Results 51 to 60 of about 174,873,894 (246)

Enhanced insulin sensitivity associated with provision of mono and polyunsaturated fatty acids in skeletal muscle cells involves counter modulation of PP2A [PDF]

, 2014
Aims/HypothesisReduced skeletal muscle insulin sensitivity is a feature associated with sustained exposure to excess saturated fatty acids (SFA), whereas mono and polyunsaturated fatty acids (MUFA and PUFA) not only improve insulin sensitivity but blunt ...
Hage Hassan, Rima, Hundal, Harinder S, Gray, Alexander; id_orcid, Lipina Christopher, Hundal, Harinder S., Alexander Gray, Hajduch, Eric, Rima Hage Hassan, David Magill, Eric Hajduch, Hage Hassan Rima, Nardi, Francesca, Francesca Nardi, Hajduch Eric, Magill David, Gray, Alexander, Hundal Harinder S., Lipina, Christopher, Nardi Francesca, Harinder S Hundal, Magill, David, Christopher Lipina, Gray Alexander   +22 more
core   +2 more sources

Targeting SET to restore PP2A activity disrupts an oncogenic CIP2A-feedforward loop and impairs triple negative breast cancer progressionResearch in context

EBioMedicine, 2019
Background: Triple-negative breast cancer (TNBC) remains difficult to be targeted. SET and cancerous inhibitor of protein phosphatase 2A (CIP2A) are intrinsic protein-interacting inhibitors of protein phosphatase 2A (PP2A) and frequently overexpressed in
Chun-Yu Liu, Tzu-Ting Huang, Yi-Ting Chen, Ji-Lin Chen, Pei-Yi Chu, Chun-Teng Huang, Wan-Lun Wang, Ka-Yi Lau, Ming-Shen Dai, Chung-Wai Shiau, Ling-Ming Tseng   +10 more
doaj   +1 more source

CIP2A Causes Tau/APP Phosphorylation, Synaptopathy, and Memory Deficits in Alzheimer’s Disease

Cell Reports, 2018
Summary: Protein phosphatase 2A (PP2A) inhibition causes hyperphosphorylation of tau and APP in Alzheimer’s disease (AD). However, the mechanisms underlying the downregulation of PP2A activity in AD brain remain unclear.
Yang-Ping Shentu, Yuda Huo, Xiao-Long Feng, James Gilbert, Qing Zhang, Zhen-Yu Liuyang, Xiu-Lian Wang, Guan Wang, Huan Zhou, Xiao-Chuan Wang, Jian-Zhi Wang, You-Ming Lu, Jukka Westermarck, Heng-Ye Man, Rong Liu   +14 more
doaj   +1 more source

Monotherapy efficacy of blood-brain barrier permeable small molecule reactivators of protein phosphatase 2A in glioblastoma [PDF]

, 2020
Glioblastoma is a fatal disease in which most targeted therapies have clinically failed. However, pharmacological reactivation of tumour suppressors has not been thoroughly studied as yet as a glioblastoma therapeutic strategy.
Laakkonen, Pirjo,, Leenders, William P. J., Nelander, Sven, Le Joncour, Vadim, Laakkonen, Pirjo, Leenders, William P. J.,, Narla, Goutham, Ohlmeyer, Michael,, Kastrinsky, David B., Doroszko, Milena,, Le Joncour, Vadim,, Denisova, Oxana, Westermarck, Jukka, Johansson, Patrik, Nelander, Sven,, Narla, Goutham,, Kastrinsky, David B.,, Ohlmeyer, Michael, Johansson, Patrik,, Denisova, Oxana, V,, Merisaari, Joni, Denisova, Oxana, V, Doroszko, Milena, Merisaari, Joni,, Zaware, Nilesh,, Zaware, Nilesh, Westermarck, Jukka,, Joncour, Vadim Le, Doroszko M, Westermarck J, Le Joncour V, Laakkonen P, Nelander S, Leenders WPJ, Ohlmeyer M, Leenders, W.P.J., Kastrinsky DB, Zaware N, Merisaari J, Johansson P, Denisova OV, Narla G   +41 more
core   +3 more sources

Nutrient/TOR signaling controls adipose mitochondrial transcription factor A (TFAM) to regulate organismal growth in Drosophila

FEBS Letters, EarlyView.
Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas, Shahoon Khan, Abhishek Sharma, Byoungchun Lee, Savraj S. Grewal   +4 more
wiley   +1 more source

Expression of CIP2A and CD44v6 in condyloma acuminatum-involved skin and its correlation with patients' prognosis

Pifu-xingbing zhenliaoxue zazhi
Objective To investigate the expression levels of cancerous inhibitor of protein phosphatase 2A (CIP2A) and CD44v6 in condyloma acuminatum (CA)-involved skin and to analyze the correlation between their expression and the distribution of HPV genotypes in
ZHANG Yijie, YANG Can, LIN Yongli
doaj   +1 more source

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

A role for eIF5A in translational control of stress‐inducible proteins in multiple myeloma cell lines

Molecular Oncology, EarlyView.
Loss of eIF5A rewires thapsigargin‐mediated endoplasmic reticulum stress responses in multiple myeloma cells by selective translation of mRNA transcripts, consequently dampening thapsigargin‐induced unfolded protein response (UPR) activation and shifting the balance from induction of apoptosis toward cell survival and proliferation.
Demi Both, Ingrid A. M. Derks, Raphaël Vanleyssem, Marine Leclercq, Najla El Hachem, Pierre Close, Eric Eldering, Marco Vincent Haselager   +7 more
wiley   +1 more source

p190A/ARHGAP35 and p190B/ARHGAP5 proteins in endometrial cancer: a novel cancer‐relevant paralog interplay

Molecular Oncology, EarlyView.
This study identifies ARHGAP5, in addition to the frequently mutated ARHGAP35, as significantly mutated in endometrial cancer. Mutations in both genes co‐occur and are associated with their correlated downregulation. Functional CRISPR studies show that both paralogs regulate similar pathways, including actin cytoskeleton organization.
Mathilde Pinault, Capucine Heraud, Mélissa Correia de Oliveira, Véronique Neaud, Valérie Valesco, Valérie Prouzet‐Mauleon, Béatrice Turcq, Jean‐William Dupuy, Anne‐Aurélie Raymond, Sabrina Croce, Frédéric Saltel, Valérie Lagrée, Violaine Moreau   +12 more
wiley   +1 more source

The concept of the okadaic acid class of tumor promoters is revived in endogenous protein inhibitors of protein phosphatase 2A, SET and CIP2A, in human cancers [PDF]

Journal of Cancer Research and Clinical Oncology, 2018
The okadaic acid class of tumor promoters, which are inhibitors of protein phosphatases 1 and 2A (PP1 and PP2A), induced tumor promotion in mouse skin, rat glandular stomach, and rat liver. Endogenous protein inhibitors of PP2A, SET and CIP2A, were up-regulated in various human cancers, so it is vital to review the essential mechanisms of tumor ...
Hirota Fujiki, Eisaburo Sueoka, Tatsuro Watanabe, Masami Suganuma   +3 more
openaire   +2 more sources