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Targeting Candida spp. to develop antifungal agents
Drug Discovery Today, 2018Invasive fungal infections are a complex challenge throughout the world because of their high incidence, mainly in critically ill patients, and high mortality rates. The antifungal agents currently available are limited; thus, there is a need for the rapid development of new drugs. In silico methods are a modern strategy to explore interactions between
Tânia P, Salci +4 more
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Investigation of Candida dubliniensis in Candida spp.‐positive hemocultures
APMIS, 2002Candida dubliniensis is one of the Candida species which was first recognized in 1995. The yeast was misidentified because of its phenotypic similarities with Candida albicans. In this study, blood samples of patients from various departments at Ankara University Medical Faculty between January ...
Istar, Dolapci +4 more
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Journal of Molecular Evolution, 1996
Codon CUG is used for serine instead of for leucine, its usual assignment, in several yeasts of the genus Candida. We propose a series of steps for the reassignment, including disappearance of leucine CUG and its anticodon CAG, formation of a new serine tRNA, with anticodon CAG, from a duplication of the gene for serine tRNA (IGA), and then production ...
T H, Jukes, S, Osawa
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Codon CUG is used for serine instead of for leucine, its usual assignment, in several yeasts of the genus Candida. We propose a series of steps for the reassignment, including disappearance of leucine CUG and its anticodon CAG, formation of a new serine tRNA, with anticodon CAG, from a duplication of the gene for serine tRNA (IGA), and then production ...
T H, Jukes, S, Osawa
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Studies on the nucleus of candida spp
Mycopathologia, 1959Nuclear division inCandida albicans during budding and blastospore formation is described. Classic mitotic division as it occurs in the higher ascomycetes is not seen. Instead, the semi-lunar (crescentic) chromatinic material in the nucleus increases so as to fill the nuclear vesicle, often assuming a toroid-like aspect.
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Emerging Candida spp. Infections
2003More than 150 species of Candida have been idenfified, but only a dosen or so have been regarded as important pathogens in humans. Although C. albicans remains the most common fungal pathogen, over the past decade or so, there has been an increasing number of reports implicating non-albicans species causing opportunistic mycoses (1).
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Phospholipase Activity in Candida Albicans, Candida Spp and Other Yeasts
1991The ability of Candida albicansto produce cytolytic enzymes such as proteinases 1,2 and phospholipases 3,4 may be associated with the pathogenicity of this fungus 5. The phospholipases secreted by C. albicanscould play a part in the invasion of the host tissues in lesions of candidosis 6 by disrupting the epithelial cell membranes and allowing the ...
A. Rezusta +4 more
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Examination on Candida spp. in refractory periapical granulomas
International Endodontic Journal, 2003AbstractAim To examine the occurrence of Candida spp. in refractory periapical granulomas.Methodology One hundred and three surgically removed periapical granulomas were subjected to molecular analysis for the occurrence of Candida albicans. DNA was extracted from the samples using a modified phenol/chloroform/isoamyl alcohol method and was subjected
Waltimo, Tuomas +7 more
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Immunological Features Protect Against Candida spp.
2015The epithelial mucosa is an important component of the host immune defense and immune surveillance since it is the first layer that most microorganisms initially contact. The most important function of the immune system is to discriminate between self and nonself, a property that is essential for the maintenance of immune homeostasis.
Spolidorio, Denise M. Palomari +3 more
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