Results 91 to 100 of about 204,330 (266)

Host‐Directed Biomaterials for Combatting Bloodstream Infections: From Macrocyclic Peptides to Immune‐Activating Cell Backpacks

Advanced Functional Materials, Volume 36, Issue 24, 23 March 2026.
Bloodstream infections (BSI) are one of the leading causes of mortality and morbidity in both civilian and military populations. This paper summarizes recent progress in novel treatment strategies to manage BSI arising from both bacterial and fungal pathogens using molecules, particles, and materials to elicit host‐directed immunity.
Thomas Thomou, Jagadish Krishnappa, Justin B. Schaal, Prasad Tongaonkar, Dat Q. Tran, Wenchao Gu, Yung‐Fu Chang, Michael E. Selsted, Shaoyi Jiang, Samir Mitragotri, Michael Super, Christopher J. Bettinger   +11 more
wiley   +1 more source

CsdA‐LaeB Regulatory Hub Contributes to Aspergillus fumigatus Virulence via Fumiquinazoline C Biosynthesis

Advanced Science, Volume 13, Issue 16, 18 March 2026.
This study identifies a conserved CsdA‐LaeB hub in Aspergillus fumigatus that regulates secondary metabolite fumiquinazoline C (FqC). Disrupting this hub enhances FqC production and virulence, shedding new light on the post‐transcriptional regulatory logic linking secondary metabolism to pathogenicity and offering alternative strategies for diagnostic ...
Zili Song, Hongjiao Zhang, Leixin Ye, Yuxin Lei, Linqi Wang, Xiao Liu, Nayanna M. Mercado Soto, Nancy P. Keller, Berl R. Oakley, Can Zhao, Michael Bromley, Hongwei Liu, Lei Cai, Koon Ho Wong, Wen‐Bing Yin   +14 more
wiley   +1 more source

Candida auris: Epidemiology, biology, antifungal resistance, and virulence.

PLoS Pathogens, 2020
First described in 2009 in Japan, the emerging multidrug-resistant fungal pathogen Candida auris is becoming a worldwide public health threat that has been attracting considerable attention due to its rapid and widespread emergence over the past decade ...
Han Du, Jian Bing, Tianren Hu, Craig L Ennis, Clarissa J Nobile, Guanghua Huang   +5 more
doaj   +1 more source

Candida auris Outbreaks: Current Status and Future Perspectives

Microorganisms
Candida auris has been identified by the World Health Organization (WHO) as a critical priority pathogen on its latest list of fungi. C. auris infections are reported in the bloodstream and less commonly in the cerebrospinal fluid and abdomen, with ...
Silvia De Gaetano, A. Midiri, Giuseppe Mancuso, Maria Giovanna Avola, C. Biondo   +4 more
semanticscholar   +1 more source

Mortality Caused by Candida auris Bloodstream Infections in Comparison with Other Candida Species, a Multicentre Retrospective Cohort

Journal of Fungi, 2023
Candida auris is an emerging pathogen considered to be critical in the World Health Organization fungal organisms list. The study aims to determine the mortality and hospital stays attributed to Candida auris (C.
Cynthia Ortiz-Roa, Martha Carolina Valderrama-Rios, Sebastián Felipe Sierra-Umaña, José Yesid Rodríguez, Gerardo Antonio Muñetón-López, Carlos Augusto Solórzano-Ramos, Patricia Escandón, Carlos Arturo Alvarez-Moreno, Jorge Alberto Cortés   +8 more
doaj   +1 more source

First report of sporadic cases of Candida auris in Colombia

International Journal of Infectious Diseases, 2018
Background: Candida auris is a recently reported Candida species that is phenotypically similar to Candida haemulonii and related to hospital outbreaks.
Claudia M. Parra-Giraldo, Sandra L. Valderrama, Gloria Cortes-Fraile, Javier R. Garzón, Beatriz E. Ariza, Florent Morio, Melva Y. Linares-Linares, Andrés Ceballos-Garzón, Alejandro de la Hoz, Catalina Hernandez, Carlos Alvarez-Moreno, Patrice Le Pape   +11 more
doaj   +1 more source

Candida auris en Chile [PDF]

Boletín Micológico, 2019
C. auris es una levadura que debe preocupar a todos los clínicos y laboratorios de los distintos recintos hospitalarios del país, debido a las dificultades que presenta para poder identificarla y por la resistencia a las principales familias de antifúngicos de uso habitual.
openaire   +1 more source

Candida auris—a systematic review to inform the world health organization fungal priority pathogens list

Medical Mycology
The World Health Organization (WHO) in 2022 developed a fungal priority pathogen list. Candida auris was ultimately ranked as a critical priority pathogen.
PhD Hannah Yejin Kim, MSc Thi Anh Nguyen, PhD Sarah Kidd, MD Joshua Chambers, PhD Ana Alastrue y-Izquier do, MD Jong-Hee Shin, PhD Aiken Dao, MD Agustina Forastiero, MD Retno Wahyuningsih, MD Arunoloke Chakr abar ti, P. Be, 11 er, Valeria Gig, PhD Justin Bear dsle y, PhD Hatim Sati, C. Or, PhD la Mor r isse y, PhD J an-Willem Alffenaar, PhD Jan-Willem Alffenaar   +18 more
semanticscholar   +1 more source

Biofilm Associated Persistence and Drug Tolerance in Mycobacteria Within Host Microenvironments

APMIS, Volume 134, Issue 3, March 2026.
ABSTRACT Biofilms formed by mycobacteria, particularly Mycobacterium tuberculosis (Mtb), represent a major challenge in tuberculosis (TB) treatment due to their highly organized structure and their capacity to induce phenotypic drug tolerance. These three‐dimensional bacterial aggregates are embedded in a self‐produced extracellular matrix that ...
Lourdes Serrano Garcia, Cesar Augusto Roque‐Borda, Fernando Rogério Pavan, Marlus Chorilli   +3 more
wiley   +1 more source

Rapid evolution of an adaptive multicellular morphology of Candida auris during systemic infection

Nature Communications
Candida auris has become a serious threat to public health. The mechanisms of how this fungal pathogen adapts to the mammalian host are poorly understood. Here we report the rapid evolution of an adaptive C.
Jian Bing, Zhangyue Guan, Tianhong Zheng, Craig L Ennis, C. Nobile, Changbin Chen, Haiqing Chu, Guanghua Huang   +7 more
semanticscholar   +1 more source