Results 301 to 310 of about 1,412,519 (351)
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Candidate Genes for Insulin Resistance
Diabetes Care, 1996Insulin resistance confers increased susceptibility to NIDDM, atherosclerotic cardiovascular disease, ovarian hyperandrogenism, and possibly hypertension. Insulin resistance is largely inherited, in rare cases as a monogenic disorder or more commonly as a complex trait.
D E, Moller, C, Bjørbaek, A, Vidal-Puig
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Pharmacogenetic Candidate Genes for Melanoma
Pharmacogenomics, 2003The incidence of melanoma is rising at an alarming rate and has become an important public health concern. If detected early, melanoma carries an excellent prognosis after appropriate surgical resection. Unfortunately, advanced melanoma has a poor prognosis and is notoriously resistant to radiation and chemotherapy.
Christopher, Hull +2 more
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Candidate Gene Association Analysis
2009Candidate gene association study is the most common method for associating human genetic variations with the phenotypes they produce, due to the relative simplicity of acquiring patient samples and genotype data. The study design begins with identifying appropriate DNA samples and an appropriate phenotype for analysis.
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Polymorphisms in Candidate Asthma Genes
The American Journal of the Medical Sciences, 2001The triad of reversible airway obstruction, bronchial hyperresponsiveness, and airway inflammation characterizes asthma. The etiology of asthma is complex and involves the interaction of multiple genetic foci and a variety of environmental factors, such as protein allergens, chemical sensitizers, and viral or bacterial proteins.
U, Nanavaty, A D, Goldstein, S J, Levine
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Candidate genes for behavioural ecology
Trends in Ecology & Evolution, 2005In spite of millions of years of evolutionary divergence, the conservation of gene function is common across distant lineages. As such, genes that are known to influence behaviour in one organism are likely to influence similar behaviours in other organisms.
Fitzpatrick, M.J. +5 more
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Candidate Gene Association Studies
2010Candidate gene association studies aim to establish or characterise association between the genetic -variation occurring within a specific gene or locus and a phenotype. If the phenotype is quantitative, then the effect size is often measured as the difference between the genotype specific means or a per allele effect.
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Candidate Genes in Eating Disorders
Current Drug Target -CNS & Neurological Disorders, 2003Environmental influences, as well as biological and genetic factors influence risk for eating disorders. Family and twin studies have shown that eating disorders are familial and suggest the influence of genetic factors on their etiology. Positive associations have been observed for some candidate genes that have been studied (such as 5HT2A receptor ...
Federica, Tozzi, Cynthia M, Bulik
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Candidate gene case-control studies
Pharmacogenomics, 2003Two main approaches to the identification of genes are involved in polygenic diseases. Use of family studies has generally been the preferred approach up until recently, but this is only feasible if the genetic component of the disease is relatively strong and DNA samples are available from other family members.
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Candidate gene prioritization.
Molecular genetics and genomics : MGG, 2012Candidate gene identification is typically labour intensive, involving laboratory experiments required to corroborate or disprove any hypothesis for a nominated candidate gene being considered the causative gene. The traditional approach to reduce the number of candidate genes entails fine-mapping studies using markers and pedigrees.
Ali, Masoudi-Nejad +3 more
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