Results 61 to 70 of about 34,996 (233)

ER proteostasis meets mitochondrial function: contact sites as hubs of communication and therapeutic targets

The FEBS Journal, EarlyView.
Proteostasis ensures proper protein folding, modification, and degradation, while its impairment triggers ER stress. Chronic ER stress and maladaptive UPR via the CHOP–ERO1 axis remodel ERMCs, altering calcium signaling and mitochondrial metabolism.
Giorgia Maria Renna, Alessandro Cherubini, Ersilia Varone, Serena Germani, Alice Marrazza, Ester Zito   +5 more
wiley   +1 more source

Pattern‐based interpretation of SOX2 expression in ovarian teratomas: avoiding diagnostic pitfalls in the distinction between immature and mature neuroectodermal elements

Histopathology, EarlyView.
Ovarian immature teratoma grading may be confounded by mature neuroectodermal mimics. SOX2 labelled immature neuroepithelium but also mature ependymal and glial tissue, while SALL4 was negative in mature mimics and variably expressed in immature neuroepithelium.
Agnese Orsatti, Caterina Ravaioli, Marco Grillini, Eugenia Franchini, João Lobo, Andres M. Acosta, Veronica Mollica, Claudio Zamagni, Pierandrea De Iaco, Anna Myriam Perrone, Michelangelo Fiorentino, Giovanni Tallini, W. Glenn McCluggage, Costantino Ricci, Antonio De Leo   +14 more
wiley   +1 more source

Glycogen Synthase Kinase 3 Regulates Cell Death and Survival Signaling in Tumor Cells under Redox Stress

Neoplasia: An International Journal for Oncology Research, 2014
Targeting tumor-specific metabolic adaptations is a promising anticancer strategy when tumor defense mechanisms are restrained. Here, we show that redox-modulating drugs including the retinoid N-(4-hydroxyphenyl)retinamide (4HPR), the synthetic ...
Roberta Venè, Barbara Cardinali, Giuseppe Arena, Nicoletta Ferrari, Roberto Benelli, Simona Minghelli, Alessandro Poggi, Douglas M. Noonan, Adriana Albini, Francesca Tosetti   +9 more
doaj   +1 more source

Cancro mole

Jornal Brasileiro de Doenças Sexulamente Transmissíveis, 1989
Moléstia com características de ulceração dolorosa, aguda, irregular, contagiosa, auto-inoculável, específica, geralmente localizada na genitália externa: podendo também ser encontrada no ânus. Por vezes, apresenta adenopatia inguinal de aspecto supurativo, denominada bubão. [...]
openaire   +2 more sources

Extensive colectomy in colorectal cancer and hereditary nonpolyposis colorectal cancer – long-term results

Journal of Coloproctology, 2019
Background: Colorectal cancer survival is better in hereditary nonpolyposis colorectal cancer patients than in sporadic colorectal cancer patients and even for hereditary nonpolyposis colorectal cancer with colorectal cancer is not consensual that ...
Marisa D. Santos, Cláudio Silva, João Oliveira, Pedro Brandão, Mónica Sampaio, Ana Cristina Silva, Anabela Rocha, Eduarda Matos, Ricardo Marcos-Pinto   +8 more
doaj   +1 more source

Adenine nucleotide translocator and ATP synthase cooperate in mediating the mitochondrial permeability transition

The Journal of Physiology, EarlyView.
Abstract figure legend Both ATP synthase and adenine nucleotide translocator (ANT) play key roles in mediating the permeability transition. The contribution of ANT becomes evident in the presence of atractylate (ATR) at pH 6.5, a condition that prevents ATP synthase channel activity. At pH 7.4, this effect is minimal, suggesting a critical role for ATP
Ludovica Tommasin, Andrea Carrer, Federica Boscolo Nata, Elena Frigo, Federico Fogolari, Giovanna Lippe, Michela Carraro, Paolo Bernardi   +7 more
wiley   +1 more source

Voltage‐gated potassium channels mediate thyroid hormone control of skeletal muscle excitability

The Journal of Physiology, EarlyView.
Abstract figure legend Thyroid hormone (TH)‐dependent remodelling of potassium (K+) channel networks regulates skeletal muscle (SkM) excitability. Triiodothyronine (T3), locally generated from thyroxine (T4) by type 2 deiodinase (D2), binds thyroid hormone receptors (TRα/β) and modulates transcription via thyroid response elements (TREs).
Annarita Nappi, Caterina Miro, Annunziata Gaetana Cicatiello, Ilaria Piccialli, Serena Sagliocchi, Lucia Acampora, Federica Restolfer, Rosa Sirica, Melania Murolo, Emery Di Cicco, Daniela Terracciano, Anna Pannaccione, Monica Dentice   +12 more
wiley   +1 more source

Determinação da atividade anti tumoral de derivados quirais de xantonas

RevSALUS, 2022
João Sousa, Flávia Barbosa, Andrea Cunha, Maria Elizabeth Tiritan, Odília Queirós   +4 more
doaj   +1 more source

Melanoma maligno: estudo comparativo entre o nível de conhecimentos e comportamentos preventivos nos alunos do 9º ano da área do Centro de Saúde de São João

Revista Portuguesa de Medicina Geral e Familiar, 2002
Objectivos: Caracterizar os comportamentos relacionados com a exposição solar e o nível de conhecimentos sobre melanoma maligno nos alunos do 9º ano de escolaridade da área do Centro de Saúde de São João; verificar se existe associação entre ...
Paula Mourão
doaj   +1 more source

Resource‐Adapted Triage Strategies for Women Testing HPV Positive With Self‐Collected Vaginal Samples in Cameroon

International Journal of Cancer, Volume 159, Issue 8, Page 1949-1961, 15 October 2026.
Although human papillomavirus (HPV) testing is recommended for cervical cancer screening in low‐ and middle‐income countries, optimal management of HPV‐positive women remains undetermined, particularly in resource‐limited settings. Here, using data from the 3T study involving women in Cameroon, the authors evaluated the ability of extended HPV ...
Micol Murtas, Pierre Vassilakos, Ania Wisniak, Ketty Hu, Marc Arbyn, Gilles W. Tankeu Happi, Esther Abatsong, François Marcel Ndam Nsangou, Jean‐Christophe Tille, Essia Saiji, Bruno Kenfack, Patrick Petignat   +11 more
wiley   +1 more source