Results 181 to 190 of about 1,624 (196)
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In Vitro Biophysical Characterization of Candidalysin: A Fungal Peptide Toxin.
Methods in molecular biology, 2022In 2016, the first peptide toxin in any human fungal pathogen was identified. It was discovered in Candida albicans and was named candidalysin. Candidalysin is an amphipathic cationic peptide that damages cell membranes. Like most lytic peptides, candidalysin shows alpha-helical secondary structure.
Sejeong Lee +4 more
semanticscholar +4 more sources
International Immunopharmacology, 2023
Candidalysin is a fungal peptide toxin secreted by Candida albicans hyphae during invasion into epithelial cells. In Candida albicans-infected mucosa, candidalysin causes epithelial cell damage and activates downstream inflammatory responses, especially the release of inflammatory cytokines. However, the role of candidalysin in Candida albicans corneal
Li-ting Hu +7 more
semanticscholar +3 more sources
Candidalysin is a fungal peptide toxin secreted by Candida albicans hyphae during invasion into epithelial cells. In Candida albicans-infected mucosa, candidalysin causes epithelial cell damage and activates downstream inflammatory responses, especially the release of inflammatory cytokines. However, the role of candidalysin in Candida albicans corneal
Li-ting Hu +7 more
semanticscholar +3 more sources
Journal of Oral Biosciences, 2023
Candidalysin (CL), a hydrophobic peptide toxin secreted by Candida albicans, is a key virulence factor that contributes to cytolysis, tissue damage, and immune activation. CL is thought to exert some of its biological activities, including IL-1β production, through the activation of the NLRP3-inflammasome pathway.
Taiki Mori, H. Kataoka, T. Into
semanticscholar +3 more sources
Candidalysin (CL), a hydrophobic peptide toxin secreted by Candida albicans, is a key virulence factor that contributes to cytolysis, tissue damage, and immune activation. CL is thought to exert some of its biological activities, including IL-1β production, through the activation of the NLRP3-inflammasome pathway.
Taiki Mori, H. Kataoka, T. Into
semanticscholar +3 more sources
When platelets meet candidalysin: “We just Wnt to have fun”
Allergy. European Journal of Allergy and Clinical Immunology, 2022contributions to the field of airway mycosis and complement their previous studies on fungi- induced pathophysiology of upper respiratory infections and asthma.
O. Bulut +2 more
semanticscholar +1 more source
Detection of Cytolysis Peptide Toxin Gene (Candidalysin) in Candida albicans Isolates [PDF]
Indian Journal of Public Health Research & Development, 2019 This study was launched to identify the presence of the gene; ece1 (extent of cell elongation 1), encodes for a precursor protein related to the candidalysin, a cytolytic peptide toxin important for the induction of mucosal-related infections, in isolates of Candida albicans. Initially, 30 isolates of C.
openaire +1 more source
International Immunopharmacology
Oropharyngeal candidiasis significantly impacts patients' quality of life. Although the immune mechanisms underlying OPC have been explored, the roles of immune checkpoints and macrophages in this context remain unclear. We employed single-cell techniques to analyze changes in the oral immune microenvironment and explored the role of Tim-3 in OPC.
Siqi Liu +9 more
semanticscholar +3 more sources
Oropharyngeal candidiasis significantly impacts patients' quality of life. Although the immune mechanisms underlying OPC have been explored, the roles of immune checkpoints and macrophages in this context remain unclear. We employed single-cell techniques to analyze changes in the oral immune microenvironment and explored the role of Tim-3 in OPC.
Siqi Liu +9 more
semanticscholar +3 more sources
Journal of Microbiology
Opportunistic fungal pathogens, responsible for over 300 million severe cases and 1.5 million deaths annually, pose a serious global health threat, especially in immunocompromised individuals.
Eui-Seong Kim +6 more
semanticscholar +1 more source
Opportunistic fungal pathogens, responsible for over 300 million severe cases and 1.5 million deaths annually, pose a serious global health threat, especially in immunocompromised individuals.
Eui-Seong Kim +6 more
semanticscholar +1 more source
Epithelial targets of Candidalysin
C57BL/6 or CD1 mice were administered vehicle (3% carboxymethylcelluose in PBS) gel or gel containing 5 mg/mL dextran sodium sulfate (DSS) 1 day prior to infection. They were then challenged intravaginally with 5x10^6 C. albicans followed by vehicle or DSS 2 h later, which continued daily throughout the study.Miao, Jian, Peters, Brian
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