Results 31 to 40 of about 174,873,894 (246)

Deregulation of protein phosphatase 2A inhibitor SET is associated with malignant progression in breast cancer [PDF]

Scientific Reports, 2021
Abstract To understand the mechanism underlying metastasis, identification of a mechanism-based and common biomarker for circulating tumour cells (CTCs) in heterogenous breast cancer is needed. SET, an endogenous inhibitor of protein phosphatase 2A, was overexpressed in all subtypes of invasive breast carcinoma ...
Katsunori Tozuka, Pattama Wongsirisin, Shigenori E. Nagai, Yasuhito Kobayashi, Miki Kanno, Kazuyuki Kubo, Ken Takai, Kenichi Inoue, Hiroshi Matsumoto, Yoshihito Shimizu, Masami Suganuma   +10 more
openaire   +4 more sources

MicroRNA-383-5p acts as a prognostic marker and inhibitor of cell proliferation in lung adenocarcinoma by cancerous inhibitor of protein phosphatase 2A. [PDF]

Oncol Lett, 2017
Lung cancer is the leading cause of cancer-associated mortality worldwide. MicroRNAs (miRNAs/miRs) serve a role in the occurrence and development of lung cancer. The aim of the present study was to analyze the expression and function of the proliferation-associated miR-383-5p in lung adenocarcinoma (LAC).
Zhao S, Gao X, Zang S, Li Y, Feng X, Yuan X.   +5 more
europepmc   +4 more sources

Expression of cancerous inhibitor of protein phosphatase 2A in human triple negative breast cancer correlates with tumor survival, invasion and autophagy. [PDF]

Oncol Lett, 2016
Cancerous inhibitor of protein phosphatase 2A (CIP2A) is a recently characterized oncoprotein which is involved in the progression of several human malignancies. The present study aimed to investigate its biological function in human triple negative breast cancer (TNBC).
Li S, Feng TT, Guo Y, Yu X, Huang Q, Zhang L, Tang W, Liu Y.   +7 more
europepmc   +4 more sources

Cancerous inhibitor of protein phosphatase 2A contributes to human papillomavirus oncoprotein E7-induced cell proliferation via E2F1. [PDF]

Oncotarget, 2015
Cancerous inhibitor of protein phosphatase 2A (CIP2A) is a recently identified oncoprotein that is overexpressed in many human malignant tumors including cervical cancer. Human papillomavirus (HPV) oncoprotein E7 is the key transformation factor in cervical cancer.
Zhang W, Chen H, Chen Y, Liu J, Wang X, Yu X, Chen JJ, Zhao W.   +7 more
europepmc   +3 more sources

MicroRNA-218 inhibits the cell proliferation and migration in clear cell renal cell carcinoma through targeting cancerous inhibitor of protein phosphatase 2A. [PDF]

Oncol Lett, 2019
MicroRNAs (miRs) have emerged as critical modulators of tumor initiation and progression in numerous types of human cancer, including clear cell renal cell carcinoma (ccRCC), which is the most common subtype of renal cell carcinoma. Cancerous inhibitor of protein phosphatase 2A (CIP2A) is a newly characterized oncoprotein and its overexpression has ...
Wei R, Ye X, Zhao Y, Jia N, Liu T, Lian W, Wei H, Zhang G, Song L.   +8 more
europepmc   +4 more sources

Relationship Between CIP2A and Endometrium Cancer [PDF]

, 2020
Objective: To determine whether there is a relationship between endometrium cancer and the oncoprotein cancerous inhibitor of protein phosphatase 2A (CIP2A)
Taskin, Mine Islimye, Akgun, GİZEM, Avcikurt, Ayla Solmaz, Guney, Gurhan, Aslan, FİGEN, Taşkın, Mine İslimye, Akgün, Gizem Akkaş, Avcıkurt, Ayla Solmaz   +7 more
core   +1 more source

Targeting inhibitor 2 of protein phosphatase 2A as a therapeutic strategy for prostate cancer treatment [PDF]

Cancer Biology & Therapy, 2013
Inhibitor 2 of protein phosphatase 2A (I2PP2A), a biological inhibitor of the cellular serine/threonine protein phosphatase PP2A, is associated with numerous cellular processes that often lead to the formation and progression of cancer. In this study we hypothesized that targeting the inhibition of I2PP2A's multiple functions in prostate cancer cells ...
Archana, Mukhopadhyay, Kayann, Tabanor, Rathnam, Chaguturu, Jane V, Aldrich   +3 more
openaire   +2 more sources

Phosphoproteome and drug-response effects mediated by the three protein phosphatase 2A inhibitor proteins CIP2A, SET, and PME-1 [PDF]

, 2022
Protein phosphatase 2A (PP2A) critically regulates cell signaling and is a human tumor suppressor. PP2A complexes are modulated by proteins such as cancerous inhibitor of protein phosphatase 2A (CIP2A), protein phosphatase methylesterase 1 (PME-1), and ...
Pavic K, Aakula A, Aittokallio T, Imanishi SY, Haapaniemi P, Yadav B, Kauko O, Sharma M, Varila T, Reimand J, Wennerberg K, Rupp C, Jumppanen M, Suni V, Ruan L, Kulesskiy E, Yetukuri L, Westermarck J, Laajala TD, Corthals GL   +19 more
core   +1 more source

Erratum: [Corrigendum] Expression of cancerous inhibitor of protein phosphatase 2A in human triple negative breast cancer correlates with tumor survival, invasion and autophagy. [PDF]

Oncol Lett
Li S, Feng TT, Guo Y, Yu X, Huang Q, Zhang L, Tang W, Liu Y.   +7 more
europepmc   +2 more sources

Knockdown of cancerous inhibitor of protein phosphatase 2A may sensitize NSCLC cells to cisplatin [PDF]

Cancer Gene Therapy, 2014
Cancerous inhibitor of protein phosphatase 2A (CIP2A) is a recently identified human oncoprotein that can stabilize some proteins by inhibiting degradation mediated by protein phosphatase 2A (PP2A) and it increases the proliferation of several cancer cells.
L, Wei, W, Qu, J, Sun, X, Wang, L, Lv, L, Xie, X, Song   +6 more
openaire   +2 more sources