Results 41 to 50 of about 174,873,894 (246)

Ets1 and Elk1 transcription factors regulate cancerous inhibitor of protein phosphatase 2A expression in cervical and endometrial carcinoma cells. [PDF]

Transcription, 2012
Cancerous inhibitor of protein phosphatase 2A (CIP2A) has been identified as a proto-oncogene that is overexpressed in various types of human cancers. CIP2A acts by inhibiting protein phosphatase 2A-dependent destabilization of c-Myc, resulting in increased cell proliferation.
Pallai R, Bhaskar A, Sodi V, Rice LM.
europepmc   +4 more sources

Cancerous inhibitor of protein phosphatase 2A (CIP2A) is an independent prognostic marker in wild-type KRAS metastatic colorectal cancer after colorectal liver metastasectomy. [PDF]

BMC Cancer, 2015
The impact of KRAS signaling on cancerous inhibitor of protein phosphatase 2A (CIP2A) expression has not yet been explored. We investigated the impact of KRAS on CIP2A expression in colorectal cancer patients after colorectal liver metastasectomy.We examined CIP2A expression by immunohistochemistry (IHC) and used direct sequencing to identify the ...
Chen KF, Yen CC, Lin JK, Chen WS, Yang SH, Jiang JK, Lan YT, Lin CC, Yu HC, Hsu HM, Lin WL, Teng HW.   +11 more
europepmc   +4 more sources

Analysis of the structure and function of protein phosphatase 2A [PDF]

, 2004
One of the hallmarks of a living organism is the ability to respond to intra- or extracellular changes. These responses involve panoply of enzymes mediating signals through the cell and regulating distinct cellular functions.
Schmidt, Karsten
core   +1 more source

Tamoxifen induces apoptosis through cancerous inhibitor of protein phosphatase 2A-dependent phospho-Akt inactivation in estrogen receptor-negative human breast cancer cells. [PDF]

Breast Cancer Res, 2014
Abstract Introduction Tamoxifen, a selective estrogen receptor (ER) modulator, may affect cancer cell survival through mechanisms other than ER antagonism. In the present study, we tested the efficacy of tamoxifen in a panel of ER-negative breast cancer cell lines and examined the drug mechanism.
Liu CY, Hung MH, Wang DS, Chu PY, Su JC, Teng TH, Huang CT, Chao TT, Wang CY, Shiau CW, Tseng LM, Chen KF.   +11 more
europepmc   +4 more sources

PPP2R4 (protein phosphatase 2A activator, regulatory subunit 4) [PDF]

, 2010
Review on PPP2R4 (protein phosphatase 2A activator, regulatory subunit 4), with data on DNA, on the protein encoded, and where the gene is ...
V Janssens, Janssens, V, Janssens, Veerle   +2 more
core   +1 more source

The TriTryp phosphatome:analysis of the protein phosphatase catalytic domains [PDF]

, 2007
Background The genomes of the three parasitic protozoa Trypanosoma cruzi, Trypanosoma brucei and Leishmania major are the main subject of this study. These parasites are responsible for devastating human diseases known as Chagas disease, African sleeping
Szoor, Balazs; id_orcid, Tabernero, Lydia, Tabernero, Lydia; id_orcid, McElhinney, Helen, Huxley-Jones, Julie, Julie Huxley-Jones, Brenchley, Rachel, Tariq, Humera, Helen McElhinney, Keith Matthews, Matthews, Keith; id_orcid, Rachel Brenchley, Robert Stevens, Szöor, Balázs, Humera Tariq, Lydia Tabernero, Stevens, Robert, Matthews, Keith, Balazs Szoor   +18 more
core   +1 more source

The rim15-Endosulfine-PP2ACdc55 signalling module regulates entry into gametogenesis and quiescence via distinct mechanisms in budding yeast [PDF]

, 2013
Quiescence and gametogenesis represent two distinct survival strategies in response to nutrient starvation in budding yeast. Precisely how environmental signals are sensed by yeast cells to trigger quiescence and gametogenesis is not fully understood.
Sourav Sarkar, Dalgaard Jacob Z., Prakash Arumugam, Arumugam P., Sarkar, Sourav, Jonathan B. A. Millar, Sarkar S., Arumugam Prakash, Millar, Jonathan B. A., Jacob Z. Dalgaard (303312), Jacob Z. Dalgaard, Arumugam, Prakash, Sourav Sarkar (430861), Millar Jonathan B. A., Jonathan B. A. Millar (430863), Sarkar Sourav, Millar J.B.A., Jonathan B A Millar, Dalgaard, Jacob Z., Jacob Z Dalgaard, Dalgaard J.Z., Prakash Arumugam (303310)   +21 more
core   +1 more source

Cucurbitacin B Induces the Lysosomal Degradation of EGFR and Suppresses the CIP2A/PP2A/Akt Signaling Axis in Gefitinib-Resistant Non-Small Cell Lung Cancer

Molecules, 2019
Non-small cell lung cancer (NSCLC) patients carrying an epidermal growth factor receptor (EGFR) mutation are initially sensitive to EGFR-tyrosine kinase inhibitors (TKIs) treatment, but soon develop an acquired resistance.
Pengfei Liu, Yuchen Xiang, Xuewen Liu, Te Zhang, Rui Yang, Sen Chen, Li Xu, Qingqing Yu, Huzi Zhao, Liang Zhang, Ying Liu, Yuan Si   +11 more
doaj   +1 more source

INVESTIGATION OF SALİVARY MIR-9 AND SERUM CIP2A LEVELS IN FANCONI ANEMIA PATIENTS AT HIGH RISK OF DEVELOPING ORAL SQUAMOUS CELL CARCINOMA

Hematology, Transfusion and Cell Therapy, 2023
Objective: Fanconi anemia (FA) is a rare bone marrow failure syndrome caused by mutations in DNA repair genes, and the risk of developing Oral Squamous Cell Carcinoma (OSCC) in FA patients is higher than in the normal population and is seen at younger ...
Zişan Asal Kılıç, Çetin Timur, Tülin Tiraje Celkan, Şahin Öğreden, Nevin Yalman   +4 more
doaj   +1 more source

Prognostic value of the NLR combined with CIP2A in the serum of patients with colorectal cancer

BMC Surgery, 2021
Objective This study aimed to investigate the prognostic value of CIP2A (cancerous inhibitor of protein phosphatase 2A) and the NLR (neutrophil–lymphocyte ratio) in the serum of patients with CRC (colorectal cancer) after resection.
Wei Chen, Hong-Jun Yi, Xiao-Qiong Chen, Wan-Zhen Xie, Xing-kui Tang, Jun-Wen Ye, Xiang Peng, Yan Zhang, Jing-Lin Liang, Mei-Jin Huang   +9 more
doaj   +1 more source