Results 171 to 180 of about 1,624 (196)

Focus on fungi. [PDF]

Cell
Iliev ID, Brown GD, Bacher P, Gaffen SL, Heitman J, Klein BS, Lionakis MS.   +6 more
europepmc   +1 more source

"Meet the IUPAB councilor"-Thomas Gutsmann. [PDF]

Biophys Rev
Gutsmann T.
europepmc   +1 more source

<i>Candida albicans</i> and <i>Candida glabrata</i>: global priority pathogens. [PDF]

Microbiol Mol Biol Rev
Katsipoulaki M, Stappers MHT, Malavia-Jones D, Brunke S, Hube B, Gow NAR.   +5 more
europepmc   +1 more source

An approach to analyze spatiotemporal patterns of gene expression at single-cell resolution in Candida albicans-infected mouse tongues. [PDF]

mSphere
Lindemann-Perez E, Rodríguez DL, Pérez JC.   +2 more
europepmc   +1 more source

Molecular Mechanisms Underpinning the Virulence of Candida albicans [PDF]

Paulin, Olivia
core  

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Secretion of the fungal toxin candidalysin is dependent on conserved precursor peptide sequences

Nature Microbiology
The opportunistic fungal pathogen Candida albicans damages host cells via its peptide toxin, candidalysin. Before secretion, candidalysin is embedded in a precursor protein, Ece1, which consists of a signal peptide, the precursor of candidalysin and seven non-candidalysin Ece1 peptides (NCEPs), and is found to be conserved in clinical isolates. Here we
Rita Müller, Robert Zarnowski, Renata Janaína Pereira De Souza   +2 more
exaly   +6 more sources

Heparin interacts with candidalysin and neutralizes its cytotoxicity to oral epithelial cells.

Journal of Oral Biosciences, 2023
Candidalysin is a peptide toxin produced by Candida albicans that causes damage to epithelial cells by destabilizing the plasma membrane. This study aimed to evaluate heparin's ability to neutralize candidalysin and protect epithelial cells from lysis.The study was conducted using a human oral epithelial cell line and synthetic candidalysin.
Eisuke Domae, A. Kamada, Yoshihiro Yoshikawa, T. Ikeo   +3 more
semanticscholar   +3 more sources

Candidalysin, a Virulence Factor of Candida albicans, Stimulates Mast Cells by Mediating Cross-Talk Between Signaling Pathways Activated by the Dectin-1 Receptor and MAPKs

Journal of Clinical Immunology, 2022
François Niyonsaba
exaly   +2 more sources

Candidalysin: discovery and function in Candida albicans infections

Current Opinion in Microbiology, 2019
Candidalysin is a cytolytic peptide toxin secreted by the invasive form of the human pathogenic fungus, Candida albicans. Candidalysin is critical for mucosal and systemic infections and is a key driver of host cell activation, neutrophil recruitment and Type 17 immunity.
Julian R Naglik, Sarah Gaffen, Bernhard Hube   +2 more
exaly   +5 more sources

Candidalysin: An unlikely aide for fungal gut commensalism.

Cell Host & Microbe
Fungi colonize the mammalian gastrointestinal (GI) tract and can adopt both commensal and opportunistic lifestyles. In a recent issue of Nature, Liang et al. unraveled the complex interplay between Candida morphotypes and the gut bacterial microbiota and described a key role for candidalysin in gut colonization.1.
Jesús A. Romo, J. Lopez-Ribot
semanticscholar   +3 more sources