Results 41 to 50 of about 84,076 (240)

Switching circuits with fast response and low power drain [PDF]

, 1970
New logic circuits have response times no longer than 10 nanoseconds and drain only milliwatts of power. The family includes AND and NAND gates and forms the basis of all logic functions.
Cancro, C. A.
core   +1 more source

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

Wide range data compression system Patent [PDF]

, 1970
Wide range analog data compression ...
Cancro, C. A.
core   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

Obstipação induzida pelos opióides em doentes oncológicos adultos

Onco.News, 2017
Os opióides são o gold-standard para o tratamento da dor oncológica, mas alguns dos seus efeitos adversos podem comprometer o seu potencial terapêutico, como é o caso da obstipação.
Daniela Dias, Juliana Santos, Carina Raposo, Luís Batalha, Ana Leonor Ribeiro, Ana Cristina Ferreira   +5 more
doaj   +1 more source

Condicionantes da adaptação das famílias enquanto sistema e cliente face à situação de cancro: Scoping review

Revista de Enfermagem Referência, 2021
Contexto: O cancro está associado a perda e ameaça à vida, pelo que o seu diagnóstico configura carga emocional, tensão e sofrimento psicológico dos indivíduos e famílias, mediados por múltiplos fatores condicionantes dos processos adaptativos ...
Carla Alexandra Santos, Katia Sophie Ribeiro da Costa, Maria Jacinta Dantas, Carminda Morais   +3 more
doaj   +1 more source

Passive synchronized spike generator with high input impedance and low output impedance and capacitor power supply Patent [PDF]

, 1968
Pulse generator for synchronizing or resetting electronic signals without requiring separate external ...
Cancro, C. A., Janniche, P. J., Jr.
core   +1 more source

The cooperative regulation of miR‐221 by APE1 and AUF1 impacts p27Kip1 defining a miR signature relevant for cervical cancer

FEBS Open Bio, EarlyView.
A regulatory axis involving APE1, AUF1, and miR‐221 is proposed. Pri‐miR‐221 is processed by DROSHA and DICER to generate mature miR‐221, which targets p27Kip1 mRNA. APE1 and AUF1 compete for pre‐miR‐221 binding. Reduced APE1/AUF1 levels impair miR‐221 biogenesis, decrease p27Kip1 mRNA degradation, and promote cell cycle progression, chemoresistance ...
Matilde Clarissa Malfatti, Nicolò Gualandi, Gianluca Tell, Giulia Antoniali   +3 more
wiley   +1 more source

COMPLETE RESPONSE OF CUTANEOUS METASTASIS IN A MELANOMA PATIENT TREATED WITH IPILIMUMAB. [PDF]

Euromediterranean Biomedical Journal, 2012
We present the case of a 58 year old woman, who achieved complete response for her cutaneous melanoma metastasis after treatment with ipilimumab at 3 mg/Kg.
Francesco Spagnolo, Serena Savaia, Marco Grosso, Paola Queirolo   +3 more
doaj   +1 more source

Synchronized pulse generator needs no external power [PDF]

, 1965
Simple circuit with high input and low output impedance generates a fast rise-time pulse synchronized with an input pulse of slower rise and fall times.
Cancro, C. A., Janniche, P. J., Jr.
core   +1 more source