Results 41 to 50 of about 1,567,650 (332)

Candidate and non-candidate genes in behavior genetics

open access: yesCurrent Opinion in Neurobiology, 2013
In this review we discuss recent developments in psychiatric genetics: on the one hand, studies using whole genome approaches (genome-wide association studies (GWAS) and exome sequencing) are coming close to finding genes and molecular variants that contribute to disease susceptibility; on the other candidate genes, such as the serotonin transporter ...
Flint, Jonathan, Munafò, Marcus R
openaire   +5 more sources

Rab14 regulates the transport of human papillomavirus to the trans‐Golgi network for infectious cell entry

open access: yesFEBS Letters, EarlyView.
This study reveals that the small GTPase Rab14 is necessary for human papillomavirus (HPV) infection and plays an essential role in the transport of virions to the trans‐Golgi network (TGN). HPV in the early endosome (EE), which harbors GTP‐bound Rab14, is transported to the TGN through the switch of Rab14 from its GTP‐bound to GDP‐bound form.
Yoshiyuki Ishii, Iwao Kukimoto
wiley   +1 more source

Theorising Europeanisation in European Literature: Conceptualisation and Operationalisation

open access: yesAustralian and New Zealand Journal of European Studies, 2021
There has been an extensive academic debate on the impact of the European Union on its member states, on the candidate countries for EU membership and the countries in its geographical neighbourhood.
Daviti Mtchedlishvili
doaj   +1 more source

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

open access: yesFEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

open access: yesFEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa   +2 more
wiley   +1 more source

Personalized politics in turbulent times: patterns of decentralized personalization in the 2022 Italian general elections

open access: yesItalian Political Science, 2023
One of the most significant phenomena in contemporary politics is personalization. Several studies have shown that voters are more influenced by the characteristics of leaders and/or candidates than in the past.
Matteo Boldrini
doaj  

Elections to the Highest State Authorities in Western Belarus in 1940 as an Element of the Region’ Sovietization

open access: yesВестник Волгоградского государственного университета. Серия 4. История, регионоведение, международные отношения, 2017
The article deals with one of the poorly studied fragments of Russian history – elections of deputies of the USSR Supreme Council and the BSSR Supreme Council for Western Belarus.
Aleksandr V. Kuryanovich
doaj   +1 more source

Design and analysis strategies for robust microbiome ageing research

open access: yesFEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik   +5 more
wiley   +1 more source

Campaign individualization in a comparative perspective: does the context matter?

open access: yesRevista da Faculdade de Letras. Série de História, 2019
Despite a great flourishing of studies on election campaigns, the issue of individualized campaigns has been widely neglected, especially from a comparative perspective. Yet, campaigns differ not only in terms of strategy or style, but also with regard
Marco Lisi, José Santana Pereira
doaj   +1 more source

ABL kinase‐dependent phosphorylation of SH proteins promotes their direct interaction with CRK family SH2 domains

open access: yesFEBS Letters, EarlyView.
CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens   +8 more
wiley   +1 more source

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