Results 71 to 80 of about 20,990 (167)

PP2A: A Promising Biomarker and Therapeutic Target in Endometrial Cancer

Frontiers in Oncology, 2019
Over the last decade, the use of targeted therapies has immensely increased in the treatment of cancer. However, treatment for endometrial carcinomas (ECs) has lagged behind, although potential molecular markers have been identified. This is particularly
Michiel Remmerie, Veerle Janssens
doaj   +1 more source

Identification of Candidate Casein Kinase 2 Substrates in Mitosis by Quantitative Phosphoproteomics

Frontiers in Cell and Developmental Biology, 2017
Protein phosphorylation is a crucial regulatory mechanism that controls many aspects of cellular signaling. Casein kinase 2 (CK2), a constitutively expressed and active kinase, plays key roles in an array of cellular events including transcription and ...
Scott F. Rusin, Mark E. Adamo, Arminja N. Kettenbach, Arminja N. Kettenbach   +3 more
doaj   +1 more source

Glucose deprivation activates a metabolic and signaling amplification loop leading to cell death. [PDF]

, 2012
The altered metabolism of cancer can render cells dependent on the availability of metabolic substrates for viability. Investigating the signaling mechanisms underlying cell death in cells dependent upon glucose for survival, we demonstrate that glucose ...
Graeber, Thomas G, Graham, Nicholas A, Kohli, Bitika, Komisopoulou, Evangelia, Lo, Roger S, Mellinghoff, Ingo K, Mischel, Paul S, Ribas, Antoni, Tahmasian, Martik, Teitell, Michael A, Vivanco, Igor, Wu, Hong, Zhu, Maggie   +12 more
core  

Quantitative proteomics to characterize specific histone H2A proteolysis in chronic lymphocytic leukemia and the myeloid THP-1 cell line [PDF]

, 2014
Proteome studies on hematological malignancies contribute to the understanding of the disease mechanism and to the identification of new biomarker candidates.
Deforce, Dieter, Dhaenens, Maarten, Glibert, Pieter, Kipps, Thomas, Lambrecht, Stijn, Offner, Fritz, Van Nieuwerburgh, Filip, Van Steendam, Katleen, Vossaert, Liesbeth   +8 more
core   +3 more sources

CIP2A mediates fibronectin-induced bladder cancer cell proliferation by stabilizing β-catenin

Journal of Experimental & Clinical Cancer Research, 2017
Background Fibronectin (FN) is associated with tumorigenesis and progression in bladder cancer, however, the underlying mechanisms causing this remain largely unknown.
Fengbin Gao, Tianyuan Xu, Xianjin Wang, Shan Zhong, Shanwen Chen, Minguang Zhang, Xiaohua Zhang, Yifan Shen, Xiaojing Wang, Chen Xu, Zhoujun Shen   +10 more
doaj   +1 more source

Induced cancer stem-like cells as a model for biological screening and discovery of agents targeting phenotypic traits of cancer stem cell [PDF]

, 2014
Cancer stem cells (CSCs) retain the capacity to propagate themselves through self-renewal and to produce heterogeneous lineages of cancer cells constituting the tumor.
Akutsu, Hidenori, Kimura, Hirokazu, Kudoh, Ayumi, Lee, Sam W., Nishi, Mayuko, Ryo, Akihide, Umezawa, Akihiro, Yamamoto, Naoki   +7 more
core   +1 more source

Inhibitors of phosphoprotein phosphatases 1 and 2A cause activation of a 53 kDa protein kinase accompanying the apoptotic response of breast cancer cells [PDF]

FEBS Letters, 1997
Treatment of MCF‐7 breast cancer cells with 50 nM okadaic acid triggers an apoptotic response which is accompanied by a 7‐fold increase in the activity of a protein kinase with a relative molecular mass of 53 kDa. The activity of the kinase was stimulated by cell treatment with inhibitors of phosphoprotein phosphatase 1 and 2A, but not by stressing ...
ROSSINI, Gian Paolo, C. PINNA, R. VIVIANI   +2 more
openaire   +3 more sources

Wnt signaling exerts an antiproliferative effect on adult cardiac progenitor cells through IGFBP3. [PDF]

, 2011
RATIONALE: Recent work in animal models and humans has demonstrated the presence of organ-specific progenitor cells required for the regenerative capacity of the adult heart.
Bauer, Michael, Bayomy, Ahmad F, Biechele, Travis L, Conyers, Frank, Crapps, Dylan, Dong, Hanhua, Fine, Gabriel C, Force, Thomas, Guan, Jian, Han, Jung-Kyu, Liao, Annette, Liao, Ronglih, Moon, Randall T, Oikonomopoulos, Angelos, Sereti, Konstantina-Ioanna, Westerman, Karen   +15 more
core   +2 more sources

The protein phosphatase 4 - PEA15 axis regulates the survival of breast cancer cells [PDF]

, 2016
BACKGROUND: The control of breast cell survival is of critical importance for preventing breast cancer initiation and progression. The activity of many proteins which regulate cell survival is controlled by reversible phosphorylation, so that the ...
Mohammed, Hiba N., Mourtada-Maarabouni, Mirna, Pickard, Mark R.   +2 more
core   +4 more sources

The concept of the okadaic acid class of tumor promoters is revived in endogenous protein inhibitors of protein phosphatase 2A, SET and CIP2A, in human cancers [PDF]

Journal of Cancer Research and Clinical Oncology, 2018
The okadaic acid class of tumor promoters, which are inhibitors of protein phosphatases 1 and 2A (PP1 and PP2A), induced tumor promotion in mouse skin, rat glandular stomach, and rat liver. Endogenous protein inhibitors of PP2A, SET and CIP2A, were up-regulated in various human cancers, so it is vital to review the essential mechanisms of tumor ...
Hirota Fujiki, Eisaburo Sueoka, Tatsuro Watanabe, Masami Suganuma   +3 more
openaire   +2 more sources