Results 51 to 60 of about 18,942 (189)

Effects of the HDAC6/8 Inhibitor MC1568, Alone and in Combination With Fluconazole, in Non‐Albicans Candida Species Infections

MicrobiologyOpen, Volume 15, Issue 4, August 2026.
This study explores new antifungal strategies to combat non‐albicans Candida species. We tested clinically approved HDAC inhibitors—Vorinostat, Romidepsin, Tucidinostat—and the HDAC6/8‐selective MC1568, alone and with Fluconazole. The Fluconazole/MC1568 combination significantly enhanced antifungal activity and reduced biofilm formation.
Andrea Giammarino, Chiara Lambona, Alessia Raucci, Giovanna Simonetti, Salvatore Macrì, Angela Iuzzolino, Daniela Trisciuoglio, Sergio Valente, Gustavo Giusiano, Letizia Angiolella, Antonello Mai   +10 more
wiley   +1 more source

From Oral Candidiasis to Candidemia: A Review of Superficial to Invasive Progression

MicrobiologyOpen, Volume 15, Issue 4, August 2026.
Recent and limited evidence indicates that oral candidiasis can disseminate Candida albicans throughout the body, leading to invasive candidiasis, such as candidemia, a life‐threatening infection. Considering antifungal resistance and global outbreaks of emergent non‐albicans Candida and related yeasts, murine models help understand dissemination ...
Julia Robledo Jerez, Marcella Vieira Ambrosio, Marcela Eduarda Olegario Fernandes, Ewerton Garcia de Oliveira Mima   +3 more
wiley   +1 more source

Gut Mycobiota‐Associated Tryptophan Catabolites Protect Against Metabolic Dysfunction‐Associated Steatotic Liver Disease

Advanced Science, Volume 13, Issue 39, 13 July 2026.
ABSTRACT Accumulating evidence suggests that the intestinal microbiota participates in the progression of metabolic dysfunction‐associated steatotic liver disease (MASLD) through microbiota‐host interaction. However, the beneficial role of commensal mycobiota in MASLD progression remains poorly understood.
Shuping Qiao, Shuangya Fan, Juan Xu, Zhen Xu, Chen Peng, Junxing Qu, Ziqian Bing, Shizhen Zhou, Sunan Shen, Guifang Xu, Yue Zhao, Tingting Wang   +11 more
wiley   +1 more source

In Vitro Synergism Effect of an Aqueous Garlic Extracts against Six Commonly Clinical Isolated Candida Species [PDF]

Iranian Journal of Public Health, 2007
Background: The growth of different microorganisms including bacteria, fungi and viruses has been inhibited by garlic extracts in many studies. The antifungal activity of aqueous garlic extract was investigated in an in vitro system using broth ...
A A Jafari, A Fatahi Bafghi, MH Anvari, H Zarrinfar   +3 more
doaj   +1 more source

Prevalência de Candida spp. em biofilme dentário de usuários de aparelhos ortodônticos fixos

Revista da Faculdade de Odontologia de Porto Alegre, 2012
OBJETIVOS: O presente estudo tem como objetivo avaliar a prevalência de Candida spp. em biofilme dentário de usuários de aparelhos ortodônticos fixos (AOF) e relacionar com seus hábitos e características.
Michele Mezzari, Amanda Gomes Faria, Igor Palagi de Souza, Ernani Marchioro, Alexandre Meneghello Fuentefria, Adelina Mezzari   +5 more
doaj   +1 more source

Crystal Facet‐Polysaccharide Matching in CFS‐P Nanocrystals Drives Fungal Uptake, Vacuole Destruction, and Selective Antifungal Activity

Advanced Science, Volume 13, Issue 39, 13 July 2026.
Facet‐engineered PVP‐capped CuFeSe2 nanocrystals exhibit potent, selective antifungal activity by strongly binding cell‐wall mannan, enabling vacuolar entry and organelle disruption. High‐index facets show superior mannan affinity, validated by theoretical calculations and experiments. CFS‐P induces vacuolar cavitation, mitochondrial abnormalities, and
Zhaohui Wang, Xiaojin Deng, Xujuan Huang, Yuhang Pan, Yao Qin, Lu Zhang, Le Xu, Tianyi Qin, Deteng Zhang, Yi Ma, Yalong Wang   +10 more
wiley   +1 more source

A Cationic Supramolecule With Potent Antifungal Activity, Single‐Species Selectivity, and Strong Synergy With Echinocandins

Advanced Science, Volume 13, Issue 41, 22 July 2026.
We introduce a new membrane‐active antifungal design, Gua‐SMACS‐16, that exhibits high potency and single‐species selectivity for C. tropicalis while sparing other close species in the Candida genus. Moreover, when combining with caspofungin, a clinical antifungal drug inhibiting 1,3‐β‐glucan synthase, they exhibit ultra‐strong synergy across a panel ...
Tianjiao Dai, Adrielle Xianwen Chen, Eve Wai Ling Chow, Li Mei Pang, Jianguo Li, Chandra Shekhar Verma, Stefan H. Oehlers, Yue Wang, Ning Li   +8 more
wiley   +1 more source

UPLC‐QTOF‐MS/MS and Antifungal Activity of a Fraction Enriched in Saponins From Sarcomphalus joazeiro Against Candida spp

Biomedical Chromatography, Volume 40, Issue 7, July 2026.
ABSTRACT The development of antifungal resistance is a complex process that involves the interaction between hosts, drugs, and microbial factors, all of which contribute to therapeutic ineffectiveness. For this reason, studies on natural products as possible therapeutic alternatives are increasingly necessary in order to gain a better understanding of ...
Ana Raquel Pereira da Silva, Maria do Socorro Costa, Nara Juliana Santos Araújo, Gabriel Gonçalves Alencar, Talysson Felismino Moura, Victor Juno Alencar Fonseca, Antônia Thassya Lucas dos Santos, Maria Flaviana Bezerra Morais‐Braga, Erlânio Oliveira de Souza, Josean Fechine Tavares, Paulo Riceli Vasconcelos Ribeiro, Jacqueline Cosmo Andrade‐Pinheiro, Henrique Douglas Melo Coutinho   +12 more
wiley   +1 more source

Antibiofilm, Antimicrobial, and Anti‐inflammatory Potential of Rubus chamaemorus Rhizome, Leaf, and Fruit Extracts

Chemistry &Biodiversity, Volume 23, Issue 7, July 2026.
Rhizome, leaf, and fruit extracts of cloudberry (Rubus chamaemorus L., Rosaceae) are systematically evaluated for biological activities relevant to wound infections. The methanolic leaf extract exhibits potent antibiofilm and anti‐inflammatory activity without cytotoxicity, whereas rhizome and fruit extracts are largely inactive.
Hildegard Kieninger, Stefanie Koenig, Nadin Schultze, Ulrike Garscha, Sebastian Guenther, Christian Schulze   +5 more
wiley   +1 more source

Integrated Approach for the Discovery of Antifungal and Antibiofilm Agents From Cerrado Plants

Chemistry &Biodiversity, Volume 23, Issue 7, July 2026.
A comprehensive screening of 108 Brazilian Cerrado plant extracts identified potent inhibitors of Candida albicans biofilm formation. Active samples underwent UPLC–MS/MS and molecular networking for compound annotation, followed by in silico docking. This integrated workflow accelerates the discovery of bioactive metabolites by combining experimental ...
Lorena C. Albernaz, Amanda M. Almeida, Laís S. Morais, Alice M. S. Rodrigues, Rodrigo S. Ferreira, Laila S. Espindola, Marion Girardot, Christine Imbert   +7 more
wiley   +1 more source