Results 81 to 90 of about 88,514 (261)

Thermo‐Chemically Modified Silk Scaffolds Reveal Niche‐Driven Regulation of Hematopoiesis and Fibrosis

Small, EarlyView.
We introduce a versatile 3D platform that recreates key physical and biological features of the human bone marrow. By integrating tunable silk biomaterials, stromal cells, and human hematopoietic progenitors, the model captures both healthy and diseased microenvironments, analysis of blood formation, and its disruption in pathological conditions ...
Christian A. Di Buduo, Carolina P. Miguel, Giulia Della Rosa, Vittorio Abbonante, Santo Diprima, Delfina Tosi, Marta Filibian, Daniele Cattaneo, Jugal Kishore Sahoo, Nicola Tirelli, Alessandra Iurlo, Umberto Gianelli, David L. Kaplan, Alessandra Balduini   +13 more
wiley   +1 more source

Avaliação da eficácia de um programa de intervenção multidisciplinar em sobreviventes de cancro da mama [PDF]

, 2015
Mestrado em Psicologia da Saúde e Reabilitação NeuropsicológicaCom os avanços que se têm alcançado na deteção precoce e no tratamento do cancro da mama tem-se verificado um aumento no número de sobreviventes de cancro da mama.
Correia, Tânia Alexandra Silva
core  

Glycogen Synthase Kinase 3 Regulates Cell Death and Survival Signaling in Tumor Cells under Redox Stress

Neoplasia: An International Journal for Oncology Research, 2014
Targeting tumor-specific metabolic adaptations is a promising anticancer strategy when tumor defense mechanisms are restrained. Here, we show that redox-modulating drugs including the retinoid N-(4-hydroxyphenyl)retinamide (4HPR), the synthetic ...
Roberta Venè, Barbara Cardinali, Giuseppe Arena, Nicoletta Ferrari, Roberto Benelli, Simona Minghelli, Alessandro Poggi, Douglas M. Noonan, Adriana Albini, Francesca Tosetti   +9 more
doaj   +1 more source

QoL de doentes com cancro do recto localmente avançado: QRT pré-operatória [PDF]

, 2013
O cancro colo-rectal é o terceiro tipo de cancro mais comum em ambos os sexos. Os factores ambientais, o sedentarismo, a obesidade, o tabagismo, o álcool, uma dieta rica em carne vermelha e pobre em fibras, desempenham um forte papel na etiologia do ...
Coelho, Carina Marques, Farinha, Camila, Monsanto, Fátima, Moreira, Ana Catarina, Sá, Ana Cravo   +4 more
core  

Unusual Disease‐Progression in Two Siblings With Xeroderma Pigmentosum Group G

Clinical Genetics, EarlyView.
Protein truncation mutations in the gene for XPG nuclease cause a very severe clinical phenotype. Two siblings have splicing mutations, which result in in‐frame deletions and a less severe phenotype.
Elena Botta, Heather Fawcett, Donata Orioli, Hiva Fassihi, Alan R. Lehmann   +4 more
wiley   +1 more source

Extensive colectomy in colorectal cancer and hereditary nonpolyposis colorectal cancer – long-term results

Journal of Coloproctology, 2019
Background: Colorectal cancer survival is better in hereditary nonpolyposis colorectal cancer patients than in sporadic colorectal cancer patients and even for hereditary nonpolyposis colorectal cancer with colorectal cancer is not consensual that ...
Marisa D. Santos, Cláudio Silva, João Oliveira, Pedro Brandão, Mónica Sampaio, Ana Cristina Silva, Anabela Rocha, Eduarda Matos, Ricardo Marcos-Pinto   +8 more
doaj   +1 more source

Physical exercise and breast cancer: a review [PDF]

, 2012
Introdução – Os efeitos fisiológicos da atividade física e do treino são atualmente motivo de extensa investigação cujos resultados mostraram já de forma incontroversa os seus benefícios em diferentes condições clínicas.
Fernandes, Beatriz, Tomás, Maria Teresa
core  

Behind the scenes: how the EMILIN/Multimerin family shapes the cancer landscape

The FEBS Journal, EarlyView.
The EMILIN/Multimerin family members regulate key hallmarks of cancer—including apoptosis, angiogenesis, metastasis, and tumor microenvironment remodeling. As indicated, their function in immune evasion, drug resistance, and metabolic reprogramming remains largely unexplored.
Evelina Poletto, Naike Casagrande, Emanuele Di Siena, Greta Carobolante, Lucrezia Camicia, Giorgia Schinello, Samanta Muzzin, Enrica Timis, Paola Spessotto, Maurizio Mongiat   +9 more
wiley   +1 more source

Quando a Doença Rouba a Meninice... [PDF]

, 2004
p. 59-64O desenvolvimento de formas de atendimento em Portugal à criança vítima de cancro constitui a principal motivação do presente trabalho. Comparando com as iniciativas realizadas no estrangeiro, pretendemos divulgar tipologias de serviços ...
Soares, Carla Elizabeth Gonçalves, Sousa, Júlio Emílio Pereira de   +1 more
core  

ER proteostasis meets mitochondrial function: contact sites as hubs of communication and therapeutic targets

The FEBS Journal, EarlyView.
Proteostasis ensures proper protein folding, modification, and degradation, while its impairment triggers ER stress. Chronic ER stress and maladaptive UPR via the CHOP–ERO1 axis remodel ERMCs, altering calcium signaling and mitochondrial metabolism.
Giorgia Maria Renna, Alessandro Cherubini, Ersilia Varone, Serena Germani, Alice Marrazza, Ester Zito   +5 more
wiley   +1 more source