., Penedo, Frank J., Hathaway, Cassandra A, Peoples, Anita R., Ulrich, Cornelia M, Oswald, Laura B, Siegel, Erin M., Tworoger, Shelley S., Ulrich, Cornelia M., Islam, Jessica Y, Siegel, Erin M, Peoples, Anita R, Hathaway, Cassandra A., Penedo, Frank J, Gonzalez, Brian D., Tworoger, Shelley S, Gonzalez, Brian D, Islam, Jessica Y.   +17 more
core   +1 more source

Bacteria‐Responsive Nanostructured Drug Delivery Systems for Targeted Antimicrobial Therapy

Advanced Materials, EarlyView.
Bacteria‐responsive nanocarriers are designed to release antimicrobials only in the presence of infection‐specific cues. This selective activation ensures drug release precisely at the site of infection, avoiding premature or indiscriminate release, and enhancing efficacy.
Guillermo Landa, Gracia Mendoza, Silvia Irusta, Manuel Arruebo   +3 more
wiley   +1 more source

Specifically modified Env immunogens activate B-cell precursors of broadly neutralizing HIV-1 antibodies in transgenic mice

Nature Communications, 2016
The induction of broadly neutralizing antibodies (bNAbs) is a goal of HIV-1 vaccine research. Here the authors demonstrate the ability of an HIV Env-derived immunogen to bind germline precursors of a class of bNAbs and to activate the corresponding B ...
Andrew T. McGuire, Matthew D. Gray, Pia Dosenovic, Alexander D. Gitlin, Natalia T. Freund, John Petersen, Colin Correnti, William Johnsen, Robert Kegel, Andrew B. Stuart, Jolene Glenn, Michael S. Seaman, William R. Schief, Roland K. Strong, Michel C. Nussenzweig, Leonidas Stamatatos   +15 more
doaj   +1 more source

DataPackageR: Reproducible data preprocessing, standardization and sharing using R/Bioconductor for collaborative data analysis [version 2; referees: 2 approved, 1 approved with reservations]

Gates Open Research, 2018
A central tenet of reproducible research is that scientific results are published along with the underlying data and software code necessary to reproduce and verify the findings.
Greg Finak, Bryan Mayer, William Fulp, Paul Obrecht, Alicia Sato, Eva Chung, Drienna Holman, Raphael Gottardo   +7 more
doaj   +1 more source

Cancer-targeted BikDD gene therapy elicits protective antitumor immunity against lung cancer

, 2011
[[abstract]]Targeted cancer-specific gene therapy is a promising strategy for treating metastatic lung cancer, which is a leading cause of lung cancer-related deaths.
Sher, YP;Liu, SJ;Chang, CM;Lien, SP;Chen, CH;Han, ZB;Li, LY;Chen, JS;Wu, CW;Hung, MC
core   +1 more source