Results 211 to 220 of about 174,873,894 (246)

PPP2R2C promotes aerobic glycolysis and mediates pemetrexed resistance in lung adenocarcinomas by upregulating TCP1-dependent protein folding of glycolytic enzymes. [PDF]

Respir Res
Chen J, Wang X, Wang Z, Li G, Han F.
europepmc   +1 more source

Magnetoreceptor Promotes Hepatocellular Carcinoma Development and Blunts Sorafenib‐Induced Ferroptosis by Regulating Iron Homeostasis

Advanced Science, EarlyView.
Magnetoreceptor (MagR) regulates iron homeostasis and mitochondrial function in hepatocellular carcinoma (HCC) cells. Specifically, MagR deficiency suppresses tumor cell proliferation, migration, and invasion and enhances sorafenib‐induced ferroptosis through iron accumulation.
Tao Wang, Chenghua Song, Xin He, Mengzhou Wang, Wuming Liu, Xiaolin Wang, Yuanyuan Zhang, Jia Zhang, Lin Zhang, Dan Li, Yu Zhang, Zheng Wu, Yi Lyu, Rongqian Wu   +13 more
wiley   +1 more source

Shikonin triggers apoptosis in lung adenocarcinoma through the FHL2-FOXO1 signaling axis. [PDF]

J Transl Med
Chen S, Zhou M, Zhang W, Zhong J, Han W, Wang Z, Wang S, Gu C, Yu Z, Zhao S.   +9 more
europepmc   +1 more source

LAPTM5 Downregulation‐Driven VAMP8 Phosphorylation Impairs Autophagosome‐Lysosome Fusion and Aggravates Septic Acute Lung Injury

Advanced Science, EarlyView.
LAPTM5 functions as a critical molecular scaffold bridging PGAM5 and VAMP to facilitate PGAM5‐mediated dephosphorylation of VAMP8. This cascade promotes autophagosome‐lysosome fusion, restores impaired autophagic flux, and clears damaged mitochondria, thereby mitigating cellular oxidative stress and systemic inflammation.
Lang Jiang, Qilan Li, Hao Liu, Xuehui Gao, Hongyu Nie, Lang Chen, Mei He, Xuefeng Li, Xiangming Fang, Jiqian Xu, Hao Zhang, Jiahong Xia, You Shang   +12 more
wiley   +1 more source

FOXO1 Is Required for Growth and Viability of Cancer-Associated Fibroblasts in Human Breast Carcinomas. [PDF]

Genes Cells
Koyama T, Kobayashi T, Mezawa Y, Gao W, Yamada K, Yamashita K, Wang Z, Koyama Y, Abe M, Maruyama R, Yang L, Daitoku H, Fukamizu A, Takano A, Miyagi Y, Yokose T, Yamashita T, Sugahara K, Seimiya H, Daigo Y, Katakura A, Orimo A.   +21 more
europepmc   +1 more source

USP4‐Dependent CHAF1B Stabilization Regulates Distinct SETDB1 Ubiquitin States Linked to AKT T308 Signaling and Lipogenic Remodeling in HCC

Advanced Science, EarlyView.
USP4 stabilizes CHAF1B by limiting K48‐linked ubiquitination. Stabilized CHAF1B supports UHRF1‐associated K63‐linked SETDB1 ubiquitination and cytoplasmic redistribution, whereas CHAF1B loss favors VHL‐dependent K11‐associated degradative ubiquitination and proteasomal loss of SETDB1.
Saiyan Bian, Yun Tong, Wenkai Ni, Zhangzhi Tang, Weiting Chen, Kexin Ma, Lihan Jiang, Jiayu Shao, Xuyang He, Wenjie Zheng   +9 more
wiley   +1 more source

The Impact of Aging on the Tongue Proteome. [PDF]

Muscles
Ohlendieck K, Zweyer M, Nebeling F, Swandulla D, Dowling P.   +4 more
europepmc   +1 more source

PTEN enhances the radiosensitivity of melanoma by inhibiting DNA-PKcs. [PDF]

Front Cell Dev Biol
Zhu S, Xu H, Shen F, Chen F, Wang Y.
europepmc   +1 more source

Autophagy-Apoptosis Crosstalk in Cancer: Mechanisms, Signaling Pathways, and Therapeutic Targeting. [PDF]

Cancers (Basel)
Kakkar D, Saxena S, Dhawan U, Dosi N, Khanna C, Paul S.   +5 more
europepmc   +1 more source

Palmitic Acid Inhibits the Proliferation and Hypertrophy of Antler Chondrocytes by Disrupting Mitochondria-Associated Endoplasmic Reticulum Membrane Function. [PDF]

Antioxidants (Basel)
Zhang Q, Yang Z, Yao X, Xing Y, Wang C, Li B, Yue Z, Guo B.   +7 more
europepmc   +1 more source