Results 81 to 90 of about 46,556 (258)

Structural dynamics and pH‐regulated membrane binding of the TRAF2‐NC trimer

open access: yesProtein Science, Volume 35, Issue 11, November 2026.
Abstract Tumor necrosis factor receptor‐associated factor 2 (TRAF2) is a key adaptor in TNF receptor‐signaling that operates as a trimeric assembly. Here we investigate the structural and functional properties of a TRAF2 construct spanning the trimerization and receptor‐binding domains (TRAF2‐NC, residues 266–501).
Federica Cossu   +9 more
wiley   +1 more source

Glycogen Synthase Kinase 3 Regulates Cell Death and Survival Signaling in Tumor Cells under Redox Stress

open access: yesNeoplasia: An International Journal for Oncology Research, 2014
Targeting tumor-specific metabolic adaptations is a promising anticancer strategy when tumor defense mechanisms are restrained. Here, we show that redox-modulating drugs including the retinoid N-(4-hydroxyphenyl)retinamide (4HPR), the synthetic ...
Roberta Venè   +9 more
doaj   +1 more source

A Evidência da Mamografia de Rastreio na Diminuição da Mortalidade por Cancro da Mama: Uma Revisão Sistemática

open access: yesGazeta Médica, 2018
INTRODUÇÃO: O rastreio do cancro da mama é realizado através da mamografia nas mulheres. O objetivo desta revisão foi avaliar se a mamografia de rastreio diminui a mortalidade por cancro da mama.
S. Alves, Bernardo Pereira, I. Peixoto
semanticscholar   +1 more source

Resource‐Adapted Triage Strategies for Women Testing HPV Positive With Self‐Collected Vaginal Samples in Cameroon

open access: yesInternational Journal of Cancer, Volume 159, Issue 8, Page 1949-1961, 15 October 2026.
Although human papillomavirus (HPV) testing is recommended for cervical cancer screening in low‐ and middle‐income countries, optimal management of HPV‐positive women remains undetermined, particularly in resource‐limited settings. Here, using data from the 3T study involving women in Cameroon, the authors evaluated the ability of extended HPV ...
Micol Murtas   +11 more
wiley   +1 more source

Extensive colectomy in colorectal cancer and hereditary nonpolyposis colorectal cancer – long-term results

open access: yesJournal of Coloproctology, 2019
Background: Colorectal cancer survival is better in hereditary nonpolyposis colorectal cancer patients than in sporadic colorectal cancer patients and even for hereditary nonpolyposis colorectal cancer with colorectal cancer is not consensual that ...
Marisa D. Santos   +8 more
doaj   +1 more source

Characterization of the Interaction of Known G‐quadruplex Ligands With a Minimal i‐Motif Structure

open access: yesChemistry – A European Journal, Volume 32, Issue 37, 1 October 2026.
The destabilization of a minimal i‐Motif (iM) structure by TMPyP4 is driven by ligand recognition of one terminal iM structural domain. ABSTRACT Peculiar genomic regions are prone to evolve transiently from double‐helix DNA to noncanonical secondary structures in response to physiological stress.
Davide Auricchio   +3 more
wiley   +1 more source

Destaques da ASCO 2016 - Imunoterapia no Tratamento do Cancro do Pulmão | Rastreio do Cancro do Pulmão: Considerações Lógicas e Práticas

open access: yesGazeta Médica, 2018
Inibidores de immune checkpoint são uma promessa na luta contra o cancro do pulmão e outros tumores malignos, alterando o microambiente do tumor e bloqueando a evasão ao sistema imunitário.
Maria Bárbara Parente
doaj   +1 more source

Turnaround Time Trends in Cervical Cytology Screening in South Africa, 2005–2023

open access: yesDiagnostic Cytopathology, Volume 54, Issue 10, Page 755-763, October 2026.
ABSTRACT Background Timely cervical cytology results are crucial for effective screening and early management of precancerous lesions. However, many low‐ and middle‐income countries face delays in turnaround time (TAT). This study assessed TAT for cytology screening results in South Africa from 2005 to 2023 and identified factors associated with TAT ...
Sizeka Mashele   +8 more
wiley   +1 more source

Ameixeira (Prunus domestica L.): cancro bacteriano [Fruto]

open access: yes, 2014
Apresenta o cancro bacteriano em frutos da ameixeiraComponente Curricular::Educação Superior::Ciências Agrárias ...
Del Ponte, Emerson Medeiros
core  

Determinação da atividade anti tumoral de derivados quirais de xantonas

open access: yesRevSALUS, 2022
João Sousa   +4 more
doaj   +1 more source

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