Results 51 to 60 of about 408,199 (364)

Biocatalytic Regioselective C‐Formylation of Resorcinol Derivatives

Angewandte Chemie, EarlyView.
An acyltransferase from Chromobacterium sphagni (CsATase) was identified that catalyzes the regioselective formylation of resorcinol substrates. The formylation of substituted resorcinol derivatives yielded mono‐formylated products with up to 99% conversion and up to 74% isolated yield.
Lilla Gal, Suresh Rohan, Anna Żądło‐Dobrowolska, Bianca Hilweg, Judith Müller, Kai Tittmann, Wolfgang Kroutil   +6 more
wiley   +2 more sources

Evaluation of effect the cyclic lipopeptides from Bacillus atrophaeus HNSQJYH170 on Candida species

Majallah-i Dānishgāh-i ̒Ulūm-i Pizishkī-i Qum, 2018
Background and Objectives: In humans, during the recent years, several factors have increased the risk of fungal infections, like broad spectrum antibiotics, immune compromised patients, cytotoxic chemotherapy and transplantations.
Solmaz Moghtadi pisheh, Mahboobeh madani
doaj  

Gut microbiota of HIV-infected patients with multidrug-resistant tuberculosis

Фундаментальная и клиническая медицина, 2022
Aim. To determine the composition and properties of the gut microbiota in HIV-infected patients with pulmonary tuberculosis.Materials and Methods. We studied 92 faecal samples from patients with pulmonary tuberculosis (n = 46) and patients with combined ...
L. Yu. Otdushkina, Yu. V. Zakharova, A. A. Kholodov, L. A. Levanova, T. V. Pyanzova, A. A. Markovskaya   +5 more
doaj   +1 more source

First hospital outbreak of the globally emerging Candida auris in a European hospital

Antimicrobial Resistance and Infection Control, 2016
Candida auris is a globally emerging multidrug resistant fungal pathogen causing nosocomial transmission. We report an ongoing outbreak of C. auris in a London cardio-thoracic center between April 2015 and July 2016. This is the first report of C.
S. Schelenz, F. Hagen, J. Rhodes, A. Abdolrasouli, A. Chowdhary, A. Hall, Lisa Ryan, Joanne Shackleton, R. Trimlett, J. Meis, D. Armstrong-James, Matthew Fisher   +11 more
semanticscholar   +1 more source

A Deep Representation Learning Method for Quantitative Immune Defense Function Evaluation and Its Clinical Applications

Advanced Science, EarlyView.
ImmuDef, a novel algorithm to quantitatively evaluate the anti‐infection immune defense function of an individual based on RNA‐seq data via a variational autoencoder (VAE) model. It is validated on 3200+ samples across four immune states with high accuracy. It can serve as a metric for disease severity and prognosis across pathogenic cohorts.
Zhen‐Lin Tan, Tao Luo, Yu Lin, Xiao‐Jun Wu, Wen‐Kang Shen, Jie Chen, Qian Lei, An‐Yuan Guo   +7 more
wiley   +1 more source

Genomic insights into multidrug-resistance, mating and virulence in Candida auris and related emerging species

Nature Communications, 2018
Candida auris is an emergent multidrug-resistant fungal pathogen causing increasing reports of outbreaks. While distantly related to C. albicans and C. glabrata, C.
J. Muñoz, L. Gade, N. Chow, V. Loparev, Phalasy Juieng, E. Berkow, Rhys A. Farrer, A. Litvintseva, Christina A. Cuomo   +8 more
semanticscholar   +1 more source

Distribution and Antifungal Susceptibility of Candida Species Causing Candidemia in China: An Update From the CHIF-NET Study.

Journal of Infectious Diseases, 2020
BACKGROUND Candidemia is the most common, serious fungal infection and Candida antifungal resistance is a challenge. We report recent surveillance of candidemia in China. METHODS The study encompassed 77 Chinese hospitals over 3 years.
M. Xiao, S. Chen, F. Kong, Xiu-li Xu, Li Yan, H. Kong, Xin Fan, X. Hou, Jing-wei Cheng, Menglan Zhou, Ying-xing Li, Shu-ying Yu, Jing-jing Huang, Ge Zhang, Yang Yang, Jingjia Zhang, S. Duan, W. Kang, He Wang, Yingchun Xu   +19 more
semanticscholar   +1 more source

CACLENS: A Multitask Deep Learning System for Enzyme Discovery

Advanced Science, EarlyView.
CACLENS, a multimodal and multi‐task deep learning framework integrating cross‐attention, contrastive learning, and customized gate control, enables reaction type classification, EC number prediction, and reaction feasibility assessment. CACLENS accelerates functional enzyme discovery and identifies efficient Zearalenone (ZEN)‐degrading enzymes.
Xilong Yi, Yingzhu Tan, Huikang Lin, Guoqing Zhang, Ye Tian, Aibo Wu   +5 more
wiley   +1 more source

High Incidence of Candidemia in Critically Ill COVID-19 Patients Supported by Veno-Venous Extracorporeal Membrane Oxygenation: A Retrospective Study

Journal of Fungi, 2023
Background: The incidence of candidemia in severe COVID-19 patients (0.8–14%) is two- to ten-fold higher than in non-COVID-19 patients. Methods: This retrospective analysis aimed to analyse the incidence of bloodstream infections (BSI) due to Candida in ...
Francesco Alessandri, Giancarlo Ceccarelli, Giuseppe Migliara, Valentina Baccolini, Alessandro Russo, Carolina Marzuillo, Mariateresa Ceparano, Giovanni Giordano, Pierfrancesco Tozzi, Gioacchini Galardo, Giammarco Raponi, Claudio Mastroianni, Mario Venditti, Francesco Pugliese, Gabriella d’Ettorre   +14 more
doaj   +1 more source

Postantifungal effect of anidulafungin against Candida albicans, Candida dubliniensis, Candida africana, Candida parapsilosis, Candida metapsilosis and Candida orthopsilosis.

Revista espanola de quimioterapia : publicacion oficial de la Sociedad Espanola de Quimioterapia, 2019
Candida albicans remains the most common aetiology of invasive candidiasis, leading to high morbidity and mortality. Nevertheless, the incidence of candidiasis due to non-C. albicans species, such as Candida parapsilosis, is increasing. Postantifungal effect (PAFE) is relevant for establishing dosage schedules in antifungal therapy, as the frequency of
S, Gil-Alonso, G, Quindós, E, Eraso, N, Jauregizar   +3 more
openaire   +1 more source