Results 81 to 90 of about 20,990 (167)

Chronic p53-independent p21 expression causes genomic instability by deregulating replication licensing [PDF]

, 2016
The cyclin-dependent kinase inhibitor p21WAF1/CIP1 (p21) is a cell-cycle checkpoint effector and inducer of senescence, regulated by p53. Yet, evidence suggests that p21 could also be oncogenic, through a mechanism that has so far remained obscure.
A Duursma, A Viale, AB Niculescu, AC Bester, AC Porter, AJ Holland, Akshay K. Ahuja, Alexander Polyzos, Ana Igea, Angel Nebreda, Antonis Kokkalis, Apolinar Maya-Mendoza, B Langmead, Begoña Canovas, C Delehouzé, C Vaziri, CG Havens, Claus Storgaard Sørensen, CM Beauséjour, CZ Zhang, D Ottaviani, David Walter, Dimitris Kletsas, Dimitris Thanos, E Gibbs, E Petermann, EA Georgakopoulou, EK Benson, EK Papachristou, Emanuel Kanavakis, Emma J. Haagensen, ES Venkatraman, Fani-Marlen Roumelioti, FB Couch, G Velimezi, H Beck, H Li, H Nishitani, HA Sikder, HH Cha, I Iraqui, I Murfuni, IB Roninson, Igor B. Roninson, IS Pateras, J Bartkova, J Essers, J Pines, J Yu, J. Julian Blow, JCF de Winter, JH Barlow, Jiri Bartek, JJ Blow, JJ Blow, JR Rosai, JW Shay, K Chen, K Evangelou, K Hanada, KJ Neelsen, KJ Neelsen, KJ Neelsen, KJ Neelsen, Konstantinos Vougas, M Liontos, M Liontos, M Sideridou, M Terradas, Maria Tzetis, Massimo Lopes, MJ Peart, ML Agarwal, N Rivlin, NA Warfel, ND Perkins, P Karakaidos, Panagiotis Galanos, Paul Townsend, PJ Hastings, PJ Stephens, R Zellweger, RA Burrell, RA Woo, Ralph Zellweger, RH Ramirez-Gonzalez, S Bates, S Gonzalez, S Jørgensen, S Negrini, Sarantis Gagos, Sofia Havaki, Spiros D. Garbis, T Abbas, T Abbas, T Cooks, TD Halazonetis, TG Petrakis, Vassilis G. Gorgoulis, VG Gorgoulis, VN Budhavarapu, Y Wu   +101 more
core   +3 more sources

Phosphoproteome and drug-response effects mediated by the three protein phosphatase 2A inhibitor proteins CIP2A, SET, and PME-1

Journal of Biological Chemistry, 2020
Protein phosphatase 2A (PP2A) critically regulates cell signaling and is a human tumor suppressor. PP2A complexes are modulated by proteins such as cancerous inhibitor of protein phosphatase 2A (CIP2A), protein phosphatase methylesterase 1 (PME-1), and ...
O. Kauko, Susumu Y. Imanishi, Evgeny Kulesskiy, L. Yetukuri, T. Laajala, Mukund Sharma, Karolina Pavic, Anna Aakula, C. Rupp, M. Jumppanen, P. Haapaniemi, Luyao Ruan, B. Yadav, Veronika Suni, Taru Varila, G. Corthals, J. Reimand, K. Wennerberg, T. Aittokallio, J. Westermarck   +19 more
semanticscholar   +1 more source

ER stress‐related ATF6 upregulates CIP2A and contributes to poor prognosis of colon cancer

Molecular Oncology, 2018
Endoplasmic reticulum (ER) stress is an adaptive response to various stress conditions and plays emerging roles in cancer. Activating transcription factor 6 (ATF6), one of the three major ER stress transducers, has been shown to contribute to ...
Chun‐Yu Liu, Chia‐Chi Hsu, Tzu‐Ting Huang, Chia‐Han Lee, Ji‐Lin Chen, Shung‐Haur Yang, Jeng‐Kai Jiang, Wei‐Shone Chen, Kuan‐Der Lee, Hao‐Wei Teng   +9 more
doaj   +1 more source

MTR4 drives liver tumorigenesis by promoting cancer metabolic switch through alternative splicing. [PDF]

, 2020
The metabolic switch from oxidative phosphorylation to glycolysis is required for tumorigenesis in order to provide cancer cells with energy and substrates of biosynthesis.
Chen, Wancheng, Dou, Wenlong, Feng, Bingbing, Fu, Xuemei, He, Yang-Fan, Ji, Kai-Yuan, Jiang, Lei, Kim, Jinchul, Li, Qingjiao, Mai, Taoyi, Tang, Qingshuang, Xiang, Le-Yang, XU, Yang, Yang, Dinghua, Ying, Yue, Yu, Lili, Zhou, Jianlong   +16 more
core   +1 more source

CBP loss cooperates with PTEN haploinsufficiency to drive prostate cancer: implications for epigenetic therapy [PDF]

, 2014
Despite the high incidence and mortality of prostate cancer, the etiology of this disease is not fully understood. In this study, we develop functional evidence for CBP and PTEN interaction in prostate cancer based on findings of their correlate ...
Chen, Shuai, Cheng, Liang, Cheville, John C., Ding, Liya, Huang, Haojie, Liu, Ping, Pan, Yunqian, Regan, Kevin M., Rizzardi, Tony, Schmechel, Stephen C., Tindall, Donald J., van Deursen, Jan, Wang, Liguo, Yu, Chunrong, Zhang, Jun, Zhong, Jian   +15 more
core   +1 more source

Deregulation of the phosphatase, PP2A is a common event in breast cancer, predicting sensitivity to FTY720 [PDF]

, 2014
We would like to thank Professor Andrew Hanby, Professor Valerie Speirs and Dr Thomas A Hughes for the breast cancer cell lines used in this study. This research was supported by the Faculty of Medicine and Surgery, University of Malta.Background: The
Baldacchino, Shawn, Borg, Nigel, Fenech, Anthony G., Grech, Godfrey, Petroni, Vanessa, Saliba, Christian   +5 more
core   +1 more source

X-linked Inhibitor of Apoptosis Protein (XIAP) Regulation of Cyclin D1 Protein Expression and Cancer Cell Anchorage-independent Growth via Its E3 Ligase-mediated Protein Phosphatase 2A/c-Jun Axis [PDF]

Journal of Biological Chemistry, 2013
The X-linked inhibitor of apoptosis protein (XIAP) is a well known potent inhibitor of apoptosis; however, it is also involved in other cancer cell biological behavior. In the current study, we discovered that XIAP and its E3 ligase played a crucial role in regulation of cyclin D1 expression in cancer cells.
Zipeng, Cao, Ruowen, Zhang, Jingxia, Li, Haishan, Huang, Dongyun, Zhang, Jingjie, Zhang, Jimin, Gao, Jingyuan, Chen, Chuanshu, Huang   +8 more
openaire   +2 more sources

CIP2A induces PKM2 tetramer formation and oxidative phosphorylation in non-small cell lung cancer

Cell Discovery
Tumor cells are usually considered defective in mitochondrial respiration, but human non-small cell lung cancer (NSCLC) tumor tissues are shown to have enhanced glucose oxidation relative to adjacent benign lung.
Li-Jun Liang, Fu-Ying Yang, Di Wang, Yan-Fei Zhang, Hong Yu, Zheng Wang, Bei-Bei Sun, Yu-Tao Liu, Gui-Zhen Wang, Guang-Biao Zhou   +9 more
doaj   +1 more source

PARP inhibition prevents escape from a telomere-driven crisis and inhibits cell immortalisation [PDF]

, 2018
Telomeric crisis is the final replicative barrier to cell immortalisation; it is characterised by genome instability and cell death and is triggered when telomeres become critically short and are subjected to fusion. Pre-cancerous lesions, or early stage
Argani, Ashworth, Ashworth, Bacchetti, Bacchetti, Bai, Baird, Baird, Baird, Baird, Baird, Baird, Baird, Baird, Bao, Burkle, Chang, Curtin, Dahm-Daphi, Dantzer, Dantzer, Dantzer, de Bono, de Lange, de Lange, de Lange, de Lange, De Marzo, DePinho, DePinho, Fegan, Fegan, Helleday, Helleday, Hendrickson, Iliakis, Jackson, Jackson, Karlseder, Lehtio, Lieber, Liu, Moroni, Ouellette, Pellat-Deceunynck, Pellicciari, Piwnica-Worms, Pommier, Pommier, Reddel, Robbins, Rottenberg, Salzer, Schuler, Schuler, Sfeir, Smith, Sugano, Weinberg, Wynford-Thomas, Zupi   +60 more
core   +3 more sources

Sex hormone-dependent tRNA halves enhance cell proliferation in breast and prostate cancers. [PDF]

, 2015
Sex hormones and their receptors play critical roles in the development and progression of the breast and prostate cancers. Here we report that a novel type of transfer RNA (tRNA)-derived small RNA, termed Sex HOrmone-dependent TRNA-derived RNAs (SHOT ...
Honda, Shozo, Imoto, Issei, Kirino, PhD, Yohei, Loher, Phillipe, Palazzo, Juan P., Rigoutsos, Isidore, Shigematsu, Megumi, Suzuki, Ryusuke   +7 more
core   +2 more sources