Results 221 to 230 of about 174,873,894 (246)
An ALKBH3 Inhibitor HUHS199 Suppresses Proliferation of Glioblastoma Cells by Targeting 1-Methyladenosine on GADD45A mRNA. [PDF]
Chem Biol Drug DesYamada M +10 more
europepmc +1 more source
Differential KEAP1/NRF2 mediated signaling widens the therapeutic window of redox-targeting drugs in SCLC therapy. [PDF]
Nat CommunSamarin J +27 more
europepmc +1 more source
The Expression of Cancerous Inhibitor Protein Phosphatase 2A in Chronic Rhinosinusitis With Nasal Polyps [PDF]
Acta Oto-Laryngologica, 2016 The study suggests that cancerous inhibitor of protein phosphatase 2A (CIP2A) expression and eosinophilia associate with chronic rhinosinusitis with nasal polyps with aspirin exacerbated respiratory disease (CRSwNP + AERD). Further studies with a larger sample size are needed to evaluate further the role of CIP2A and related pathways in CRSwNP + AERD ...
Paula Kauppi +2 more
exaly +6 more sources
Cancerous Inhibitor of Protein Phosphatase 2A, an Emerging Human Oncoprotein and a Potential Cancer Therapy Target [PDF]
Cancer Research, 2013 Abstract Protein phosphatase 2A (PP2A) complexes function as tumor suppressors by inhibiting the activity of several critical oncogenic signaling pathways. Consequently, inhibition of the PP2A phosphatase activity is one of many prerequisites for the transformation of normal human cells into cancerous cells.
Jukka Westermarck +2 more
exaly +4 more sources
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Gynecologic Oncology, 2011
Cancerous inhibitor of protein phosphatase 2A (CIP2A) is a recently identified oncoprotein stabilizing c-Myc and promoting cell proliferation and transformation. Here we investigated the role of CIP2A in cervical cancer in vivo and in vitro.CIP2A expression was assessed in normal cervical, cervical intraepithelial neoplasia (CIN) I to III and cervical ...
Weiming Zhao, Jihui Jia, Gengyin Zhou
exaly +3 more sources
Cancerous inhibitor of protein phosphatase 2A (CIP2A) is a recently identified oncoprotein stabilizing c-Myc and promoting cell proliferation and transformation. Here we investigated the role of CIP2A in cervical cancer in vivo and in vitro.CIP2A expression was assessed in normal cervical, cervical intraepithelial neoplasia (CIN) I to III and cervical ...
Weiming Zhao, Jihui Jia, Gengyin Zhou
exaly +3 more sources
Apmis, 2015
Cancerous inhibitor of protein phosphatase 2A ( CIP 2A) prevents proteolytic degradation of a universal transcription factor, c‐Myc. Strong CIP 2A expression associates with poor prognosis in early‐stage tongue cancer and in other cancers.
Sanna Toppila-Salmi +2 more
exaly +3 more sources
Cancerous inhibitor of protein phosphatase 2A ( CIP 2A) prevents proteolytic degradation of a universal transcription factor, c‐Myc. Strong CIP 2A expression associates with poor prognosis in early‐stage tongue cancer and in other cancers.
Sanna Toppila-Salmi +2 more
exaly +3 more sources
Clinical Cancer Research, 2020
Abstract Ovarian cancer (OvC) is the deadliest of all female gynecologic malignancies, ranking as the fifth cause of cancer-related deaths among women. High-grade serous epithelial ovarian cancer (HGSOC) accounts for almost 90% of all forms of OvC, remaining as the most lethal subtype of ovarian malignancies.
Rita A. Avelar +3 more
openaire +1 more source
Abstract Ovarian cancer (OvC) is the deadliest of all female gynecologic malignancies, ranking as the fifth cause of cancer-related deaths among women. High-grade serous epithelial ovarian cancer (HGSOC) accounts for almost 90% of all forms of OvC, remaining as the most lethal subtype of ovarian malignancies.
Rita A. Avelar +3 more
openaire +1 more source
American Journal of Respiratory and Critical Care Medicine
Abstract Background, Introduction, or Rationale: The activity of protein phosphatase 2A (PP2A), a serine-threonine phosphatase, is reduced in the lung fibroblasts of idiopathic pulmonary fibrosis (IPF) patients. Chemical reactivation of PP2A can reduce bleomycin-induced fibrosis in a mouse model.
D. Nirmal +13 more
openaire +1 more source
Abstract Background, Introduction, or Rationale: The activity of protein phosphatase 2A (PP2A), a serine-threonine phosphatase, is reduced in the lung fibroblasts of idiopathic pulmonary fibrosis (IPF) patients. Chemical reactivation of PP2A can reduce bleomycin-induced fibrosis in a mouse model.
D. Nirmal +13 more
openaire +1 more source
Zhonghua wei chang wai ke za zhi = Chinese journal of gastrointestinal surgery, 2015
To investigate the expression of cancerous inhibitor of protein phosphatase 2A(CIP2A) in human colorectal cancer, and to examine the association of CIP2A expression with clinicopathology and prognosis.CIP2A expression in colorectal cancer tissue microarray of 92 cases was detected by immunohistochemistry method.Up-regulated CIP2A expression was closely
Xing-yu, Peng +5 more
openaire +1 more source
To investigate the expression of cancerous inhibitor of protein phosphatase 2A(CIP2A) in human colorectal cancer, and to examine the association of CIP2A expression with clinicopathology and prognosis.CIP2A expression in colorectal cancer tissue microarray of 92 cases was detected by immunohistochemistry method.Up-regulated CIP2A expression was closely
Xing-yu, Peng +5 more
openaire +1 more source