Results 161 to 170 of about 187,608 (218)

RNA‐centric world of retroviruses: unravelling the molecular strategies of genomic RNA packaging

Biological Reviews, EarlyView.
ABSTRACT Retroviruses constitute a unique group of RNA viruses that have profoundly influenced both evolutionary trajectories and biomedical research. Their ability to reverse transcribe and integrate into host genomes has shaped genomic architecture across species and contributed to our understanding of oncogenes, gene regulation, and RNA biology ...
Mohammad Abdullah Jehad, Suresha G. Prabhu, Lizna M. Ali, Vineeta N. Pillai, Farah Mustafa, Tahir A. Rizvi   +5 more
wiley   +1 more source

Antigen cross-presentation potentiating cancer vaccine adjuvant for T cell expansion and synergy with anti-PD-1. [PDF]

NPJ Vaccines
Dang GC, Loeurng V, Pa P, Seng CY, Lee SE, Rhee JH.   +5 more
europepmc   +1 more source

Screening of bispecific antibodies during single cell cloning of recombinant Chinese hamster ovary cell lines to improve titer and product quality

Biotechnology Progress, EarlyView.
Abstract Development of therapeutic bispecific antibodies (BsAbs) poses significant manufacturability challenges associated with correct chain pairing and an increased diversity of impurities. Here we address this with a product quality assessment during cell line development (CLD), forgoing the need for genetic characterization during cell line ...
Molly Robinson, Jessica Willmott, Holly Corrigall, Daniela Lega, Joseph Stirling, Vithiya Vimalraj, Mitul Patel, Robyn Emmins   +7 more
wiley   +1 more source

Leveraging glucan-induced trained immunity for the epigenetic and metabolic rewiring of macrophages to enhance colorectal cancer vaccine response. [PDF]

Nat Commun
Hamdan F, Gandolfi S, D'Alessio F, Giannoula Y, Kolikova J, Fusciello M, Zaghen E, Napolano A, Russo S, Izci O, Bottega P, Chiaro J, Alanen KM, Antignani G, Feodoroff M, Stigzelius V, Sakalauskaite M, Sandberg J, Nieminen AI, Zambrano N, Eriksson O, Mustjoki S, Seppälä TT, Grönholm M, Cerullo V.   +24 more
europepmc   +1 more source

Antimicrobial Peptides and Peptidomimetics in Foods – A Synthetic Foray

ChemFoodChem, EarlyView.
This Review discusses AMPs in foods and their syntheses. It espouses facile methods to make them accessible and suggests their utility in the mitigation and eradication of the burgeoning maladies of antimicrobial and multidrug resistance (AMR and MDR).
Josephat U. Izunobi, Adejoke D. Osinubi, Abosede A. Badeji   +2 more
wiley   +1 more source

Shared neoantigens' atlas for off-the-shelf cancer vaccine development. [PDF]

J Transl Med
Mauriello A, Cavalluzzo B, Ragone C, Tagliamonte M, Buonaguro L.   +4 more
europepmc   +1 more source

A Stable Isopterin Mimic of a Potent Bacterial Stimulant of T Cells

Chemistry – A European Journal, EarlyView.
A microbial metabolite covalently binds immunological protein MR1 to potently activate specific lymphocytes called MAIT cells, but it is too unstable for biological applications. Here, using synthesis, assays, protein crystallography, and computer modelling, we report a water‐stable analogue that activates reporter cells expressing the MAIT T cell ...
Jeffrey Y. W. Mak, Huy N. Hoang, Wael Awad, Xin Yi Lim, Damica D. Laurie, Ryan J. D. Rivero, James McCluskey, Alexandra J. Corbett, Jamie Rossjohn, David P. Fairlie   +9 more
wiley   +1 more source

A Programmable Nanovaccine Platform Based on M13 Bacteriophage for Personalized Cancer Vaccine and Therapy. [PDF]

Adv Mater
Huang S, He Y, Madow A, Peng H, Griffin M, Qi J, Huang M, Amoroso H, Abrashoff R, Heldman N, Belcher AM.   +10 more
europepmc   +1 more source

Chemical engineering as an essential element of industrial biotechnology in Mexico: New aims in research and university education

The Canadian Journal of Chemical Engineering, EarlyView.
Abstract On the centennial of higher education in Chemical Engineering in Mexico, it is pertinent to revisit the key stages that have contributed to its consolidation as a vital discipline for the nation's scientific and technological advancement. Although the initial mission of chemical engineering education was primarily oriented toward the training ...
Agustín López Munguía, Octavio T. Ramírez, Rafael Vazquez‐Duhalt, Eduardo Bárzana   +3 more
wiley   +1 more source

UK cancer vaccine advance - Recognising and realising opportunities. [PDF]

Camb Prism Precis Med
Craddock C, Earwaker P, Fittall M, Fontana E, Ganesh D, Gerlinger M, Ghafoor Q, Jones RP, Kunene V, Lee L, Lee R, Lee SM, Linch M, Little M, Liu J, McKenzie H, Petty R, Pinato DJ, Powles T, Protheroe A, Robinson T, Ross PJ, Shiu KK, Spicer J, Symeonides S, Tilby M, Vimalachandran D, Wang JY, Wardley A, Winter H.   +29 more
europepmc   +1 more source